On the Origin of the Wide HI Absorption Line Toward Sgr A*

We have imaged a region of about 5' extent surrounding Sgr A* in the HI 21 cm-line absorption using the Very Large Array. A Gaussian decomposition of the optical depth spectra at positions within about 2' (approx. 5 pc at 8.5 kpc) of Sgr A* detects a wide line underlying the many narrow absorption lines. The wide line has a mean peak optical depth of 0.32 +/- 0.12 centered at a mean velocity of V(lsr) = -4 +/- 15 km/s. The mean full width at half maximum is 119 +/- 42 km/s. Such a wide line is absent in the spectra at positions beyond about 2' from Sgr A*. The position-velocity diagrams in optical depth reveal that the wide line originates in various components of the circumnuclear disk (radius approx. 1.3') surrounding Sgr A*. These components contribute to the optical depth of the wide line in different velocity ranges. The position-velocity diagrams do not reveal any diffuse feature which could be attributed to a large number of HI clouds along the line of sight to Sgr A*. Consequently, the wide line has no implications either to a global population of shocked HI clouds in the Galaxy or to the energetics of the interstellar medium as was earlier thought.Comment: LaTeX, 12 pages and 9 figures, accepted for publication in J. Astrophys. Ast

The Sasa-Satsuma higher order nonlinear Schrodinger equation and its bilinearization and multi-soliton solutions

Higher order and multicomponent generalizations of the nonlinear Schrodinger equation are important in various applications, e.g., in optics. One of these equations, the integrable Sasa-Satsuma equation, has particularly interesting soliton solutions. Unfortunately the construction of multi-soliton solutions to this equation presents difficulties due to its complicated bilinearization. We discuss briefly some previous attempts and then give the correct bilinearization based on the interpretation of the Sasa-Satsuma equation as a reduction of the three-component Kadomtsev-Petvishvili hierarchy. In the process we also get bilinearizations and multi-soliton formulae for a two component generalization of the Sasa-Satsuma equation (the Yajima-Oikawa-Tasgal-Potasek model), and for a (2+1)-dimensional generalization.Comment: 13 pages in RevTex, added reference

The membrane-embedded segment of cytochrome b5 as studied by cross-linking with photoactivatable phospholipids

Vesicles were prepared from a 9:1 (mole/mol) mixture of dipalmitoyl phosphatidylcholine and the radioactively labeled phospholipids, 1-palmitoyl-2-ω -(m-diazirinophenoxy)undecanoyl-sn-glycero-3-phosphocholine (PC-I) or 1-palmitoyl-2-ω -(2-diazo-3,3,3-trifluropropionyloxy)lauroyl-sn- glycero-3-phosphocholine (PC-II). Rabbit liver cytochrome b5 was inserted into these vesicles spontaneously and the resulting vesicles containing the cytochrome b5 in the transferable form were photolyzed. Cytochrome b5 containing covalently cross-linked phospholipids was isolated by Sephadex LH-60 column chromatography using ethanol/formic acid as the solvent. Of the total radioactivity, 4.6% (PC-I) or 11.3% (PC-II) was linked to the protein; of the former, up to 51% was base-labile, while in the latter, 22% was base-labile. The sites of cross-linking of PC-I to the protein were investigated by fragmentation with trypsin, Staphylococcus aureas V8 protease, CNBr, and o-iodosobenzoic acid followed by Sephadex LH-60 chromatography and Edman sequencing (solid phase) of the appropriate fragments. The distribution of cross-linking was broad (Ser-104 to Met-130), showing a bell-shaped pattern with a significant peak at Ser-118. The labeling pattern is consistent with the previously proposed loop-back model for the membranous segment in the transferable form of cytochrome b5

Engineering functional and anthropomorphic models for surgical training in interventional radiology: A state-of-the-art review

Training medical students in surgical procedures and evaluating their performance are both necessary steps to ensure the safety and efficacy of surgeries. Traditionally, trainees practiced on live patients, cadavers or animals under the supervision of skilled physicians, but realistic anatomical phantom models have provided a low-cost alternative because of the advance of material technology that mimics multi-layer tissue structures. This setup provides safer and more efficient training. Many research prototypes of phantom models allow rapid in-house prototyping for specific geometries and tissue properties. The gel-based method and 3D printing-based method are two major methods for developing phantom prototypes. This study excluded virtual reality based technologies and focused on physical phantoms, total 189 works published between 2015 and 2020 on anatomical phantom prototypes made for interventional radiology were reviewed in terms of their functions and applications. The phantom prototypes were first categorized based on fabrication methods and then subcategorized based on the organ or body part they simulated; the paper is organized accordingly. Engineering specifications and applications were analyzed and summarized for each study. Finally, current challenges in the development of phantom models and directions for future work were discussed

