Effective vibrating barriers design for the Zoser pyramid using artificial neural network

Vibrating Barrier (ViBa) is a non-invasive strategy used to protect buildings, especially ancient and historic structures, from seismic wave vibrations. The ViBa is a spring-mass device installed at a separate location beneath the ground surrounding the structure in concern, for the purpose of reducing ground motion energy, without any intervention with the structure itself. The step pyramid of Zoser was one of the archeological monuments affected by the 1992 Earthquake in Egypt. In this work, a new approach of ViBa design is proposed to protect the step pyramid of Zoser using Artificial Neural Network (ANN). A numerical model was developed to test the predicted pyramid seismic behavior using the ANN-derived ViBa parameters. The ANN optimization approach shows a reduction in the peak step pyramid acceleration by 46 %. This reduction was obtained using tuning and optimization of the developed ANN

Modulatory role of vitamins A and E on memory and motor functions of cyanide induced neurotoxicity in adult swiss mice

Summary: Cyanide is a potent neurotoxic substance that can initiate series of intracellular reactions leading to oxidative stress. To evaluate effect of sublethal administration of potassium cyanide (KCN) on sensorimotor functions and long term visuo-spatial learning and memory in adult Swiss mice and possible ameliorative role of vitamins A and E. These vitamins A and E (dietary) are antioxidants that have scavenging properties against free radicals and reactive oxygen species as a result of oxidative stress induced by cyanide. Thirty-five mice weighing between 18-22 g were used for the study. The animals were randomly divided into five groups (n = 7) and exposed to sublethal concentration of potassium cyanide (10% LD50; 1.5 mg/kg). KCN was administered orally while vitamin A (25 mg/kg) and vitamin E (50 mg/kg) were administered intra-peritoneal (IP) once daily for 28 days. Potassium cyanide (KCN) was first administered and after 10 minutes intervals, followed by vitamin A and then E after 5 minutes, vitamin E were administered across the different treatment groups. Mice were examined for signs of toxicity. Vitamins pre-treatment ameliorated toxic signs. In the dynamics of wire grid, coat hanger and stationary beam test, the latency to fall in weeks 2 and 4 were statistically significant. In acquisition and retention, using elevated plus maze (EPM), KCN treated group recorded high transfer latencies in seconds (50.40±1.72 secs) and (57.60±0.93 secs) as compared to group IV (29.40±0.68 secs; 5.60±0.60 secs). Cyanide is a neurotoxin that affects motor functions with progressive decline in motor strength and coordination. KCN affects acquisition and retention memory while pre-treatment with antioxidant vitamins A and E ameliorated these deficits.Keywords: Cyanide; Neurotoxicity; Memory; Motor functionNiger. J. Physiol. Sci. 33(December 2018) 183-18

Ameliorative Effects of Soya Bean Oil and Vitamin C on Liver Enzymes in Ethanol -Induced Oxidative Stress in Wistar Rats

Abstract: The protective potential of soya bean oil and vitamin C on Ethanol-induced oxidative stress i

Sorting by reversals, block interchanges, tandem duplications, and deletions

<p>Abstract</p> <p>Background</p> <p>Finding sequences of evolutionary operations that transform one genome into another is a classic problem in comparative genomics. While most of the genome rearrangement algorithms assume that there is exactly one copy of each gene in both genomes, this does not reflect the biological reality very well – most of the studied genomes contain duplicated gene content, which has to be removed before applying those algorithms. However, dealing with unequal gene content is a very challenging task, and only few algorithms allow operations like duplications and deletions. Almost all of these algorithms restrict these operations to have a fixed size.</p> <p>Results</p> <p>In this paper, we present a heuristic algorithm to sort an ancestral genome (with unique gene content) into a genome of a descendant (with arbitrary gene content) by reversals, block interchanges, tandem duplications, and deletions, where tandem duplications and deletions are of arbitrary size.</p> <p>Conclusion</p> <p>Experimental results show that our algorithm finds sorting sequences that are close to an optimal sorting sequence when the ancestor and the descendant are closely related. The quality of the results decreases when the genomes get more diverged or the genome size increases. Nevertheless, the calculated distances give a good approximation of the true evolutionary distances.</p

Influence of Plant Growth Regulators on Somatic Embryogenesis Induction in Seriphidium herba-album

Seriphidium herba-album (syn. Artemisia herba-alba) is a medicinal, aromatic, greenish-silver herb. It is used widely in folk medicine for treatment of diarrhea, abdominal cramps and in the healing of external wounds. It's also used for the treatment of diabetes mellitus, neurological disorders as epilepsy, Alzheimer's disease, depression and jaundice. In this study we assessed the protocol for callus induction, maturation of somatic embryogenesis, frequency of germination and conversion into plantlets for leaf explants of Seriphidium herba-album using different concentrations of PGRs. Highest induction frequencies of embryogenic calli occurred after 35 days on MS medium supplemented with 1.5 mg L-1 2,4-D and 0.5 mg L-1 BAP. Optimum MS medium for higher frequency of matured somatic embryos was recorded using 5.0 mg L-1 BAP and 0.5 mg L-1 NAA and somatic embryos also induced young in vitro grown plantlets when cultured in the medium containing GA3 and kinetin. Hence, attempts to induce direct somatic embryogenesis have been achieved up to embryo regeneration and maturation

