208 research outputs found
On the Production of Pairs in pp Collisions at 0.8 GeV
Data accumulated recently for the exclusive measurement of the reaction at a beam energy of 0.793 GeV using the COSY-TOF
spectrometer have been analyzed with respect to possible events from the reaction channel. The latter is expected to be the only
production channel, which contains no major contributions from
resonance excitation close to threshold and hence should be a good testing
ground for chiral dynamics in the production process. No single event
has been found, which meets all conditions for being a candidate for the reaction. This gives an upper limit for the cross section of
0.16 b (90% C.L.), which is more than an order of magnitude smaller than
the cross sections of the other two-pion production channels at the same
incident energy
Evaluation of the Validity of SAMe-TT2R2 Score in a Cohort of Venous Thromboembolism Patients Treated With Warfarin
Low SAMe-TT2R2 score of <2 was validated as a predictor of optimum anticoagulation control, reflected by mean time in therapeutic range (TTR) above 65% to 70%, among warfarin-treated atrial fibrillation patients. This study aimed to validate the ability of SAMe-TT2R2 score and its individual components in predicting anticoagulation control (mean TTR and clinical events) among a cohort of venous thromboembolism (VTE) patients in Qatar. A total of 295 patients were retrospectively evaluated. There was a trend toward statistical significance in mean TTR between low (<2) and high (≥ 2) SAMe-TT2R2 score groups (P = .05), a difference that was not sustained when a cutoff of 3 was used (ie, a score of 3 or more). Patients with poor INR control (TTR <70%) were numerically less likely to have SAMe-TT2R2 score of <2 compared with those with good INR control, though the difference was not statistically significant (16.7% vs 83.3%, respectively, P = .4). No thromboembolic events were reported, and no association was found between the score and risk of bleeding. Non-Caucasian origin was the only significant predictor of good anticoagulation in the studied cohort. In conclusion, SAMe-TT2R2 score could not predict quality of anticoagulation control in a cohort of VTE patients treated with warfarin in Qatar. Contribution of other clinical factors and whether a different scoring may yield better prediction of anticoagulation control remains to be tested.The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Medical Research Center in Hamad Medical Corporation. The authors would like to thank Mr Walid Mekkawi and Dr Sayed Yameen, senior pharmacists, for their contribution in data collection. The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Medical Research Center in Hamad Medical Corporation.Scopu
Strong negative self regulation of Prokaryotic transcription factors increases the intrinsic noise of protein expression
Background
Many prokaryotic transcription factors repress their own transcription. It is often asserted that such regulation enables a cell to homeostatically maintain protein abundance. We explore the role of negative self regulation of transcription in regulating the variability of protein abundance using a variety of stochastic modeling techniques.
Results
We undertake a novel analysis of a classic model for negative self regulation. We demonstrate that, with standard approximations, protein variance relative to its mean should be independent of repressor strength in a physiological range. Consequently, in that range, the coefficient of variation would increase with repressor strength. However, stochastic computer simulations demonstrate that there is a greater increase in noise associated with strong repressors than predicted by theory. The discrepancies between the mathematical analysis and computer simulations arise because with strong repressors the approximation that leads to Michaelis-Menten-like hyperbolic repression terms ceases to be valid. Because we observe that strong negative feedback increases variability and so is unlikely to be a mechanism for noise control, we suggest instead that negative feedback is evolutionarily favoured because it allows the cell to minimize mRNA usage. To test this, we used in silico evolution to demonstrate that while negative feedback can achieve only a modest improvement in protein noise reduction compared with the unregulated system, it can achieve good improvement in protein response times and very substantial improvement in reducing mRNA levels.
