Emergence and genomic characterization of the first reported optrA-carrying linezolid-resistant enterococci isolated from retail broiler meat in the United Arab Emirates

The foodborne transfer of resistant genes from enterococci to humans and their tolerance to several commonly used antimicrobials are of growing concern worldwide. Linezolid is a last-line drug for managing complicated illnesses resulting from multidrug-resistant Gram-positive bacteria. The optrA gene has been reported in enterococci as one of the acquired linezolid resistance mechanisms. The present study uses whole-genome sequencing analysis to characterize the first reported isolates of linezolid-resistant E. faecium (n = 6) and E. faecalis (n = 10) harboring the optrA gene isolated from samples of supermarket broiler meat (n = 165) in the United Arab Emirates (UAE). The sequenced genomes were used to appraise the study isolates’ genetic relatedness, antimicrobial resistance determinants, and virulence traits. All 16 isolates carrying the optrA gene demonstrated multidrug-resistance profiles. Genome-based relatedness classified the isolates into five clusters that were independent of the isolate sources. The most frequently known genotype among the isolates was the sequence type ST476 among E. faecalis (50% (5/10)). The study isolates revealed five novel sequence types. Antimicrobial resistance genes (ranging from 5 to 13) were found among all isolates that conferred resistance against 6 to 11 different classes of antimicrobials. Sixteen different virulence genes were found distributed across the optrA-carrying E. faecalis isolates. The virulence genes in E. faecalis included genes encoding invasion, cell adhesion, sex pheromones, aggregation, toxins production, the formation of biofilms, immunity, antiphagocytic activity, proteases, and the production of cytolysin. This study presented the first description and in-depth genomic characterization of the optrA-gene-carrying linezolid-resistant enterococci from retail broiler meat in the UAE and the Middle East. Our results call for further monitoring of the emergence of linezolid resistance at the retail and farm levels. These findings elaborate on the importance of adopting a One Health surveillance approach involving enterococci as a prospective bacterial indicator for antimicrobial resistance spread at the human–food interface

Hagedorn Strings and Correspondence Principle in AdS(3)

Motivated by the possibility of formulating a strings/black hole correspondence in AdS space, we extract the Hagedorn behavior of thermal AdS_3 bosonic string from 1-loop partition function of SL(2,R) WZW model. We find that the Hagedorn temperature is monotonically increasing as the AdS radius shrinks, reaches a maximum of order of string scale set by the unitarity bound of the CFT for internal space. The resulting density of states near the Hagedorn temperature resembles the form as for strings in flat space and is dominated by the space-like long string configurations. We then argue a conjectured strings/black hole correspondence in AdS space by applying the Hagedorn thermodynamics. We find the size of the corresponding black hole is a function of the AdS radius. For large AdS radius a black hole far bigger than the string scale will form. On the contrary, when the AdS and string scales are comparable a string size black hole will form. We also examine strings on BTZ background obtained through SL(2,Z) transformation. We find a tachyonic divergence for a BTZ black hole of string scale size.Comment: 28 pages, 4 figures;v2 references added & appear on JHE

Study of color connections in e+e−e^+ e^- annihilation

We replace in the event generator JETSET the color singlet chain connection with the color separate state one as the interface between the hard and soft sectors of hadronic processes. The modified generator is applied to produce the hadronic events in $e^+ e^-$ annihilation. It describes the experimental data at the same level as the original JETSET with default parameters. This should be understood as a demonstration that color singlet chain is not the unique color connection. We also search for the difference in special sets of three-jet events arising from different color connections, which could subject to further experimental test.Comment: 23 pages, 8 figures, 4 tables, Revtex

On Vanishing Theorems For Vector Bundle Valued p-Forms And Their Applications

Let $F: [0, \infty) \to [0, \infty)$ be a strictly increasing $C^2$ function with $F(0)=0$. We unify the concepts of $F$-harmonic maps, minimal hypersurfaces, maximal spacelike hypersurfaces, and Yang-Mills Fields, and introduce $F$-Yang-Mills fields, $F$-degree, $F$-lower degree, and generalized Yang-Mills-Born-Infeld fields (with the plus sign or with the minus sign) on manifolds. When $F(t)=t, \frac 1p(2t)^{\frac p2}, \sqrt{1+2t} -1,$ and $1-\sqrt{1-2t},$ the $F$-Yang-Mills field becomes an ordinary Yang-Mills field, $p$-Yang-Mills field, a generalized Yang-Mills-Born-Infeld field with the plus sign, and a generalized Yang-Mills-Born-Infeld field with the minus sign on a manifold respectively. We also introduce the $E_{F,g}-$energy functional (resp. $F$-Yang-Mills functional) and derive the first variational formula of the $E_{F,g}-$energy functional (resp. $F$-Yang-Mills functional) with applications. In a more general frame, we use a unified method to study the stress-energy tensors that arise from calculating the rate of change of various functionals when the metric of the domain or base manifold is changed. These stress-energy tensors, linked to $F$-conservation laws yield monotonicity formulae. A "macroscopic" version of these monotonicity inequalities enables us to derive some Liouville type results and vanishing theorems for $p-$forms with values in vector bundles, and to investigate constant Dirichlet boundary value problems for 1-forms. In particular, we obtain Liouville theorems for $F-$harmonic maps (e.g. $p$-harmonic maps), and $F-$Yang-Mills fields (e.g. generalized Yang-Mills-Born-Infeld fields on manifolds). We also obtain generalized Chern type results for constant mean curvature type equations for $p-$forms on $\Bbb{R}^m$ and on manifolds $M$ with the global doubling property by a different approach. The case $p=0$ and $M=\mathbb{R}^m$ is due to Chern.Comment: 1. This is a revised version with several new sections and an appendix that will appear in Communications in Mathematical Physics. 2. A "microscopic" approach to some of these monotonicity formulae leads to celebrated blow-up techniques and regularity theory in geometric measure theory. 3. Our unique solution of the Dirichlet problems generalizes the work of Karcher and Wood on harmonic map

