EFFECT OF ANKLE TAPING ON STANDING BALANCE IN THE INDIVIDUALS WITH FUNCTIONAL ANKLE INSTABILITY

Ankle sprain is one of the most common sport injuries in athletes. Based on the epidemiologic investigation (Bahr, 1997), the injury rate of ankle sprain could be 54% in volleyball players, indicating that more than half of the volleyball players has been suffering ankle sprain. The rate of recurrent ankle sprain could be as high as 79% in the volleyball players with ankle sprain. Also, ankle sprain is a common sports injury that can cause significant and chronic disability. Functional instability of the ankle has been defined as a tendency for the foot to give away after an ankle sprain. Such instability is a relatively widespread concern following the acute ankle sprain, persisting as a chronic condition long after the apparent signs and symptoms of the original insult have resolved. Ankle taping has become one of the major interventions in athletic training and is often used for rehabilitation and/or prevention of ankle sprains. Orthotic devices have been shown to effectively modify selected aspects of lower extremity mechanics and improve foot stability during the stance phase of running (Guskiewicz, 1996). Ankle function and muscle coordination after the ankle sprain have been documented (Fu, 2005). However, very little study has been done focusing on the effect of ankle taping on balance control in the individuals with recurrent ankle sprains. Therefore, the purpose of this study was to investigate the effect of ankle taping on the balance ability in the individual with functional ankle instability

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of soluble ST2 (sST2), a decoy receptor for interleukin (IL)-33, increase in patients with mild cognitive impairment, suggesting that impaired IL-33/ST2 signaling may contribute to the pathogenesis of AD. Therefore, we investigated the potential therapeutic role of IL-33 in AD, using transgenic mouse models. Here we report that IL-33 administration reverses synaptic plasticity impairment and memory deficits in APP/PS1 mice. IL-33 administration reduces soluble Aβ levels and amyloid plaque deposition by promoting the recruitment and Aβ phagocytic activity of microglia; this is mediated by ST2/p38 signaling activation. Furthermore, IL-33 injection modulates the innate immune response by polarizing microglia/macrophages toward an antiinflammatory phenotype and reducing the expression of proinflammatory genes, including IL-1β, IL-6, and NLRP3, in the cortices of APP/PS1 mice. Collectively, our results demonstrate a potential therapeutic role for IL-33 in AD

A Novel IoT Based Positioning and Shadowing System for Dementia Training.

A rapid increase in the number of patients with dementia, particularly memory decline or impairment, has led to the loss of self-care ability in more individuals and increases in medical and social costs. Numerous studies, and clinical service experience, have revealed that the intervention of nonpharmacological management for people with dementia is effective in delaying the degeneration caused by dementia. Due to recent rapid developments in information and communications technology, many innovative research and development and cross-domain applications have been effectively used in the dementia care environment. This study proposed a new short-term memory support and cognitive training application technology, a "positioning and shadowing system," to delay short-term memory degeneration in dementia. Training courses that integrate physical and digital technologies for the indoor location of patients with dementia were constructed using technologies such as Bluetooth Low Energy, fingerprint location algorithm, and short-range wireless communication. The Internet of Things was effectively applied to a clinical training environment for short-term memory. A pilot test verified that the results demonstrated learning effects in cognitive training and that the system can assist medical personnel in training and nursing work. Participants responded with favorable feedback regarding course satisfaction and system usability. This study can be used as a reference for future digital smart cognitive training that allows observation of the performance of patients with dementia in activities of daily living

Carbonate mineral saturation states in the East China Sea: present conditions and future scenarios

To assess the impact of rising atmospheric CO₂ and eutrophication on the carbonate chemistry of the East China Sea shelf waters, saturation states (Ω) for two important biologically relevant carbonate minerals – calcite (Ω_c) and aragonite (Ω_a) – were calculated throughout the water column from dissolved inorganic carbon (DIC) and total alkalinity (TA) data collected in spring and summer of 2009. Results show that the highest Ω_c (∼9.0) and Ω_a (∼5.8) values were found in surface water of the Changjiang plume area in summer, whereas the lowest values (Ω_c = ∼2.7 and Ω_a = ∼1.7) were concurrently observed in the bottom water of the same area. This divergent behavior of saturation states in surface and bottom waters was driven by intensive biological production and strong stratification of the water column. The high rate of phytoplankton production, stimulated by the enormous nutrient discharge from the Changjiang, acts to decrease the ratio of DIC to TA, and thereby increases Ω values. In contrast, remineralization of organic matter in the bottom water acts to increase the DIC to TA ratio, and thus decreases Ω values. The projected result shows that continued increases of atmospheric CO₂ under the IS92a emission scenario will decrease Ω values by 40–50% by the end of this century, but both the surface and bottom waters will remain supersaturated with respect to calcite and aragonite. Nevertheless, superimposed on such Ω decrease is the increasing eutrophication, which would mitigate or enhance the Ω decline caused by anthropogenic CO₂ uptake in surface and bottom waters, respectively. Our simulation reveals that, under the combined impact of eutrophication and augmentation of atmospheric CO₂, the bottom water of the Changjiang plume area will become undersaturated with respect to aragonite (Ω_a = ∼0.8) by the end of this century, which would threaten the health of the benthic ecosystem

Rhymes: a shared virtual memory system for non-coherent tiled many-core architectures

