91 research outputs found
Nucleosynthesis in Type II Supernovae
Presupernova evolution and explosive nucleosynthesis in massive stars for
main-sequence masses from 13 to 70 are calculated. We
examine the dependence of the supernova yields on the stellar mass,
^{12}C(\alpha, \gamma) ^{16}O} rate, and explosion energy. The supernova
yields integrated over the initial mass function are compared with the solar
abundances.Comment: 1 Page Latex source, 10 PostScript figures, to appear in Nuclear
Physics A, Vol. A616 (1997
Nucleosynthesis in Type Ia Supernovae
Among the major uncertainties involved in the Chandrasekhar mass models for
Type Ia supernovae are the companion star of the accreting white dwarf (or the
accretion rate that determines the carbon ignition density) and the flame speed
after ignition. We present nucleosynthesis results from relatively slow
deflagration (1.5 - 3 % of the sound speed) to constrain the rate of accretion
from the companion star. Because of electron capture, a significant amount of
neutron-rich species such as ^{54}Cr, ^{50}Ti, ^{58}Fe, ^{62}Ni, etc. are
synthesized in the central region. To avoid the too large ratios of
^{54}Cr/^{56}Fe and ^{50}Ti/^{56}Fe, the central density of the white dwarf at
thermonuclear runaway must be as low as \ltsim 2 \e9 \gmc. Such a low central
density can be realized by the accretion as fast as \dot M \gtsim 1 \times
10^{-7} M_\odot yr^{-1}. These rapidly accreting white dwarfs might correspond
to the super-soft X-ray sources.Comment: 10 page LaTeX, 7 PostScript figures, to appear in Nuclear Physics A,
Vol. A621 (1997
PyCOOL - a Cosmological Object-Oriented Lattice code written in Python
There are a number of different phenomena in the early universe that have to
be studied numerically with lattice simulations. This paper presents a graphics
processing unit (GPU) accelerated Python program called PyCOOL that solves the
evolution of scalar fields in a lattice with very precise symplectic
integrators. The program has been written with the intention to hit a sweet
spot of speed, accuracy and user friendliness. This has been achieved by using
the Python language with the PyCUDA interface to make a program that is easy to
adapt to different scalar field models. In this paper we derive the symplectic
dynamics that govern the evolution of the system and then present the
implementation of the program in Python and PyCUDA. The functionality of the
program is tested in a chaotic inflation preheating model, a single field
oscillon case and in a supersymmetric curvaton model which leads to Q-ball
production. We have also compared the performance of a consumer graphics card
to a professional Tesla compute card in these simulations. We find that the
program is not only accurate but also very fast. To further increase the
usefulness of the program we have equipped it with numerous post-processing
functions that provide useful information about the cosmological model. These
include various spectra and statistics of the fields. The program can be
additionally used to calculate the generated curvature perturbation. The
program is publicly available under GNU General Public License at
https://github.com/jtksai/PyCOOL . Some additional information can be found
from http://www.physics.utu.fi/tiedostot/theory/particlecosmology/pycool/ .Comment: 23 pages, 12 figures; some typos correcte
Near-Infrared Properties of Metal-poor Globular Clusters in the Galactic Bulge Direction
Aims. J, H, and K' images obtained from the near-infrared imager CFHTIR on
the Canada-France-Hawaii Telescope are used to derive the morphological
parameters of the red giant branch (RGB) in the near-infrared color-magnitude
diagrams for 12 metal-poor globular clusters in the Galactic bulge direction.
Using the compiled data set of the RGB parameters for the observed 12 clusters,
in addition to the previously studied 5 clusters, we discuss the properties of
the RGB morphology for the clusters and compare them with the calibration
relations for the metal-rich bulge clusters and the metal-poor halo clusters.
