Factors Which Related with Eye Fatique (Astenopia) of Computer User at Samsat Office Palembang

Background : The over use of computer will increase risk in eye health (astenopia). The risk factors astenopia are The over use of computer, inadequate lighting intensity increase of age, and frequent of breaks not regularly. Method : The research uses cross sectional design held to 30 computer users in SAMSAT office Palembang. The aim of this research is to know about factors which related with eye fatique. This research uses Questionnaire Luxmeter and reaction timer instruments Result : Based on exact fisher test, there are relation among independent variable and dependen varible (an eye fatique) such us age P value is 0,246, lenght of VDT P value is 0,028 frequent of breaks P value is 0,042 light intensity P value is 0,108 Conclusion : From results of reserach, periodical medical check up especially eye condition must be held regularly. The screen should have been changed with LCD. Filter screen is needed to avoid radiation and increase the level of contrast. Added energy of lamp to increase lighting intensity and the position of monitor must be based on ergonomics factors

PROTECTOR JATEN (PROgram DeTEksi Dini dan Cegah PenyakiT oleh Remaja Jaten) sebagai Upaya Peningkatan Partisipasi Remaja dalam Posbindu PTM di Dusun Jaten, YOGYAKARTA

Latar Belakang: Penyakit tidak menular (PTM) merupakan permasalahan global yang menjadi penyebab utama kematian di dunia. Remaja menjadi kelompok yang rentan karena berada dalam masa perkembangan dan masa pencarian jati diri serta cenderung melakukan perilaku beresiko. Salah satu upaya penanggulangan PTM adalah dengan pelaksanaan Posbindu PTM. Partisipasi remaja sebagai salah satu kelompok sasaran posbindu masih sangat rendah. Hasil kunjungan pelaksanaan Posbindu PTM di dusun jaten menunjukkan dari 38 peserta hanya ada 5 remaja yang mengikuti kegiatan Posbindu PTM. Tujuan: Kegiatan ini bertujuan untuk meningkatkan peran serta remaja dalam kegiatan Posbindu PTM serta untuk mendekatkan akses pelayanan kesehatan bagi remaja. Metode : Metode yang digunakan dalam kegiatan ini diantaranya adalah 1) Melakukan koordinasi dengan para stakeholder yang ada di Dusun Jaten 2) Melakukan koordinasi dengan pihak Puskesmas 3) Melakukan koordinasi dengan ketua pemuda Dusun Jaten 4) Melakukan diskusi baik secara langsung maupun melalui sosial media (grup whatsApp) dengan para remaja 5) Melakukan sosialisasi permasalahan kesehatan kepada para remaja 6) Pembentukan Posbindu remaja 7) Perekrutan kader posbindu remaja 7) Pelaksanaan sekolah kader sebagai bentuk pelatihan bagi para kader Hasil : Pertama, terbentuknya grup whatsApp sebagai sarana diskusi bagi para kader remaja. Kedua, terbentuknya kesepakatan untuk melaksanakan kegiatan Posbindu PTM setiap satu bulan sekali pada pertemuan rutin remaja. Ketiga, terbentuknya kader remaja posbindu sebanyak 14 orang. Keempat, setelah kegiatan Sekolah Kader terdapat peningkatan pengetahuan kader remaja mengenai PTM dan pelaksanaan Posbindu PTM serta peningkatan keterampilan kader remaja dalam melaksanakan pemeriksaan dalam pelaksanaan Posbindu PTM. Kelima, terbentuknya media edukasi berupa filler yang di rancang, dibuat dan dikembangkan oleh para kader remaja. Kesimpulan :Melibatkan remaja secara aktif serta menjalin kerjasama dengan berbagai pihak efektif dalam meningkatkan partisipasi remaja dalam pelaksanaan posbindu PTM di Dusun Jaten. Para kader remaja perlu terus mendapat pendampingan agar terus mendapatkan tambahan pengetahuan dan keterampilan serta agar tetap melaksanaan Posbindu Remaja secara rutin

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat due to its highly invasive nature and heterogeneity. Malignant brain tumor displays high metabolic activity which perturbs its redox environment and in turn translates to high oxidative stress. Thus, pushing the oxidative stress level to achieve the maximum tolerable threshold that induces cell death is a potential strategy for cancer therapy. Previously, we have shown that gap junction inhibitor, carbenoxolone (CBX), is capable of enhancing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis in glioma cells. Since CBX is known to induce oxidative stress, we hypothesized that the addition of another potent mediator of oxidative stress, powerful SOD mimic MnTnBuOE-2-PyP(5+) (MnBuOE), could further enhance TRAIL-driven therapeutic efficacy in glioma cells. Our results showed that combining TRAIL + CBX with MnBuOE significantly enhances cell death of glioma cell lines and this enhancement could be further potentiated by CBX pretreatment. MnBuOE-driven cytotoxicity is due to its ability to take advantage of oxidative stress imposed by CBX + TRAIL system, and enhance it in the presence of endogenous reductants, ascorbate and thiol, thereby producing cytotoxic H2O2, and in turn inducing death of glioma cells but not normal astrocytes. Most importantly, combination treatment significantly reduces viability of TRAIL-resistant Asian patient-derived glioma cells, thus demonstrating the potential clinical use of our therapeutic system. It was reported that H2O2 is involved in membrane depolarization-based sensitization of cancer cells toward TRAIL. MnBuOE is entering Clinical Trials as a normal brain radioprotector in glioma patients at Duke University increasing Clinical relevance of our studies

Paracrine factors of human fetal MSCs inhibit liver cancer growth through reduced activation of IGF-1R/PI3K/Akt signaling

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world. The multikinase inhibitor sorafenib only demonstrated marginal improvement in overall survival for advanced disease prompted the search for alternative treatment options. Human mesenchymal stem cells (MSCs) have the ability to home to tumor cells. However, its functional roles on the tumor microenvironment remain controversial. Herein, we showed that conditioned media derived from human fetal MSC (CM-hfMSCs) expressed high level of the insulin growth factor binding proteins IGFBPs and can sequester free insulin-like growth factors (IGFs) to inhibit HCC cell proliferation. The inhibitory effect of IGFBPs on IGF signaling was further evident from the reduction of activated IGF-1R and PI3K/Akt, leading eventually to the induction of cell cycle arrest. We also demonstrated that CM-hfMSCs could enhance the therapeutic efficacy of sorafenib and sunitinib. To the best of our knowledge, this is the first report to show that CM-hfMSCs has a tumor-specific, antiproliferative effect that is not observed with normal human hepatocyte cells and patient-derived matched normal tissues. Our results thus suggest that CM-hfMSCs can provide a useful tool to design alternative/adjuvant treatment strategies for HCC, especially in related function to potentiate the effects of chemotherapeutic drugs

Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications

10.1038/mt.2014.232Molecular Therapy233510-52