1,689 research outputs found
MicroRNA-23a promotes myelination in the central nervous system.
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-23a-overexpressing mice have increased myelin thickness, providing in vivo evidence that miR-23a enhances both oligodendrocyte differentiation and myelin synthesis. Using this mouse model, we explored possible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kinase/Akt/mammalian target of rapamycin pathway is modulated by miR-23a. Additionally, a long noncoding RNA, 2700046G09Rik, was identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner. The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin
Subcellular localization of Bombyx mori ribosomal protein S3a and effect of its over-expression on BmNPV infection
In the present study, using a BV/PH-Bms3a-EGFP, we found that Bombyx mori ribosomal protein S3a (BmS3a) with EGFP fused to its C-terminal, was predominantly localized in the cytoplasm of B. mori cells. Subsequently, to investigate the effect of BmS3a over-expression on BmNPV infection both at the cellular level and in vivo, a transgenic BmN cell line expressing BmS3a was constructed using a piggybac-A3-EGFP and recombinant baculovirues expressing BmS3a-EGFP fusion protein (BV/IE1-Bms3a-EGFP) or EGFP (BV/EGFP) were produced using BmNPV/Bac-to-Bac expression system. Results showed that the number of polyhedral in the transgenic cells of BmS3a was much smaller than that in non-transgenic cells, and that silkworms injected with BV/IE1-Bms3a-EGFP survived much longer than those injected with BV/EGFP. Taken together, we speculated that BmS3a might be capable of inhibiting BmNPV replication through its activities in the cytoplasm
Best papers of the ACM multimedia systems (MMSys) conference 2017 and the ACM workshop on network and operating system support for digital audio and video (NOSSDAV) 2017
Remote generation of entanglement for individual atoms via optical fibers
The generation of atomic entanglement is discussed in a system that atoms are
trapped in separate cavities which are connected via optical fibers. Two
distant atoms can be projected to Bell-state by synchronized turning off the
local laser fields and then performing a single quantum measurement by a
distant controller. The distinct advantage of this scheme is that it works in a
regime that , which makes the scheme insensitive to
cavity strong leakage. Moreover, the fidelity is not affected by atomic
spontaneous emission.Comment: 4 pages, 3 figure
Soliton Solutions on Noncommutative Orbifold $ T^2/Z_4
In this paper, we explicitly construct a series of projectors on integral
noncommutative orbifold by extended constrution. They include
integration of two arbitary functions with symmetry. Our expressions
possess manifest symmetry. It is proved that the expression include all
projectors with minimal trace and in their standard expansions, the eigen value
functions of coefficient operators are continuous with respect to the arguments
and . Based on the integral expression, we alternately show the
derivative expression in terms of the similar kernal to the integral one.Since
projectors correspond to soliton solutions of the field theory on the
noncommutative orbifold, we thus present a series of corresponding solitons.Comment: 18 pages, no figure; referrences adde
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GPER-induced signaling is essential for the survival of breast cancer stem cells.
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER- /PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER-mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics. Transfection with a dominant-negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs
Exact Analysis of Scaling and Dominant Attractors Beyond the Exponential Potential
By considering the potential parameter as a function of another
potential parameter [47], We successfully extend the analysis of
two-dimensional autonomous dynamical system of quintessence scalar field model
to the analysis of three-dimension, which makes us be able to research the
critical points of a large number of potentials beyond the exponential
potential exactly. We find that there are ten critical points in all, three
points } are general points which are possessed by all
quintessence models regardless of the form of potentials and the rest points
are closely connected to the concrete potentials. It is quite surprising that,
apart from the exponential potential, there are a large number of potentials
which can give the scaling solution when the function
equals zero for one or some values of
and if the parameter also satisfies the condition
Eq.(16) or Eq.(17) at the same time. We give the differential equations to
derive these potentials from . We also find that, if some
conditions are satisfied, the de-Sitter-like dominant point and the
scaling solution point (or ) can be stable simultaneously but
and can not be stable simultaneity. Although we survey scaling
solutions beyond the exponential potential for ordinary quintessence models in
standard general relativity, this method can be applied to other extensively
scaling solution models studied in literature[46] including coupled
quintessence, (coupled-)phantom scalar field, k-essence and even beyond the
general relativity case . we also discuss the disadvantage
of our approach.Comment: 16 pages,no figure, this new revision has taken the suggestions from
CQG referees and has been accepted for publication in Classical and Quantum
Gravit
Critical Behavior and Lack of Self Averaging in the Dynamics of the Random Potts Model in Two Dimensions
We study the dynamics of the q-state random bond Potts ferromagnet on the
square lattice at its critical point by Monte Carlo simulations with single
spin-flip dynamics. We concentrate on q=3 and q=24 and find, in both cases,
conventional, rather than activated, dynamics. We also look at the distribution
of relaxation times among different samples, finding different results for the
two q values. For q=3 the relative variance of the relaxation time tau at the
critical point is finite. However, for q=24 this appears to diverge in the
thermodynamic limit and it is ln(tau) which has a finite relative variance. We
speculate that this difference occurs because the transition of the
corresponding pure system is second order for q=3 but first order for q=24.Comment: 9 pages, 13 figures, final published versio
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