Conclusions
Strong negative self regulation of transcription may not always be a mechanism for homeostatic control of protein abundance, but instead might be evolutionarily favoured as a mechanism to limit the use of mRNA. The use of hyperbolic terms derived from quasi-steady-state approximation should also be avoided in the analysis of stochastic models with strong repressors
Systematic study of the pp -> pp omega reaction
A systematic study of the production of omega-mesons in
proton-proton-collisions was carried out in a kinematically complete experiment
at three excess energies(epsilon= 92, 128, 173MeV). Both protons were detected
using the large-acceptance COSY-TOF spectrometer at an external beam line at
the Cooler Synchrotron COSY at Forschungszentrum J\"ulich. The total cross
section, angular distributions of both omega-mesons and protons were measured
and presented in various reference frames such as the overall CMS, helicity and
Jackson frame. In addition, the orientation of the omega-spin and invariant
mass spectra were determined. We observe omega-production to take place
dominantly in Ss and Sp final states at epsilon = 92, 128 MeV and,
additionally, in Sd at epsilon= 173 MeV. No obvious indication of resonant
omega-production via N^*-resonances was found, as proton angular distributions
are almost isotropic and invariant mass spectra are compatible with phase space
distributions. A dominant role of ^3P_1 and ^1S_0 initial partial waves for
omega-production was concluded from the orientation of the decay plane of the
omega-meson. Although the Jackson angle distributions in the omega-p-Jackson
frame are anisotropic we argue that this is not an indication of a resonance
but rather a kinematical effect reflecting the anisotropy of the omega angular
distribution. The helicity angle distribution in the omega-p-helicity frame
shows an anisotropy which probably reflects effects of the omega angular
momenta in the final state; this observable may be, in addition to the
orientation of the omega decay plane, the most sensitive one to judge the
validity of theoretical descriptions of the production process.Comment: 17 pages, 16 figures, accepted for publication in EPJ
Single-Pion Production in pp Collisions at 0.95 GeV/c (II)
The single-pion production reactions , and
were measured at a beam momentum of 0.95 GeV/c (
400 MeV) using the short version of the COSY-TOF spectrometer. The central
calorimeter provided particle identification, energy determination and neutron
detection in addition to time-of-flight and angle measurements from other
detector parts. Thus all pion production channels were recorded with 1-4
overconstraints. Main emphasis is put on the presentation and discussion of the
channel, since the results on the other channels have already been
published previously. The total and differential cross sections obtained are
compared to theoretical calculations. In contrast to the channel we
find in the channel a strong influence of the excitation
already at this energy close to threshold. In particular we find a dependence in the pion angular distribution, typical for a
pure s-channel excitation and identical to that observed in the
channel. Since the latter is understood by a s-channel resonance in
the partial wave, we discuss an analogous scenario for the
channel
Production of Lambda and Sigma^0 hyperons in proton-proton collisions
This paper reports results on simultaneous measurements of the reaction
channels pp -> pK+\Lambda and pp -> pK+\Sigma^0 at excess energies of 204, 239,
and 284 MeV (\Lambda) and 127, 162, and 207 MeV (\Sigma^0). Total and
differential cross sections are given for both reactions. It is concluded from
the measured total cross sections that the high energy limit of the cross
section ratio is almost reached at an excess energy of only about 200 MeV. From
the differential distributions observed in the overall CMS as well as in the
Jackson and helicity frames, a significant contribution of interfering nucleon
resonances to the \Lambda production mechanism is concluded while resonant
\Sigma^0-production seems to be of lesser importance and takes place only
through specific partial waves of the entrance channel. The data also indicate
that kaon exchange plays a minor role in the case of \Lambda- but an important
role for \Sigma^0-production. Thus the peculiar energy dependence of the
\Lambda-to-\Sigma^0 cross section ratio appears in a new light as its
explanation requires more than mere differences between the p\Lambda and the
p\Sigma^0 final state interaction. The data provide a benchmark for theoretical
models already available or yet to come.Comment: 18 pages, 10 figures; accepted by The European Physical Journal A
(EPJ A
BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response
Computational modeling and experimentation in the unfolded protein response reveals a role for the ER-resident chaperone protein BiP in fine-tuning the system's response dynamics
Study of omega-meson production in pp collisions at ANKE
The production of omega-mesons in the pp->pp omega reaction has been
investigated with the COSY-ANKE spectrometer for excess energies of 60 and
92MeV by detecting the two final protons and reconstructing their missing mass.
The large multipion background was subtracted using an event-by-event
transformation of the proton momenta between the two energies. Differential
distributions and total cross sections were obtained after careful studies of
possible systematic uncertainties in the overall ANKE acceptance. The results
are compared with the predictions of theoretical models. Combined with data on
the phi-meson, a more refined estimate is made of the Okubo-Zweig-Iizuka rule
violation in the phi/omega production ratio.Comment: 10 pages, 9 figures, version 1, submitted to EPJ-
Two-Pion Production in Proton-Proton Collisions with Polarized Beam
The two-pion production reaction was measured with
a polarized proton beam at 750 and 800 MeV using the short
version of the COSY-TOF spectrometer. The implementation of a delayed pulse
technique for Quirl and central calorimeter provided positive
identification in addition to the standard particle identification, energy
determination as well as time-of-flight and angle measurements. Thus all
four-momenta of the emerging particles could be determined with 1-4
overconstraints. Total and differential cross sections as well as angular
distributions of the vector analyzing power have been obtained. They are
compared to previous data and theoretical calculations. In contrast to
predictions we find significant analyzing power values up to = 0.3
The pK0\Sigma+ final state in proton-proton collisions
This paper reports results from a study of the reaction pp->pK0\Sigma+ at
beam momenta of p_{beam} = 2950, 3059, and 3200 MeV/c (excess energies of
\epsilon= 126, 161, and 206 MeV). Total cross sections were determined for all
energies; a set of differential cross sections (Dalitz plots; invariant mass
spectra of all two-body subsystems; angular distributions of all final state
particles; distributions in helicity and Jackson frames) are presented for
\epsilon= 161 MeV. The total cross sections are proportional to the volume of
available three-body phase-space indicating that the transition matrix element
does not change significantly in this range of excess energies. It is concluded
from the differential data that the reaction proceeds dominantly via the
N(1710)P_{11} and/or N(1720)P_{13} resonance(s); N(1650)S_{11} and
\Delta(1600)P_{33} could also contribute.Comment: 15 pages, 10 figure
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