DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.

Deleted in liver cancer 1 (DLC1) is a RhoGTPase activation protein-containing tumor suppressor that associates with various types of cancer. Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized. Here, we describe the expression and ablation of DLC2 in mice using a reporter-knockout approach. DLC2 is expressed in several tissues and in endothelial cells (ECs) of blood vessels. Although ECs and blood vessels show no histological abnormalities and mice appear overall healthy, DLC2-mutant mice display enhanced angiogenic responses induced by matrigel and by tumor cells. Silencing of DLC2 in human ECs has reduced cell attachment, increased migration, and tube formation. These changes are rescued by silencing of RhoA, suggesting that the process is RhoA pathway dependent. These results indicate that DLC2 is not required for mouse development and normal vessel formation, but may protect mouse from unwanted angiogenesis induced by, for example, tumor cells

Quantum interference by two temporally distinguishable pulses

We report a two-photon interference effect, in which the entangled photon pairs are generated from two laser pulses well-separated in time. In a single pump pulse case, interference effects did not occur in our experimental scheme. However, by introducing a second pump pulse delayed in time, quantum interference was then observed. The visibility of the interference fringes shows dependence on the delay time between two laser pulses. The results are explained in terms of indistinguishability of biphoton amplitudes which originated from two temporally separated laser pulses.Comment: two-column, 4pages, submitted to PRA, minor change

Simulation of valveless micropump and mode analysis

In this work, a 3-D simulation is performed to study for the solid-fluid coupling effect driven by piezoelectric materials and utilizes asymmetric obstacles to control the flow direction. The result of simulation is also verified. For a micropump, it is crucial to find the optimal working frequency which produce maximum net flow rate. The PZT plate vibrates under the first mode, which is symmetric. Adjusting the working frequency, the maximum flow rate can be obtained. For the micrpump we studied, the optimal working frequency is 3.2K Hz. At higher working frequency, say 20K Hz, the fluid-solid membrane may come out a intermediate mode, which is different from the first mode and the second mode. It is observed that the center of the mode drifts. Meanwhile, the result shows that a phase shift lagging when the excitation force exists in the vibration response. Finally, at even higher working frequency, say 30K Hz, a second vibration mode is observed.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/EDA-Publishing

Two-photon interference with thermal light

The study of entangled states has greatly improved the basic understanding about two-photon interferometry. Two-photon interference is not the interference of two photons but the result of superposition among indistinguishable two-photon amplitudes. The concept of two-photon amplitude, however, has generally been restricted to the case of entangled photons. In this letter we report an experimental study that may extend this concept to the general case of independent photons. The experiment also shows interesting practical applications regarding the possibility of obtaining high resolution interference patterns with thermal sources.Comment: Added reference 1

Quantum Teleportation with a Complete Bell State Measurement

We report a quantum teleportation experiment in which nonlinear interactions are used for the Bell state measurements. The experimental results demonstrate the working principle of irreversibly teleporting an unknown arbitrary quantum state from one system to another distant system by disassembling into and then later reconstructing from purely classical information and nonclassical EPR correlations. The distinct feature of this experiment is that \emph{all} four Bell states can be distinguished in the Bell state measurement. Teleportation of a quantum state can thus occur with certainty in principle

Measurement of the Dynamical Structure Factor of a 1D Interacting Fermi Gas

We present measurements of the dynamical structure factor $S(q,\omega)$ of an interacting one-dimensional (1D) Fermi gas for small excitation energies. We use the two lowest hyperfine levels of the $^6$Li atom to form a pseudo-spin-1/2 system whose s-wave interactions are tunable via a Feshbach resonance. The atoms are confined to 1D by a two-dimensional optical lattice. Bragg spectroscopy is used to measure a response of the gas to density ("charge") mode excitations at a momentum $q$ and frequency $\omega$. The spectrum is obtained by varying $\omega$, while the angle between two laser beams determines $q$, which is fixed to be less than the Fermi momentum $k_\textrm{F}$. The measurements agree well with Tomonaga-Luttinger theory

Observation of correlated-photon statistics using a single detector

We report experimental observations of correlated-photon statistics in the single-photon detection rate. The usual quantum interference in a two-photon polarization interferometer always accompanies a dip in the single detector counting rate, regardless of whether a dip or peak is seen in the coincidence rate. This effect is explained by taking into account all possible photon number states that reach the detector, rather than considering just the state post-selected by the coincidence measurement. We also report an interferometeric scheme in which the interference peak or dip in coincidence corresponds directly to a peak or dip in the single-photon detection rate.Comment: 4 pages, two-column (minor errors corrected.

Super-resolving multi-photon interferences with independent light sources

We propose to use multi-photon interferences from statistically independent light sources in combination with linear optical detection techniques to enhance the resolution in imaging. Experimental results with up to five independent thermal light sources confirm this approach to improve the spatial resolution. Since no involved quantum state preparation or detection is required the experiment can be considered an extension of the Hanbury Brown and Twiss experiment for spatial intensity correlations of order N>2

New high-efficiency source of photon pairs for engineering quantum entanglement

We have constructed an efficient source of photon pairs using a waveguide-type nonlinear device and performed a two-photon interference experiment with an unbalanced Michelson interferometer. Parametric down-converted photons from the nonlinear device are detected by two detectors located at the output ports of the interferometer. Because the interferometer is constructed with two optical paths of different length, photons from the shorter path arrive at the detector earlier than those from the longer path. We find that the difference of arrival time and the time window of the coincidence counter are important parameters which determine the boundary between the classical and quantum regime. When the time window of the coincidence counter is smaller than the arrival time difference, fringes of high visibility (80$\pm$ 10%) were observed. This result is only explained by quantum theory and is clear evidence for quantum entanglement of the interferometer's optical paths.Comment: 4 pages, 4 figures, IQEC200