Methods. The photometric RGB shape indices such as colors at fixed magnitudes
of MK = MH = (-5.5, -5, -4, and -3), magnitudes at fixed colors of (J - K)o =
(J - H)o = 0.7, and the RGB slope are measured from the fiducial normal points
defined in the near- infrared color-magnitude diagrams for each cluster. The
magnitudes of RGB bump and tip are also estimated from the differential and
cumulative luminosity functions of the selected RGB stars. The derived RGB
parameters have been used to examine the overall behaviors of the RGB
morphology as a function of cluster metallicity. Results. The correlations
between the near-infrared photometric RGB shape indices and the cluster
metallicity for the programme clusters compare favorably with the previous
observational calibration relations for metal-rich clusters in the Galactic
bulge and the metal-poor halo clusters. The observed near-infrared magnitudes
of the RGB bump and tip for the investigated clusters are also in accordance
with the previous calibration relations for the Galactic bulge clusters.Comment: 12 pages, 9 figures, accepted for publication in Astronomy &
Astrophysic
Instabilities and Mixing in SN 1993J
Rayleigh-Taylor (R-T) instabilities in the explosion of SN 1993J are
investigated by means of two-dimensional hydrodynamical simulations. It is
found that the extent of mixing is sensitive to the progenitor's core mass and
the envelope mass. Because the helium core mass (3 - 4 \ms) is smaller than
that of SN 1987A, R-T instabilities at the He/C+O interfaces develop to induce
a large scale mixing in the helium core, while the instability is relatively
weak at the H/He interface due to the small envelope mass. The predicted
abundance distribution, in particular the amount of the \ni~ mixing, is
compared with those required in the theoretical light curves and the late time
optical spectra. This enables us to specify the progenitor of SN 1993J in some
detail.Comment: 20 pages, LaTeX (AASTeX), to appear in Ap
Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results
Intra-arterial (IA) chemotherapy for curative treatment of head and neck cancer experienced a revival in the last decade. Mainly, it was used in concurrent combination with radiation in organ-preserving settings. The modern method of transfemoral approach for catheterisation, superselective perfusion of the tumour-feeding vessel, and high-dose (150βmgβmβ2) administration of cisplatin with parallel systemic neutralisation with sodium thiosulphate (9βgβmβ2) made preoperative usage feasible. The present paper presents the results of a pilot study on a population of 52 patients with resectable stage 1β4 carcinomas of the oral cavity and the oropharynx, who were treated with one cycle of preoperative IA chemotherapy executed as mentioned above and radical surgery. There have been no interventional complications of IA chemotherapy, and acute side effects have been low. One tracheotomy had to be carried out due to swelling. The overall clinical local response has been 69%. There was no interference with surgery, which was carried out 3β4 weeks later. Pathological complete remission was assessed in 25%. The mean observation time was 3 years. A 3-year overall and disease-free survival was 82 and 69%, respectively, and at 5 years 77 and 59%, respectively. Survival results were compared to a treatment-dependent prognosis index for the same population. As a conclusion, it can be stated that IA high-dose chemotherapy with cisplatin and systemic neutralisation in a neoadjuvant setting should be considered a feasible, safe, and effective treatment modality for resectable oral and oropharyngeal cancer. The low toxicity of this local chemotherapy recommends usage especially in stage 1β2 patients. The potential of survival benefit as indicated by the comparison to the prognosis index should be controlled in a randomised study
Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells
The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22
Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to identify cellular genes that were induced by interferon treatment and identified TRIM22 as one of the most strongly up-regulated genes. We confirmed, as in previous studies, that TRIM22 over-expression inhibited HIV replication. To assess the role of TRIM22 expressed under natural inducing conditions, we compared the effects of interferon in cells depleted for TRIM22 using RNAi and found that HIV particle release was significantly increased in the knockdown, implying that TRIM22 acts as a natural antiviral effector. Further studies showed that TRIM22 inhibited budding of virus-like particles containing Gag only, indicating that Gag was the target of TRIM22. TRIM22 did not block the release of MLV or EIAV Gag particles. Inhibition was associated with diffuse cytoplasmic staining of HIV Gag rather than accumulation at the plasma membrane, suggesting TRIM22 disrupts proper trafficking. Mutational analyses of TRIM22 showed that the catalytic amino acids Cys15 and Cys18 of the RING domain are required for TRIM22 antiviral activity. These data disclose a pathway by which Type 1 interferons obstruct HIV replication
Inflammatory cell response to ultra-thin amorphous and crystalline hydroxyapatite surfaces
Divergent Cortical Generators of MEG and EEG during Human Sleep Spindles Suggested by Distributed Source Modeling
Background: Sleep spindles are,1-second bursts of 10β15 Hz activity, occurring during normal stage 2 sleep. In animals, sleep spindles can be synchronous across multiple cortical and thalamic locations, suggesting a distributed stable phaselocked generating system. The high synchrony of spindles across scalp EEG sites suggests that this may also be true in humans. However, prior MEG studies suggest multiple and varying generators. Methodology/Principal Findings: We recorded 306 channels of MEG simultaneously with 60 channels of EEG during naturally occurring spindles of stage 2 sleep in 7 healthy subjects. High-resolution structural MRI was obtained in each subject, to define the shells for a boundary element forward solution and to reconstruct the cortex providing the solution space for a noise-normalized minimum norm source estimation procedure. Integrated across the entire duration of all spindles, sources estimated from EEG and MEG are similar, diffuse and widespread, including all lobes from both hemispheres. However, the locations, phase and amplitude of sources simultaneously estimated from MEG versus EEG are highly distinct during the same spindles. Specifically, the sources estimated from EEG are highly synchronous across the cortex, whereas those from MEG rapidly shift in phase, hemisphere, and the location within the hemisphere. Conclusions/Significance: The heterogeneity of MEG sources implies that multiple generators are active during huma
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