Additional file 2: Table S1. of Changes in physical functioning among men and women aged 50–79 years in Germany: an analysis of National Health Interview and Examination Surveys, 1997–1999 and 2008–2011

Mean SF-36 physical functioning scores of German National Health Interview and Examination Survey participants 1997–1999 (GNHIES98) and 2008–2011 (DEGS1) included in this analysis by sex, age-groups, survey and covariables. (DOCX 33 kb

Additional file 3: Table S2. of Changes in physical functioning among men and women aged 50–79 years in Germany: an analysis of National Health Interview and Examination Surveys, 1997–1999 and 2008–2011

Multivariable analysis of the absolute change in the mean SF-36 physical functioning subscale score among participants in the German National Health Interview and Examination Survey 1997–1999 (GNHIES98) and 2008–2011 (DEGS1) included in this analysis by sex and age groups including results for all covariables. (DOCX 70 kb

Improving the Solubility of Mn and Suppressing the Oxygen Vacancy Density in Zn_0.98Mn_0.02O Nanocrystals via Octylamine Treatment

Zn_0.98Mn_0.02O nanocrystals were synthesized by the wet chemical route and were treated with different content of octylamine. The environment around Mn and the defect type and concentration were characterized by photoluminescence, Raman, X-ray photoelectron spectroscopy, and X-ray absorption fine structure. It is found that N codoping effectively enhances the solubility of Mn substituting Zn via reducing donor binding energy of impurity by the orbital hybridization between the N-acceptor and Mn-donor. On the other hand, the O atoms released from MnO₆ and the N ions from octylamine occupy the site of oxygen vacancies and result in reduction of the concentration of oxygen vacancies in Zn_0.98Mn_0.02O nanocrystals

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

The analysis of rich catalogues of genetic variation from population-based sequencing provides an opportunity to screen for functional effects. Here we report a rare variant in APOC3 (rs138326449-A, minor allele frequency ∼0.25% (UK)) associated with plasma triglyceride (TG) levels (-1.43 s.d. (s.e.=0.27 per minor allele (P-value=8.0 × 10 -8)) discovered in 3,202 individuals with low read-depth, whole-genome sequence. We replicate this in 12,831 participants from five additional samples of Northern and Southern European origin (-1.0 s.d. (s.e.=0.173), P-value=7.32 × 10 -9). This is consistent with an effect between 0.5 and 1.5 mmol l -1 dependent on population. We show that a single predicted splice donor variant is responsible for association signals and is independent of known common variants. Analyses suggest an independent relationship between rs138326449 and high-density lipoprotein (HDL) levels. This represents one of the first examples of a rare, large effect variant identified from whole-genome sequencing at a population scale