FORMULATION AND ASSESSMENT OF A HERBAL HAIR CREAM AGAINST CERTAIN DERMATOPHYTES

Objective: Developing an herbal antifungal formulation containing eruca and garlic oils against highly resistant dermatophytes (Malassezia fufur AUMC No. 5173, Microsporum canis bodin AUMC No. 5490 and Trichophyton mentagrophytes AUMC No. 5501. 5501) and assessment of garlic oil thiosulfonates during the ex vivo percutaneous permeation through albino rat skin.Methods: Assay of antifungal activity was performed by filter paper disc method and agar well diffusion method. The components of volatile constituents and fixed oil of eruca seeds were studied using GC/MS. Thiosulfinates in garlic oil were analyzed by HPLC/UV. Both oils were incorporated into hair cream using span 60 and brij 58 at three different concentrations (2, 4 and 6% w/w) and alliin, was ex vivo evaluated using albino rat skin mounted on Franz diffusion cells.Results: The two oils have a synergistic effect on the first and additive effect on the second and the third fungi. The main constituents in eruca are 4-(methyl thio) butyl isothiocyanate (82%) for volatile constituents and erucic acid (40%) for the fixed one. The highest flux for alliin (0.337±0.0015 mg/cm2/hr) was obtained at a 4% surfactant concentration.Conclusion: Combination of oils has a high activity on the selected dermatophytes. Formulation of an herbal hair cream using span 60 and Brij 58 with a concentration 4% gives the highest permeation rate for alliin in garlic oil.Keywords: Eruca, Garlic, Dermatophytes, Quantitative determination and Ex-vivo permeatio

Effects of Soya Bean Oil and Vitamin C on Lipid Peroxidation and Antioxidant Biomarkers in Ethanol -Induced Oxidative Stress in Wistar Rats

Abstract: The aim of this experiment is to investigate the effects of Soya bean oil and vitamin C o

Efficient algorithms for analyzing segmental duplications with deletions and inversions in genomes

Background: Segmental duplications, or low-copy repeats, are common in mammalian genomes. In the human genome, most segmental duplications are mosaics comprised of multiple duplicated fragments. This complex genomic organization complicates analysis of the evolutionary history of these sequences. One model proposed to explain this mosaic patterns is a model of repeated aggregation and subsequent duplication of genomic sequences. Results: We describe a polynomial-time exact algorithm to compute duplication distance, a genomic distance defined as the most parsimonious way to build a target string by repeatedly copying substrings of a fixed source string. This distance models the process of repeated aggregation and duplication. We also describe extensions of this distance to include certain types of substring deletions and inversions. Finally, we provide an description of a sequence of duplication events as a context-free grammar (CFG). Conclusion: These new genomic distances will permit more biologically realistic analyses of segmental duplications in genomes.

Detection violent behaviors: A survey

Violence detection behavior is a particular problem regarding the great problem action recognition. In recent years, the detection and recognition of violence has been studied for several applications, namely in surveillance. In this paper, we conducted a recent systematic review of the literature on this subject, covering a selection of various researched papers. The selected works were classified into three main approaches for violence detection: video, audio, and multimodal audio and video. Our analysis provides a roadmap to guide future research to design automatic violence detection systems. Techniques related to the extraction and description of resources to represent behavior are also reviewed. Classification methods and structures for behavior modelling are also provided.European Structural and Investment Funds in the FEDER component, through the Operational Competitiveness and Internationalization Programme (COMPETE 2020) [Project n ∘ 039334; Funding Reference: POCI-01-0247-FEDER-039334]. This work has been supported by national funds through FCT – Fundação para a Ciência e Tecnologia through project UIDB/04728/202

Estimating true evolutionary distances under rearrangements, duplications, and losses

Background: The rapidly increasing availability of whole-genome sequences has enabled the study of whole-genome evolution. Evolutionary mechanisms based on genome rearrangements have attracted much attention and given rise to many models; somewhat independently, the mechanisms of gene duplication and loss have seen much work. However, the two are not independent and thus require a unified treatment, which remains missing to date. Moreover, existing rearrangement models do not fit the dichotomy between most prokaryotic genomes (one circular chromosome) and most eukaryotic genomes (multiple linear chromosomes). Results: To handle rearrangements, gene duplications and losses, we propose a new evolutionary model and the corresponding method for estimating true evolutionary distance. Our model, inspired from the DCJ model, is simple and the first to respect the prokaryotic/eukaryotic structural dichotomy. Experimental results on a wide variety of genome structures demonstrate the very high accuracy and robustness of our distance estimator. Conclusions: We give the first robust, statistically based, estimate of genomic pairwise distances based on rearrangements, duplications and losses, under a model that respects the structural dichotomy between prokaryotic and eukaryotic genomes. Accurate and robust estimates in true evolutionary distances should translate into much better phylogenetic reconstructions as well as more accurate genomic alignments, while our new model of genome rearrangements provides another refinement in simplicity and verisimilitude