66 research outputs found
Spin- and angle-resolved photoemission studies of the electronic structure of Si(110)"16x2" surfaces
The electronic structure of Si(110)"16 x 2" double-domain, single-domain and
1 x 1 surfaces have been investigated using spin- and angle-resolved
photoemission at sample temperatures of 77 K and 300 K. Angle-resolved
photoemission was conducted using horizontally- and vertically-polarised 60 eV
and 80 eV photons. Band-dispersion maps revealed four surface states ( to
) which were assigned to silicon dangling bonds on the basis of measured
binding energies and photoemission intensity changes between horizontal and
vertical light polarisations. Three surface states (, and ),
observed in the Si(110)"16 x 2" reconstruction, were assigned to Si adatoms and
Si atoms present at the edges of the corrugated terrace structure. Only one of
the four surface states, , was observed in both the Si(110)"16 x 2" and 1
x 1 band maps and consequently attributed to the pervasive Si zigzag chains
that are components of both the Si(110)"16 x 2" and 1 x 1 surfaces. A state in
the bulk-band region was attributed to an in-plane bond. All data were
consistent with the adatom-buckling model of the Si(110)"16 x 2" surface.
Whilst room temperature measurements of and were statistically
compatible with zero, measurements of the enantiomorphic A-type and
B-type Si(110)"16 x 2" surfaces gave small average polarisations of around
1.5\% that were opposite in sign. Further measurements at 77 K on A-type
Si(110)"16 x 2" surface gave a smaller value of +0.3\%. An upper limit of
may thus be taken for the longitudinal polarisation.Comment: Main paper: 12 pages and 11 figures. Supplemental information: 5
pages and 2 figure
Antiferroquadrupolar Order in the Magnetic Semiconductor TmTe
The physical properties of the antiferroquadrupolar state occurring in TmTe
below TQ=1.8 K have been studied using neutron diffraction in applied magnetic
fields. A field-induced antiferromagnetic component k = (1/2,1/2,1/2) is
observed and, from its magnitude and direction for different orientations of H,
an O(2,2) quadrupole order parameter is inferred. Measurements below TN ~= 0.5
K reveal that the magnetic structure is canted, in agreement with theoretical
predictions for in-plane antiferromagnetism. Complex domain repopulation
effects occur when the field is increased in the ordered phases, with
discontinuities in the superstructure peak intensities above 4 T.Comment: 6 pages, 6 figures, Presented at the International Conference on
Strongly Correlated Electrons with Orbital Degrees of Freedom (ORBITAL 2001),
September 11-14, 2001 (Sendai, JAPAN). To appear in: Journal of the Physical
Society of Japan (2002
Spin Motion in Electron Transmission through Ultrathin Ferromagnetic Films Accessed by Photoelectron Spectroscopy
Ab initio and model calculations demonstrate that the spin motion of
electrons transmitted through ferromagnetic films can be analyzed in detail by
means of angle- and spin-resolved core-level photoelectron spectroscopy. The
spin motion appears as precession of the photoelectron spin polarization around
and as relaxation towards the magnetization direction. In a systematic study
for ultrathin Fe films on Pd(001) we elucidate its dependence on the Fe film
thickness and on the Fe electronic structure. In addition to elastic and
inelastic scattering, the effect of band gaps on the spin motion is addressed
in particular.Comment: 4 pages, 5 figure
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukaemia
Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i) GDC-0575 enhances AraC-mediated killing of AML cells both in vitro and in vivo, thus abrogating any potential chemoresistance mechanisms involving DNA repair. Importantly, this combination of drugs does not affect normal long-term hematopoietic stem/progenitors. Moreover, the addition of CHK1i to AraC does not generate de novo mutations and in patients' samples where AraC is mutagenic, addition of CHK1i appears to eliminate the generation of mutant clones. Finally, we observe that persistent residual leukemic cells are quiescent and can become responsive to the treatment when forced into cycle via granulocyte colony-stimulating factor (G-CSF) administration. This drug combination (AraC+CHK1i+G-CSF) will open the doors for a more efficient treatment of AML in the clinic
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the niche, and how it exerts cell-extrinsic control over myeloma cell dormancy and reactivation. In this study, we track individual myeloma cells by intravital imaging as they colonize the endosteal niche, enter a dormant state and subsequently become activated to form colonies. We demonstrate that dormancy is a reversible state that is switched ‘on’ by engagement with bone-lining cells or osteoblasts, and switched ‘off’ by osteoclasts remodelling the endosteal niche. Dormant myeloma cells are resistant to chemotherapy that targets dividing cells. The demonstration that the endosteal niche is pivotal in controlling myeloma cell dormancy highlights the potential for targeting cell-extrinsic mechanisms to overcome cell-intrinsic drug resistance and prevent disease relapse
Real-time near-field imaging of photoinduced matter motion in thin solid films containing azobenzene derivatives
International audienc
Injection energy dependence of spin-polarized hot-electron transport through a ferromagnetic metal / oxide / semiconductor junction
International audienc
Injection energy dependence of spin-polarized hot-electron transport through a ferromagnetic metal / oxide / semiconductor junction
International audienc
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