Topology Change of Coalescing Black Holes on Eguchi-Hanson Space

We construct multi-black hole solutions in the five-dimensional Einstein-Maxwell theory with a positive cosmological constant on the Eguchi-Hanson space, which is an asymptotically locally Euclidean space. The solutions describe the physical process such that two black holes with the topology of S^3 coalesce into a single black hole with the topology of the lens space L(2;1)=S^3/Z_2. We discuss how the area of the single black hole after the coalescence depends on the topology of the horizon.Comment: 10 pages, Some comments are added. to be published as a letter in Classical and Quantum Gravit

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

Journal ArticleCopyright © The Author(s) 2015. This article is published with open access at Springerlink.com.Aims/hypothesis: Intronic single nucleotide polymorphisms (SNPs) in the CDKAL1 gene are associated with risk of developing type 2 diabetes. A strong correlation between risk alleles and lower levels of the non-coding RNA, CDKAL1-v1, has recently been reported in whole blood extracted from Japanese individuals. We sought to replicate this association in two independent cohorts: one using whole blood from white UK-resident individuals, and one using a collection of human pancreatic islets, a more relevant tissue type to study with respect to the aetiology of diabetes. Methods: Levels of CDKAL1-v1 were measured by real-time PCR using RNA extracted from human whole blood (n = 70) and human pancreatic islets (n = 48). Expression with respect to genotype was then determined. Results: In a simple linear regression model, expression of CDKAL1-v1 was associated with the lead type 2 diabetes-associated SNP, rs7756992, in whole blood and islets. However, these associations were abolished or substantially reduced in multiple regression models taking into account rs9366357 genotype: a moderately linked SNP explaining a much larger amount of the variation in CDKAL1-v1 levels, but not strongly associated with risk of type 2 diabetes. Conclusions/interpretation: Contrary to previous findings, we provide evidence against a role for dysregulated expression of CDKAL1-v1 in mediating the association between intronic SNPs in CDKAL1 and susceptibility to type 2 diabetes. The results of this study illustrate how caution should be exercised when inferring causality from an association between disease-risk genotype and non-coding RNA expression.MRCNIH

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

This is the final version of the article. Available from Springer Verlag via the DOI in this record.AIMS/HYPOTHESIS: Intronic single nucleotide polymorphisms (SNPs) in the CDKAL1 gene are associated with risk of developing type 2 diabetes. A strong correlation between risk alleles and lower levels of the non-coding RNA, CDKAL1-v1, has recently been reported in whole blood extracted from Japanese individuals. We sought to replicate this association in two independent cohorts: one using whole blood from white UK-resident individuals, and one using a collection of human pancreatic islets, a more relevant tissue type to study with respect to the aetiology of diabetes. METHODS: Levels of CDKAL1-v1 were measured by real-time PCR using RNA extracted from human whole blood (n = 70) and human pancreatic islets (n = 48). Expression with respect to genotype was then determined. RESULTS: In a simple linear regression model, expression of CDKAL1-v1 was associated with the lead type 2 diabetes-associated SNP, rs7756992, in whole blood and islets. However, these associations were abolished or substantially reduced in multiple regression models taking into account rs9366357 genotype: a moderately linked SNP explaining a much larger amount of the variation in CDKAL1-v1 levels, but not strongly associated with risk of type 2 diabetes. CONCLUSIONS/INTERPRETATION: Contrary to previous findings, we provide evidence against a role for dysregulated expression of CDKAL1-v1 in mediating the association between intronic SNPs in CDKAL1 and susceptibility to type 2 diabetes. The results of this study illustrate how caution should be exercised when inferring causality from an association between disease-risk genotype and non-coding RNA expression.This paper presents independent research funded by the Medical Research Council (grant number MR/J006777/1) and supported by the National Institute for Health Research (NIHR) Exeter Clinical Research Facility. The views expressed are those of the authors and not necessarily those of the Medical Research Council, UK National Health Service, NIHR or the UK Department of Health

Uniqueness Theorem for Black Hole Space-Times with Multiple Disconnected Horizons