Filtering out the cosmological constant in the Palatini formalism of modified gravity

According to theoretical physics the cosmological constant (CC) is expected to be much larger in magnitude than other energy densities in the universe, which is in stark contrast to the observed Big Bang evolution. We address this old CC problem not by introducing an extremely fine-tuned counterterm, but in the context of modified gravity in the Palatini formalism. In our model the large CC term is filtered out, and it does not prevent a standard cosmological evolution. We discuss the filter effect in the epochs of radiation and matter domination as well as in the asymptotic de Sitter future. The final expansion rate can be much lower than inferred from the large CC without using a fine-tuned counterterm. Finally, we show that the CC filter works also in the Kottler (Schwarzschild-de Sitter) metric describing a black hole environment with a CC compatible to the future de Sitter cosmos.Comment: 22 pages, 1 figure, discussion extended, references added, accepted by Gen.Rel.Gra

The Ricci flow on noncommutative two-tori

In this paper we construct a version of Ricci flow for noncommutative 2-tori, based on a spectral formulation in terms of the eigenvalues and eigenfunction of the Laplacian and recent results on the Gauss-Bonnet theorem for noncommutative tori.Comment: 18 pages, LaTe

The open-charm radiative and pionic decays of molecular charmonium Y(4274)

In this work, we investigate the decay widths and the line shapes of the open-charm radiative and pionic decays of Y(4274) with the $D_s\bar{D}_{s0}(2317)$ molecular charmonium assignment. Our calculation indicates that the decay widths of $Y(4274)\to D^{+}_{s}D^{*-}_{s}\gamma$ and $Y(4274)\to D^+_{s}D^-_{s}\pi^0$ can reach up to 0.05 keV and 0.75 keV, respectively. In addition, the result of the line shape of the photon spectrum of $Y(4274)\to D_s^+ {D}_s^{*-} \gamma$ shows that there exists a very sharp peak near the large end point of photon energy. The line shape of the pion spectrum of $Y(4274)\to D_s^+ {D}_s^{*-} \pi^0$ is similar to that of the pion spectrum of $Y(4274)\to D_s^+ {D}_s^{*-} \gamma$, where we also find a very sharp peak near the large end point of pion energy. According to our calculation, we suggest further experiments to carry out the search for the open-charm radiative and pionic decays of Y(4274).Comment: 7 pages, 6 figures, 1 table. Published versio

Precise measurement of hadronic tau-decays with an eta meson

We have studied hadronic tau decay modes involving an eta meson using 490 fb^{-1} of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. The following branching fractions have been measured: B(tau- -> K- eta nu)=(1.58 +- 0.05 +- 0.09)x 10^{-4}, B(tau- -> K- pi0 eta nu)=(4.6 +- 1.1 +- 0.4)x 10^{-5}, B(tau- -> pi- pi0 eta nu)=(1.35 +- 0.03 +- 0.07)x 10^{-3}, B(tau- -> pi- KS eta nu)=(4.4 +- 0.7 +- 0.2)x 10^{-5}, and B(tau- -> K^{*-} eta nu)=(1.34 +- 0.12 +- 0.09)x 10^{-4}. These results are substantially more precise than previous measurements. The new measurements are compared with theoretical calculations based on the CVC hypothesis or the chiral perturbation theory. We also set upper limits on branching fractions for tau decays into K- KS eta nu, pi- KS pi0 eta nu, K- eta eta nu, pi- eta eta nu and non-resonant K- pi^0 eta nu final states.Comment: 24 pages, 7 figure

Observation of the ϕ(1680)\phi(1680) and the Y(2175) in e+e−→ϕπ+π−e^+ e^- \to \phi\pi^+\pi^-

The cross sections for $e^+ e^- \to \phi\pi^+\pi^-$ and e^+ e^- \to \phi \fzero are measured from threshold to $\sqrt{s}=3.0$ $\hbox{GeV}$ using initial state radiation. The analysis is based on a data sample of 673 fb$^{-1}$ collected on and below the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. First measurements are reported for the resonance parameters of the $\phi(1680)$ in the $\phi\pi^+\pi^-$ mode: $m=(1689\pm 7\pm 10)$ MeV/$c^2$ and $\Gamma=(211\pm 14\pm 19)$ MeV/$c^2$. A structure at $\sqrt{s}=2.1 \hbox{GeV}/c^2$, corresponding to the so called Y(2175), is observed; its mass and width are determined to be $2079\pm13^{+79}_{-28}$ MeV/$c^2$ and $192\pm23^{+25}_{-61} \hbox{MeV}/c^2$, respectively.Comment: 11 pages, 6 figures. Add one plot. Accepted by Phys.Rev.D(RC

Anthropogenic Space Weather

Anthropogenic effects on the space environment started in the late 19th century and reached their peak in the 1960s when high-altitude nuclear explosions were carried out by the USA and the Soviet Union. These explosions created artificial radiation belts near Earth that resulted in major damages to several satellites. Another, unexpected impact of the high-altitude nuclear tests was the electromagnetic pulse (EMP) that can have devastating effects over a large geographic area (as large as the continental United States). Other anthropogenic impacts on the space environment include chemical release ex- periments, high-frequency wave heating of the ionosphere and the interaction of VLF waves with the radiation belts. This paper reviews the fundamental physical process behind these phenomena and discusses the observations of their impacts.Comment: 71 pages, 35 figure