Simulation of neutrino and charged particle production and propagation in the atmosphere

A precise evaluation of the secondary particle production and propagation in the atmosphere is very important for the atmospheric neutrino oscillation studies. The issue is addressed with the extension of a previously developed full 3-Dimensional Monte-Carlo simulation of particle generation and transport in the atmosphere, to compute the flux of secondary protons, muons and neutrinos. Recent balloon borne experiments have performed a set of accurate flux measurements for different particle species at different altitudes in the atmosphere, which can be used to test the calculations for the atmospheric neutrino production, and constrain the underlying hadronic models. The simulation results are reported and compared with the latest flux measurements. It is shown that the level of precision reached by these experiments could be used to constrain the nuclear models used in the simulation. The implication of these results for the atmospheric neutrino flux calculation are discussed.Comment: 11 pages, 9 figure

Heavy--light mesons in a bilocal effective theory

Heavy--light mesons are described in an effective quark theory with a two--body vector--type interaction. The bilocal interaction is taken to be instantaneous in the rest frame of the bound state, but formulated covariantly through the use of a boost vector. The chiral symmetry of the light flavor is broken spontaneously at mean field level. The framework for our discussion of bound states is the effective bilocal meson action obtained by bosonization of the quark theory. Mesons are described by 3--dimensional wave functions satisfying Salpeter equations, which exhibit both Goldstone solutions in the chiral limit and heavy--quark symmetry for $m_Q\rightarrow\infty$. We present numerical solutions for pseudoscalar $D$-- and $B$--mesons. Heavy--light meson spectra and decay constants are seen to be sensitive to the description of chiral symmetry breaking (dynamically generated vs.\ constant quark mass).Comment: (34 p., standard LaTeX, 7 PostScript figures appended) UNITUE-THEP-17/9

Two photon decay of π0\pi^0 and η\eta at finite temperature and density

A comparative study of the anomalous decays $\pi^0, \eta \to\gamma\gamma$, at finite temperature and at finite density, is performed in the framework of the three--flavor Nambu--Jona-Lasinio. The similarities and differences between both scenarios are discussed. In both cases the lifetimes of these mesons decrease significantly at the critical point, although this might not be sufficient to observe enhancement of these decays in heavy-ion collisions.Comment: 5 pages, 1 figure. Talk given at Strange Quark Matter 2004, Cape Town, South Africa, 15-20 September, 200

f [N pi N]: from quarks to the pion derivative coupling

We study the N pi N coupling, in the framework of a QCD-inspired confining Nambu-Jona-Lasinio model. A simple relativistic confining and instantaneous quark model is reviewed. The Salpeter equation for the nucleon and the boosted pion is solved. The f [n pi n] and f[n pi Delta] couplings are calculated and they turn out to be reasonably good. The sensibility of f[n pi n] and f[n pi Delta] to confinement, chiral symmetry breaking and Lorentz invariance is briefly discussed.Comment: 30 pages in LaTex RevTex, 6 postscript figure

Heavy flavor kinetics at the hadronization transition

We investigate the in-medium modification of the charmonium breakup processes due to the Mott effect for light (pi, rho) and open-charm (D, D*) quark-antiquark bound states at the chiral/deconfinement phase transition. The Mott effect for the D-mesons effectively reduces the threshold for charmonium breakup cross sections, which is suggested as an explanation of the anomalous J/psi suppression phenomenon in the NA50 experiment. Further implications of finite-temperature mesonic correlations for the hadronization of heavy flavors in heavy-ion collisions are discussed.Comment: 4 pages, 2 figures, Contribution to SQM2001 Conference, submitted to J. Phys.

Information society: the interaction of tradition and innovation in communicative processes

Scientific novelty of work is in revealing the key aspects of understanding the nature and characteristics of contemporary processes of communication at various levels of socially organized matter, in identifying their most significant features in conditions of the actual information society. The article expresses the view that in modern society, reality is manifested in the form of “normal accidens”, and in this context some of the most illustrative trends of modern social development, that are manifested in various aspects of human activity are highlighted that are the “normal accidents”. It is substantiated that modern network communications are characterized by non-linearity, absence of a core and hierarchy, which affects the dynamics of society. Conclusions. New forms of communication are multidirectional and ambiguous: on the one hand, they are a continuation and a new measurement of the traditionally established forms of public communication and, on the other hand, they are socio-cultural innovations capable of a new influence on the quality of life of an individual, functionality and dynamics of society and its institutions development

Information security in modern society: Sociocultural aspects

The purpose of the work is to study the major conceptual socio-cultural features of the essence and ensuring the information security in an information society. The research methodology is based on a complex combination of philosophical (dialectical, hermeneutical) and scientific methods to study the problem of security in modern society, and especially empirical, comparative, analytical and descriptive. They are based on the principles of consistency and historicity that allows exploring contemporary socio-cultural processes and phenomena in the dynamics and in connection with the historical conditions of their development as well as with the security issues.  The scientific novelty of the work is in revealing key aspects of understanding the essence and ensuring the information security, in defining the most significant features in conditions of the the information society. Conclusions. Ensuring the information security in modern society depends on many factors, including how a person will behave in this or that stressful situation. The key risks factors for the information subsystem of the society are large-scale socio-communicative and socio-cultural transformations, which carry a number of negative social consequences. In recent years, disorganizing and dysfunctional trends, directly related to the high speed of information change are clearly recorded. The traditional practice of information security and security against the information become more complex due to the development of virtual social reality of cyberspace. Modern communication processes lead to the information redundancy and enhance the "fissure" between the virtual and real worlds, which affects the growth of the conventions of network practices of the information security. The overabundance of low quality information, which is observed at this stage of development of the information society is not the only problem of the information security. The problem of forming the appropriate level of information culture that would prevent the emergence of her stressful situations when working with information and information technology is also among such issues. Information security in the information society is the protection of information and protection against the information. Ensuring the information security is a necessity, which becomes an attribute of modern life of any social entity, and requires a tireless work with the information that involves interaction with a variety of expert systems, the delocalization of actions, ensuring freedom and minimizing risks

