A runtime safety analysis concept for open adaptive systems

© Springer Nature Switzerland AG 2019. In the automotive industry, modern cyber-physical systems feature cooperation and autonomy. Such systems share information to enable collaborative functions, allowing dynamic component integration and architecture reconfiguration. Given the safety-critical nature of the applications involved, an approach for addressing safety in the context of reconfiguration impacting functional and non-functional properties at runtime is needed. In this paper, we introduce a concept for runtime safety analysis and decision input for open adaptive systems. We combine static safety analysis and evidence collected during operation to analyse, reason and provide online recommendations to minimize deviation from a system’s safe states. We illustrate our concept via an abstract vehicle platooning system use case

Generation and quality control of lipidomics data for the alzheimers disease neuroimaging initiative cohort.

Alzheimers disease (AD) is a major public health priority with a large socioeconomic burden and complex etiology. The Alzheimer Disease Metabolomics Consortium (ADMC) and the Alzheimer Disease Neuroimaging Initiative (ADNI) aim to gain new biological insights in the disease etiology. We report here an untargeted lipidomics of serum specimens of 806 subjects within the ADNI1 cohort (188 AD, 392 mild cognitive impairment and 226 cognitively normal subjects) along with 83 quality control samples. Lipids were detected and measured using an ultra-high-performance liquid chromatography quadruple/time-of-flight mass spectrometry (UHPLC-QTOF MS) instrument operated in both negative and positive electrospray ionization modes. The dataset includes a total 513 unique lipid species out of which 341 are known lipids. For over 95% of the detected lipids, a relative standard deviation of better than 20% was achieved in the quality control samples, indicating high technical reproducibility. Association modeling of this dataset and available clinical, metabolomics and drug-use data will provide novel insights into the AD etiology. These datasets are available at the ADNI repository at http://adni.loni.usc.edu/