Coded Modulation for Satellite Broadcasting

In this paper, three-level block coded 8-PSK modulations, suitable for satellite broadcasting of digital TV signals, are presented. A design principle to achieve unequal error protection is introduced. The coding scheme is designed in such a way that the information bits carrying the basic definition TV signal have a lower error rate than the high definition information bits. The large error coefficients, formally associated with standard mapping by set partitioning, are reduced by considering a nonstandard partition of an 8-PSK signal set. The bits-to-signal mapping induced by this partition allows the use of suboptimal low-complexity soft-decision decoding of binary block codes. Parallel operation of the first and second stage decoders is possible, for high data rate transmission. Furthermore, there is no error propagation from the first-stage decoder to the second-stage decoder

MicroRNA-23a promotes myelination in the central nervous system.

Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-23a-overexpressing mice have increased myelin thickness, providing in vivo evidence that miR-23a enhances both oligodendrocyte differentiation and myelin synthesis. Using this mouse model, we explored possible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kinase/Akt/mammalian target of rapamycin pathway is modulated by miR-23a. Additionally, a long noncoding RNA, 2700046G09Rik, was identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner. The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin

S-Lemma with Equality and Its Applications

Let $f(x)=x^TAx+2a^Tx+c$ and $h(x)=x^TBx+2b^Tx+d$ be two quadratic functions having symmetric matrices $A$ and $B$. The S-lemma with equality asks when the unsolvability of the system $f(x)<0, h(x)=0$ implies the existence of a real number $\mu$ such that $f(x) + \mu h(x)\ge0, ~\forall x\in \mathbb{R}^n$. The problem is much harder than the inequality version which asserts that, under Slater condition, $f(x)<0, h(x)\le0$ is unsolvable if and only if $f(x) + \mu h(x)\ge0, ~\forall x\in \mathbb{R}^n$ for some $\mu\ge0$. In this paper, we show that the S-lemma with equality does not hold only when the matrix $A$ has exactly one negative eigenvalue and $h(x)$ is a non-constant linear function ($B=0, b\not=0$). As an application, we can globally solve $\inf\{f(x)\vert h(x)=0\}$ as well as the two-sided generalized trust region subproblem $\inf\{f(x)\vert l\le h(x)\le u\}$ without any condition. Moreover, the convexity of the joint numerical range $\{(f(x), h_1(x),\ldots, h_p(x)):~x\in\Bbb R^n\}$ where $f$ is a (possibly non-convex) quadratic function and $h_1(x),\ldots,h_p(x)$ are affine functions can be characterized using the newly developed S-lemma with equality.Comment: 34 page

A New Recursive Dynamic Lot-Sizing Model with Multi-Level Discount

The optimal solution of dynamic lot-sizing problem with multi-level discount is solved by integer programming model in the past papers. However, a complex computation and a large computer memory are generated. Due to the complexity and the big computer memory, the heuristic approaches and the variable neighborhood algorithm are usually adopted in the large-scale multi-level lot-sizing problem. This paper develops a model with a recursive relation between the adjacent periods, and to obtain an optimal solution when multi-level discount is considered. Four types of the feasible policies in the Dynamic Lot-Sizing model with multi-level discount are classified to develop the recursive relations. A few properties, theorems and algorithms are developed to show the recursion between the adjacent periods. The number of addition items will significantly be reduced. The recursive algorithm can significantly decrease the computational entries, comparison entries and computer memory and improve the computation efficiency

Numerical analysis of integrated forming process of diagonal rolling and piercing of flange nuts

In this paper, Simufact FE software is used to establish a simulation model of three-roll diagonal roll piercing integrated forming flange nut blanks, elaborate its process principle, analyze its forming process through numerical simulation. The law of load change, equivalent plastic strain distribution and wall thickness uniformity during the piercing process and diameter reduction process were investigated, and verify the feasibility of this forming process for manufacturing flange nut blanks

Numerical analysis of integrated forming process of diagonal rolling and piercing of flange nuts

In this paper, Simufact FE software is used to establish a simulation model of three-roll diagonal roll piercing integrated forming flange nut blanks, elaborate its process principle, analyze its forming process through numerical simulation. The law of load change, equivalent plastic strain distribution and wall thickness uniformity during the piercing process and diameter reduction process were investigated, and verify the feasibility of this forming process for manufacturing flange nut blanks

Improving successful rate of transcranial electrical motor-evoked potentials monitoring during spinal surgery in young children

Introduction This prospective study was to investigate the successful rate of intraoperative motor evoked potentials (MEP) monitoring for children (0.05). As well, no difference in MEP successful rates was observed in two groups with different anesthetic techniques. No wake-up test and no post-operative neurological deficits occurred in this series of patients. Conclusion Low dose anesthesia by either TIVA with propofol or sevoflurane-based mixture anesthesia protocol can help the intraoperative spinal cord monitoring to successfully elicit MEP and perform reliable monitoring for patients below 12 years of age. © 2011 Springer-Verlag.published_or_final_versio

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy.

Protein synthesis is highly regulated throughout nervous system development, plasticity and regeneration. However, tracking the distributions of specific new protein species has not been possible in living neurons or at the ultrastructural level. Previously we created TimeSTAMP epitope tags, drug-controlled tags for immunohistochemical detection of specific new proteins synthesized at defined times. Here we extend TimeSTAMP to label new protein copies by fluorescence or photo-oxidation. Live microscopy of a fluorescent TimeSTAMP tag reveals that copies of the synaptic protein PSD95 are synthesized in response to local activation of growth factor and neurotransmitter receptors, and preferentially localize to stimulated synapses in rat neurons. Electron microscopy of a photo-oxidizing TimeSTAMP tag reveals new PSD95 at developing dendritic structures of immature neurons and at synapses in differentiated neurons. These results demonstrate the versatility of the TimeSTAMP approach for visualizing newly synthesized proteins in neurons

EXTENSIBLE DATABASE FRAMEWORK FOR MANAGEMENT OF UNSTRUCTURED AND SEMI-STRUCTURED DOCUMENTS

Method and system for querying a collection of Unstructured or semi-structured documents to identify presence of, and provide context and/or content for, keywords and/or keyphrases. The documents are analyzed and assigned a node structure, including an ordered sequence of mutually exclusive node segments or strings. Each node has an associated set of at least four, five or six attributes with node information and can represent a format marker or text, with the last node in any node segment usually being a text node. A keyword (or keyphrase) is specified. and the last node in each node segment is searched for a match with the keyword. When a match is found at a query node, or at a node determined with reference to a query node, the system displays the context andor the content of the query node