Is there any sense in antisense editing?

A number of recent studies have hypothesized that sense-antisense RNA transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. Here we studied human and mouse genomic antisense regions, and found that the editing level in these areas is negligible. This observation puts in question the scope of sense-antisense duplexes formation in-vivo, which is the basis for a number of proposed regulatory mechanisms

Gorenstein homological algebra and universal coefficient theorems

We study criteria for a ring—or more generally, for a small category—to be Gorenstein and for a module over it to be of finite projective dimension. The goal is to unify the universal coefficient theorems found in the literature and to develop machinery for proving new ones. Among the universal coefficient theorems covered by our methods we find, besides all the classic examples, several exotic examples arising from the KK-theory of C*-algebras and also Neeman’s Brown–Adams representability theorem for compactly generated categories

The Universality of Einstein Equations

It is shown that for a wide class of analytic Lagrangians which depend only on the scalar curvature of a metric and a connection, the application of the so--called ``Palatini formalism'', i.e., treating the metric and the connection as independent variables, leads to ``universal'' equations. If the dimension $n$ of space--time is greater than two these universal equations are Einstein equations for a generic Lagrangian and are suitably replaced by other universal equations at bifurcation points. We show that bifurcations take place in particular for conformally invariant Lagrangians $L=R^{n/2} \sqrt g$ and prove that their solutions are conformally equivalent to solutions of Einstein equations. For 2--dimensional space--time we find instead that the universal equation is always the equation of constant scalar curvature; the connection in this case is a Weyl connection, containing the Levi--Civita connection of the metric and an additional vectorfield ensuing from conformal invariance. As an example, we investigate in detail some polynomial Lagrangians and discuss their bifurcations.Comment: 15 pages, LaTeX, (Extended Version), TO-JLL-P1/9

Comparative Study for Inference of Hidden Classes in Stochastic Block Models

Inference of hidden classes in stochastic block model is a classical problem with important applications. Most commonly used methods for this problem involve na\"{\i}ve mean field approaches or heuristic spectral methods. Recently, belief propagation was proposed for this problem. In this contribution we perform a comparative study between the three methods on synthetically created networks. We show that belief propagation shows much better performance when compared to na\"{\i}ve mean field and spectral approaches. This applies to accuracy, computational efficiency and the tendency to overfit the data.Comment: 8 pages, 5 figures AIGM1

Triangle-generation in topological D-brane categories

Tachyon condensation in topological Landau-Ginzburg models can generally be studied using methods of commutative algebra and properties of triangulated categories. The efficiency of this approach is demonstrated by explicitly proving that every D-brane system in all minimal models of type ADE can be generated from only one or two fundamental branes.Comment: 34 page

Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study.

Cerebral small vessel disease (SVD) is a common cause of vascular cognitive impairment. A number of disease features can be assessed on MRI including lacunar infarcts, T2 lesion volume, brain atrophy, and cerebral microbleeds. In addition, diffusion tensor imaging (DTI) is sensitive to disruption of white matter ultrastructure, and recently it has been suggested that additional information on the pattern of damage may be obtained from axial diffusivity, a proposed marker of axonal damage, and radial diffusivity, an indicator of demyelination. We determined the contribution of these whole brain MRI markers to cognitive impairment in SVD. Consecutive patients with lacunar stroke and confluent leukoaraiosis were recruited into the ongoing SCANS study of cognitive impairment in SVD (n = 115), and underwent neuropsychological assessment and multimodal MRI. SVD subjects displayed poor performance on tests of executive function and processing speed. In the SVD group brain volume was lower, white matter hyperintensity volume higher and all diffusion characteristics differed significantly from control subjects (n = 50). On multi-predictor analysis independent predictors of executive function in SVD were lacunar infarct count and diffusivity of normal appearing white matter on DTI. Independent predictors of processing speed were lacunar infarct count and brain atrophy. Radial diffusivity was a stronger DTI predictor than axial diffusivity, suggesting ischaemic demyelination, seen neuropathologically in SVD, may be an important predictor of cognitive impairment in SVD. Our study provides information on the mechanism of cognitive impairment in SVD

An action for supergravity interacting with super-p-brane sources

We describe the coupled system of supergravity and a superbrane source by the sum of the group manifold action for D--dimensional supergravity and the action for a super--$p$--brane. We derive the generalized Einstein equation with the source and discuss the local fermionic symmetries of the coupled action. Our scheme could be especially relevant in $D=11, 10$, in which the superfield actions for supergravity are not known.Comment: One short clarifying comment added. To appear in PRD (Rapid Commun.