The rising core count per processor is pushing chip complexity to a level that hardware-based cache coherency protocols become too hard and costly to scale. We need new designs of many-core hardware and software other than traditional technologies to keep up with the ever-increasing scalability demands. The Intel Single-chip Cloud Computer (SCC) is a recent research processor exemplifying a new cluster-on-chip architecture which promotes a software-oriented approach instead of hardware support to implementing shared memory coherence. This paper presents a shared virtual memory (SVM) system, dubbed Rhymes, tailored to such a new processor kind of non-coherent and hybrid memory architectures. Rhymes features a two-way cache coherence protocol to enforce release consistency for pages allocated in shared physical memory (SPM) and scope consistency for pages in per-core private memory. It also supports page remapping on a per-core basis to boost data locality. We implement Rhymes on the SCC port of the Barrelfish OS. Experimental results show that our SVM outperforms the pure SPM approach used by Intel's software managed coherence (SMC) library by up to 12 times, with superlinear speedups (due to L2 cache effect) noted for applications with strong data reuse patterns.published_or_final_versio

A Simple, Secure and Universal Pancreaticojejunostomy following Pancreaticoduodenectomy

Although the operative mortality of pancreaticoduodenal resection has decreased recently, the operative morbidity resulting from a leaking pancreatic anastomosis remains high. We described our experience in 50 consecutive cases with a simple, secure end to side pancreaticojejunostomy. We used a paediatric nasogastric tube in the pancreatic remnant duct as a temporary external pancreatic drain. There were 29 men and 21 women ranging from 12 to 84 years with a median age of 61 years. Forty-two patients underwent a standard Whipple procedure and eight a pylorus preserving pancreaticoduodenectomy. Average operating time was 270 minutes with a range of 170 to 480 minutes. The pancreaticojejunostomy could be constructed in a mean of 8 minutes. Intraoperative blood loss ranged from 150 to 3500 mL with a mean of 910mL. Twenty-five patients (50 %) received no blood transfusion. The consistency of the pancreatic remnant was hard in 12 patients (24 %) and normal in 38 patients (76 %). The pancreatic duct was dilated (>4mm) in 15 patients (30 %). There was no operative mortality and only three (6.0 %) minor leaks from the pancreatic anastomosis which healed spontaneously. It was difficult to determine if the leaks were related to the consistency of the pancreatic remnant, the size of the pancreatic duct, the amount of intraoperative blood loss, operating time, sex of the patient or experience of the surgeon, as there were only three leaks. We concluded that our technique for pancreaticojejunal anastomosis following pancreaticoduodenectomy was safe and applicable to, standard Whipple or pylorus preserving pancreaticoduodenectomy, small or dilated pancreatic ducts, normal or fibrotic pancreas

A synthetic electric force acting on neutral atoms

Electromagnetism is a simple example of a gauge theory where the underlying potentials -- the vector and scalar potentials -- are defined only up to a gauge choice. The vector potential generates magnetic fields through its spatial variation and electric fields through its time-dependence. We experimentally produce a synthetic gauge field that emerges only at low energy in a rubidium Bose-Einstein condensate: the neutral atoms behave as charged particles do in the presence of a homogeneous effective vector potential. We have generated a synthetic electric field through the time dependence of an effective vector potential, a physical consequence even though the vector potential is spatially uniform

Nanomechanical-resonator-assisted induced transparency in a Cooper-pair-box system

We propose a scheme to demonstrate the electromagnetically induced transparency (EIT) in a system of a superconducting Cooper-pair box coupled to a nanomechanical resonator. In this scheme, the nanomechanical resonator plays an important role to contribute additional auxiliary energy levels to the Cooper-pair box so that the EIT phenomenon could be realized in such a system. We call it here resonator-assisted induced transparency (RAIT). This RAIT technique provides a detection scheme in a real experiment to measure physical properties, such as the vibration frequency and the decay rate, of the coupled nanomechanical resonator.Comment: To appear in New Journal of Physics: Special Issue "Mechanical Systems at the Quantum Limit

The effect of typhoon on particulate organic carbon flux in the southern East China Sea

Severe tropical storms play an important role in triggering phytoplankton blooms, but the extent to which such storms influence biogenic carbon flux from the euphotic zone is unclear. In 2008, typhoon Fengwong provided a unique opportunity to study the in situ biological responses including phytoplankton blooms and particulate organic carbon fluxes associated with a severe storm in the southern East China Sea (SECS). After passage of the typhoon, the sea surface temperature (SST) in the SECS was markedly cooler (∼25 to 26 °C) than before typhoon passage (∼28 to 29 °C). The POC flux 5 days after passage of the typhoon was 265 ± 14 mg C m<sup>−2</sup> d<sup>−1</sup>, which was ∼1.7-fold that (140–180 mg C m<sup>−2</sup> d<sup>−1</sup>) recorded during a period (June–August, 2007) when no typhoons occurred. A somewhat smaller but nevertheless significant increase in POC flux (224–225 mg C m<sup>−2</sup> d<sup>−1</sup>) was detected following typhoon Sinlaku which occurred approximately 1 month after typhoon Fengwong, indicating that typhoon events can increase biogenic carbon flux efficiency in the SECS. Remarkably, phytoplankton uptake accounted for only about 5% of the nitrate injected into the euphotic zone by typhoon Fengwong. It is likely that phytoplankton population growth was constrained by a combination of light limitation and grazing pressure. Modeled estimates of new/export production were remarkably consistent with the average of new and export production following typhoon Fengwong. The same model suggested that during non-typhoon conditions approximately half of the export of organic carbon occurs via convective mixing of dissolved organic carbon, a conclusion consistent with earlier work at comparable latitudes in the open ocean