On the method of estimating emission altitude from relativistic phase shift in pulsars

The radiation by relativistic plasma particles is beamed in the direction of field line tangents in the corotating frame, but in an inertial frame it is aberrated toward the direction of rotation. We have revised the relation of aberration phase shift by taking into account of the colatitude of emission spot and the plasma rotation velocity. In the limit of small angle approximation, aberration phase shift becomes independent of the inclination angle alpha and the sight line impact angle beta. However, at larger altitudes or larger rotation phases, the shift does depend on alpha and beta. We have given an expression for the phase shift in the intensity profile by taking into account of aberration, retardation and polar cap currents. We have re-estimated the emission heights of the six classical pulsars, and analyzed the profile of a millisecond pulsar PSR J0437-4715 at 1440 MHz by fitting the Gaussians to pulse components. By this procedure we have been able to identify 11 emission components of PSR J0437-4715. We propose that they form a emission beam with 5 nested cones centered on the core. Using the phase location of component peaks, we have estimated the relativistic phase shift and the emission height of conal components. We find some of the components are emitted from the altitudes as high as 23 percent of light cylinder radius.Comment: 31 pages, 17 Postscript figures, uses aastex.cls, Revised the aberation and retardation phase shift formula

Simultaneous single-pulse observations of radio pulsars: II. Orthogonal polarization modes in PSR B1133+16

In this paper, we present a study of orthogonal polarization modes in the radio emission of PSR B1133+16, conducted within the frame of simultaneous, multi-frequency, single-pulse observations. Simultaneously observing at two frequencies (1.41 GHz and 4.85 GHz) provides the means to study the bandwidth of polarization features such as the polarization position angle. We find two main results. First, that there is a high degree of correlation between the polarization modes at the two frequencies. Secondly, the modes occur more equally and the fractional linear polarization decreases towards higher frequencies. We discuss this frequency evolution and propose propagation effects in the pulsar magnetosphere as its origin.Comment: Accepted for publication in A&A. 5 pages, 4 figure

Does Sub-millisecond Pulsar XTE J1739-285 Contain a Low Magnetic Neutron Star or Quark Star ?

With the possible detection of the fastest spinning nuclear-powered pulsar XTE J1739-285 of frequency 1122 Hz (0.8913 ms), it arouses us to constrain the mass and radius of its central compact object and to imply the stellar matter compositions: neutrons or quarks. Spun-up by the accreting materials to such a high rotating speed, the compact star should have either a small radius or short innermost stable circular orbit. By the empirical relation between the upper kHz quasi-periodic oscillation frequency and star spin frequency, a strong constraint on mass and radius is obtained as 1.51 solar masses and 10.9 km, which excludes most equations of states (EOSs) of normal neutrons and strongly hints the star promisingly to be a strange quark star. Furthermore, the star magnetic field is estimated to be about $4\times10^{7} (G) < B < 10^{9} (G)$, which reconciles with those of millisecond radio pulsars, revealing the clues of the evolution linkage of two types of astrophysical objects.Comment: 10 pages, 2 figures, accepted by PASP 200

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces new proteasome synthesis promoted by the transcription factor RPN4. This ensures that proteasome activity is matched to demand. This transcriptional feedback loop is conserved in mammals, but its molecular basis is not understood. Here, we report that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), a transcription factor of the cap “n” collar basic leucine zipper family, but not the related Nrf2, is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts (MEFs). Promoter-reporter assays revealed the importance of antioxidant response elements in Nrf1-mediated upregulation of proteasome subunit genes. Nrf1^(−/−) MEFs were impaired in the recovery of proteasome activity after transient treatment with the covalent proteasome inhibitor YU101, and knockdown of Nrf1 in human cancer cells enhanced cell killing by YU101. Taken together, our results suggest that Nrf1-mediated proteasome homeostasis could be an attractive target for therapeutic intervention in cancer