We show uniqueness of stationary and asymptotically flat black hole space-times with multiple disconnected horizons and with two rotational Killing vector fields in the context of five-dimensional minimal supergravity (Einstein-Maxwell-Chern-Simons gravity). The novelty in this work is the introduction in the uniqueness theorem of intrinsic local charges measured near each horizon as well as the measurement of local fluxes besides the asymptotic charges that characterize a particular solution. A systematic method of defining the boundary conditions on the fields that specify a black hole space-time is given based on the study of its rod structure (domain structure). Also, an analysis of known solutions with disconnected horizons is carried out as an example of an application of this theorem.Comment: 28 pages, 5 figures. v3: Further improvements on uniqueness theorem, Lemma introduced for clarity of derivation, new quantities introduced to treat special case with zero flux, refs. added, typos fixe

Charged Black Holes in a Rotating Gross-Perry-Sorkin Monopole Background

We present a new class of stationary charged black hole solutions to five-dimensional Einstein-Maxwell-Chern-Simons theories. We construct the solutions by utilizing so called the squashing transformation. At infinity, our solutions behave as a four-dimensional flat spacetime plus a `circle' and hence describe a Kaluza-Klein black hole. More precisely, our solutions can be viewed as a charged rotating black hole in a rotating Gross-Perry-Sorkin monopole background with the black hole rotation induced from the background rotation.Comment: 25 pages, 6 figure

Spin diffusion/transport in nn-type GaAs quantum wells

The spin diffusion/transport in $n$-type (001) GaAs quantum well at high temperatures ($\ge120$ K) is studied by setting up and numerically solving the kinetic spin Bloch equations together with the Poisson equation self-consistently. All the scattering, especially the electron-electron Coulomb scattering, is explicitly included and solved in the theory. This enables us to study the system far away from the equilibrium, such as the hot-electron effect induced by the external electric field parallel to the quantum well. We find that the spin polarization/coherence oscillates along the transport direction even when there is no external magnetic field. We show that when the scattering is strong enough, electron spins with different momentums oscillate in the same phase which leads to equal transversal spin injection length and ensemble transversal injection length. It is also shown that the intrinsic scattering is already strong enough for such a phenomena. The oscillation period is almost independent on the external electric field which is in agreement with the latest experiment in bulk system at very low temperature [Europhys. Lett. {\bf 75}, 597 (2006)]. The spin relaxation/dephasing along the diffusion/transport can be well understood by the inhomogeneous broadening, which is caused by the momentum-dependent diffusion and the spin-orbit coupling, and the scattering. The scattering, temperature, quantum well width and external magnetic/electric field dependence of the spin diffusion is studied in detail.Comment: 12 pages, 6 figures, to be published in J Appl. Phy

Charged black rings in supergravity with a single non-zero gauge field

General charged black ring solution with two angular momenta, a charge and a dipole charge is found by the inverse scattering method. The solution is presented in a relatively concise form in which its symmetries are manifest. The regularity conditions are found and the physical characteristics of the regular solution are expressed via its parameters.Comment: Misprints corrected, references added, JHEP forma

Opposite field septum magnet system for the separation of charged particle beams

Abstract-The Japan Hadron Facility (JHF) accelerator complex comprises a 50-GeV main synchrotron, a 3-GeV rapid-cycling synchrotron, and a 400-MeV linac. The accelerators provide high-intensity, high-energy proton beams for various scientific fields. These high-intensity, high-energy accelerators, especially the 50-GeV main synchrotron, impose tight demands on the injection/extraction septum magnets for a thin structure, large aperture and high operating field. But to manufacture high field septum magnets on the condition of a large aperture is very difficult because of its extraordinarily strong electromagnetic force due to the self-field. To cope with these tight demands, new design concepts of septa are required. An opposite-field septum magnet system is one of the solutions to realize a thin septa or very high-field septum magnets

G2 Dualities in D=5 Supergravity and Black Strings

Five dimensional minimal supergravity dimensionally reduced on two commuting Killing directions gives rise to a G2 coset model. The symmetry group of the coset model can be used to generate new solutions by applying group transformations on a seed solution. We show that on a general solution the generators belonging to the Cartan and nilpotent subalgebras of G2 act as scaling and gauge transformations, respectively. The remaining generators of G2 form a sl(2,R)+sl(2,R) subalgebra that can be used to generate non-trivial charges. We use these generators to generalize the five dimensional Kerr string in a number of ways. In particular, we construct the spinning electric and spinning magnetic black strings of five dimensional minimal supergravity. We analyze physical properties of these black strings and study their thermodynamics. We also explore their relation to black rings.Comment: typos corrected (26 pages + appendices, 2 figures