Repulsive Core of NN S-Wave Scattering in a Quark Model with a Condensed Vacuum

We work in a chiral invariant quark model, with a condensed vacuum, characterized by only one parameter. Bound state equations for the nucleon and Delta are solved in order to obtain an updated value of their radii and masses. Nucleon-nucleon S-Wave scattering is studied in the RGM framework both for isospin T=1 and T=0. The phase shifts are calculated and an equivalent local potential, which is consistent with K-N scattering, is derived. The result is a reasonable microscopic short range repulsion in the nucleon-nucleon interaction.Comment: 23 pages in latex revtex, 4 Postscript figure

Interim analysis of the REASSURE (Radium-223 alpha Emitter Agent in non-intervention Safety Study in mCRPC popUlation for long-teRm Evaluation) study: patient characteristics and safety according to prior use of chemotherapy in routine clinical practice

Purpose: REASSURE is a global, prospective, non-interventional study to assess long-term safety of radium-223 in patients with bone metastatic castration-resistant prostate cancer. Here we report an interim analysis of patients according to previous use of chemotherapy. Methods: Radium-223 was administered in routine clinical practice. Interim safety analysis was planned after enrolment of the first 600 patients. Patient characteristics and safety data by previous administration of chemotherapy (docetaxel and/or cabazitaxel) were investigated. Results: This interim analysis included 583 patients. Median duration of observation was 7 months (range, 0–20). Nineteen patients treated with concomitant chemotherapy were excluded, 564 (97%) were eligible for exploratory analysis according to prior use of chemotherapy; 190 (34%) had previously received and completed chemotherapy, and 374 (66%) had not. In the prior versus no prior chemotherapy group, a higher proportion of patients had an Eastern Cooperative Oncology Group performance status of ≥2 (22% vs 11%) and > 20 metastatic lesions (26% vs 15%), median alkaline phosphatase (162.0 vs 115.0 U/L) and prostate-specific antigen (132.0 vs 40.2 ng/mL) levels were higher, and a lower proportion completed 6 radium-223 injections (45% vs 63%). Drug-related treatment-emergent adverse events (TEAEs) occurred in 63 and 48%, and haematological drug-related TEAEs in 21 and 9% of patients who had or had not previously received chemotherapy. Four drug-related deaths were reported, all in the prior chemotherapy group. Conclusions: The short-term safety profile of radium-223 in routine clinical practice was comparable to other clinical studies, irrespective of prior chemotherapy use. Haematological TEAEs occurred more frequently in the prior chemotherapy group, presumably due to decreased bone marrow function as a consequence of more advanced disease and prior exposure to cytotoxic therapy. Patients who had not previously received chemotherapy appeared to have a lower burden of disease at baseline, and a lower proportion discontinued radium-223 treatment.Purpose: REASSURE is a global, prospective, non-interventional study to assess long-term safety of radium-223 in patients with bone metastatic castration-resistant prostate cancer. Here we report an interim analysis of patients according to previous use of chemotherapy. Methods: Radium-223 was administered in routine clinical practice. Interim safety analysis was planned after enrolment of the first 600 patients. Patient characteristics and safety data by previous administration of chemotherapy (docetaxel and/or cabazitaxel) were investigated. Results: This interim analysis included 583 patients. Median duration of observation was 7 months (range, 0–20). Nineteen patients treated with concomitant chemotherapy were excluded, 564 (97%) were eligible for exploratory analysis according to prior use of chemotherapy; 190 (34%) had previously received and completed chemotherapy, and 374 (66%) had not. In the prior versus no prior chemotherapy group, a higher proportion of patients had an Eastern Cooperative Oncology Group performance status of ≥2 (22% vs 11%) and > 20 metastatic lesions (26% vs 15%), median alkaline phosphatase (162.0 vs 115.0 U/L) and prostate-specific antigen (132.0 vs 40.2 ng/mL) levels were higher, and a lower proportion completed 6 radium-223 injections (45% vs 63%). Drug-related treatment-emergent adverse events (TEAEs) occurred in 63 and 48%, and haematological drug-related TEAEs in 21 and 9% of patients who had or had not previously received chemotherapy. Four drug-related deaths were reported, all in the prior chemotherapy group. Conclusions: The short-term safety profile of radium-223 in routine clinical practice was comparable to other clinical studies, irrespective of prior chemotherapy use. Haematological TEAEs occurred more frequently in the prior chemotherapy group, presumably due to decreased bone marrow function as a consequence of more advanced disease and prior exposure to cytotoxic therapy. Patients who had not previously received chemotherapy appeared to have a lower burden of disease at baseline, and a lower proportion discontinued radium-223 treatment