Improving Health Industries by the Supply-Chain Policy

Abstract— the article deals with issues of the policy in the sphere of protection of a Supply-Chain management’s rights and legitimate interests in the health centres. The issues of protection of the rights of Supply-Chain management in the field of health care revealed. In today's global and national economy, businesses are increasingly relying on outsourcing some of their activities and processes. Therefore, more and more companies at the Supply-Chain level, in specific networks, operate and compete with their suppliers and service providers. This process of outsourcing and the growing importance of supply chains has its consequences in the working conditions and health and safety of workers of supply companies and contractors. There are two main networks of Supply-Chain or relationships between companies and members of their supply chain: the main network (a company and suppliers of its specific goods and materials) and the secondary network (a company and its contractors and subcontractors special services such as activities Maintenance, construction, cleaning or catering This report provides an overview, analysis, conclusions and recommendations on how to upgrade health centers through the above Supply-Chain networks

Structure and content of higher professional school lecturer education competence

© 2015, Review of European Studies. All right reserved. Article aims to develop the structure and content of higher professional school lecturer education competence as a lecturer professionalism should be evaluated not only on the quality of the studies, but also for his participation in education activities in higher school. It is needed to rely on a stating that education competence is an integral feature of professional and educational activities aimed at the effectiveness of the educational process in higher professional school in developing its structure and content. In the structure of the lecturer education competence there are four components: humanologic, socio-pedagogical, organizational and methodical, professional personal. Their content is disclosed in knowledge, skills, abilities and personal qualities as necessary for the implementation of the education activities in higher professional school. The presented structure of high school lecturer education competence facilitates the efficient evaluation of the competences, the identification of the gaps in the competencies development levels and their correction with additional measures and means aimed to their effective formation

Клинический случай повторного применения PARP-ингибиторов у больной с mBRCA-ассоциированным раком яичников

Backgraound. High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. The prevalence of BRCA1/2 germline mutations is the highest in HGSOC. patients with germline BRCA gene mutations are more likely to respond to platinum-based chemotherapy. Clinical trials demonstrate the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. Re-administration of PARP inhibitors after response to platinum-based chemotherapy demonstrates an increase in progression-free survival rates regardless of BRCA status. it is important for understanding the development of molecular mechanisms of resistance to platinum drugs and PARP inhibitors, as well as for developing new treatment strategies  and  tools  to  overcome  resistance. Case  description. This  clinical  case  of  BRCA-associated hereditary ovarian cancer demonstrates the efficacy and good tolerability of PARP inhibitor maintenance therapy following the treatment of the first relapse, as well as the efficacy of re-administration of PARP inhibitors following the treatment of the second relapse. The short-course of re-treatment with PARP inhibitors was accompanied by the development of multidrug resistance. the overall survival time was 112 months. Conclusion. The presence of mutations in BRCA1/2 genes is a promising justification for the administration of maintenance therapy with PARP inhibitors. Re-administration of PARP inhibitor maintenance therapy for relapsed ovarian cancer is currently being considered as a possible therapeutic option. deciphering the molecular mechanisms of resistance to PARP inhibitors is of paramount importance for the development of new treatment strategies and tools to overcome chemoresistance, re-sensitization of the tumor to platinum-based drugs or PARP inhibitors.Актуальность. Серозная карцинома высокой степени злокачественности (HG) – наиболее распространенный подтип рака яичника. Частота герминальных мутаций BRCA1,2 наибольшая при HG серозном раке яичников. Пациентки с герминальными мутациями генов BRCA более склонны реагировать на химиотерапию на основе платины. Клинические исследования демонстрируют эффективность PARP-ингибиторов в лечении BRCA-ассоциированного рака яичника. Повторное назначение курсов поддерживающей терапии PARP-ингибиторами после ответа на химиотерапию на основе препаратов платины демонстрирует увеличение выживаемости без прогрессирования независимо от BRCA-статуса и является актуальным для изучения с точки зрения понимания развития молекулярных механизмов резистентности к препаратам платины и ингибиторам PARP, а также с позиций разработки новых методов преодоления резистентности. Описание клинического случая. Данное наблюдение BRCA-ассоциированного наследственного рака яичников демонстрирует эффективность и хорошую переносимость PARP-ингибитора в поддерживающем режиме после терапии первого рецидива на протяжении 37 мес, а также повторное назначение PARP-ингибиторов после лечения второго рецидива. Курс повторной терапии был непродолжительным и сопровождался развитием множественной лекарственной устойчивости. Общая выживаемость составила 112 мес. Заключение. Наличие мутаций генов BRCA1,2 является обоснованием для поддерживающей терапии PARP-ингибиторами, которые рассматриваются в качестве дополнительной опции поддерживающей терапии, улучшающей результаты лечения рака яичников. Повторное назначение PARP-ингибиторов при последующих рецидивах рака яичников рассматривается в качестве возможной терапевтической опции. Расшифровка молекулярных механизмов устойчивости к PARP-ингибиторам имеет значение для разработки новых методов преодоления химиорезистентности, повторного восстановления чувствительности опухоли к препаратам платины или PARP-ингибиторам

Criteria for Differing the Types of Auxiliary Verbs in Korean

In Korean linguistics, the study of auxiliary verbs, beginning with Chhve Hyon Be's study of traditional grammar in the 30s of the 20th century, is still the object of continuous research. This article focuses on the auxiliary verbs in Korean linguistics and the criteria for their differentiation. It examines the subordinate verbs' attachment to the leading verb, and the auxiliary verbs add meaning to the leading verb. The properties of auxiliary verbs are semantically and syntactically dependent on the leading verb, and have aspect and modal meanings. It also clarifies the relation of auxiliary verbs with related forms and the use of similar verbs together with the main verbs

System of Public-private Partnership Financing of Infrastructure Projects

This article discusses the system of public-private partnership financing of infrastructure projects. In addition, measures to expand the use of publicprivate partnership in the country, the adoption of legal acts, the problems associated with the effective implementation of public-private partnership projects were studied

Development of Cognitive Research Activities in Students in Teaching Biology

This article provides information on the organization of a living nature corner and its educational value in the development of cognitive research in extracurricular activities in the teaching of biology in secondary school