Radiative corrections to the lattice gluon action for highly improved staggered quarks (HISQ) and the effect of such corrections on the static potential

We perform a perturbative calculation of the influence of dynamical HISQ fermions on the perturbative improvement of the gluonic action in the same way as we have previously done for asqtad fermions. We find the fermionic contributions to the radiative corrections in the Luescher-Weisz gauge action to be somewhat larger for HISQ fermions than for asqtad. Using one-loop perturbation theory as a test, we estimate that omission of the fermion-induced radiative corrections in dynamical asqtad simulations will give a measurable effect. The one-loop result gives a systematic shift of about -0.6% in (r_1/a) on the coarsest asqtad improved staggered ensembles. This is the correct sign and magnitude to explain the scaling violations seen in Phi_B on dynamical lattice ensembles.Comment: 10 pages, 5 figures. Minor corrections suggested by refere

Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.

OBJECTIVES: The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs). METHODS: The report included workers exposed to diesel exhausts (low PAH exposure level, n = 39) as well as those exposed to emissions from asphalt (medium PAH exposure level, n = 26) and coke ovens (high PAH exposure level, n = 28). Levels of Nap and Phe were measured in urine from each subject using head space-solid phase microextraction and gas chromatography-mass spectrometry. Published levels of airborne Nap, Phe and other PAHs in the coke-producing and aluminium industries were also investigated. RESULTS: In post-shift urine, the highest estimated geometric mean concentrations of Nap and Phe were observed in coke-oven workers (Nap: 2490 ng/l; Phe: 975 ng/l), followed by asphalt workers (Nap: 71.5 ng/l; Phe: 54.3 ng/l), and by diesel-exposed workers (Nap: 17.7 ng/l; Phe: 3.60 ng/l). After subtracting logged background levels of Nap and Phe from the logged post-shift levels of these PAHs in urine, the resulting values (referred to as ln(adjNap) and ln(adjPhe), respectively) were significantly correlated in each group of workers (0.71 < or = Pearson r < or = 0.89), suggesting a common exposure source in each case. Surprisingly, multiple linear regression analysis of ln(adjNap) on ln(adjPhe) showed no significant effect of the source of exposure (coke ovens, asphalt and diesel exhaust) and further suggested that the ratio of urinary Nap/Phe (in natural scale) decreased with increasing exposure levels. These results were corroborated with published data for airborne Nap and Phe in the coke-producing and aluminium industries. The published air measurements also indicated that Nap and Phe levels were proportional to the levels of all combined PAHs in those industries. CONCLUSION: Levels of Nap and Phe in urine reflect airborne exposures to these compounds and are promising surrogates for occupational exposures to PAH mixtures

Light scalars in strongly-coupled extra-dimensional theories

The low-energy dynamics of five-dimensional Yang-Mills theories compactified on S^1 can be described by a four-dimensional gauge theory coupled to a scalar field in the adjoint representation of the gauge group. Perturbative calculations suggest that the mass of this elementary scalar field is protected against power divergences, and is controlled by the size of the extra dimension R. As a first step in the study of this phenomenon beyond perturbation theory, we investigate the phase diagram of a SU(2) Yang-Mills theory in five dimensions regularized on anisotropic lattices and we determine the ratios of the relevant physical scales. The lattice system shows a dimensionally reduced phase where the four-dimensional correlation length is much larger than the size of the extra dimension, but still smaller than the four-dimensional volume. In this region of the bare parameter space, at energies below 1/R, the non-perturbative spectrum contains a \emph{light} scalar state. This state has a mass that is independent of the cut-off, and a small overlap with glueball operators. Our results suggest that light scalar fields can be introduced in a lattice theory using compactified extra dimensions, rather than fine tuning the bare mass parameter.Comment: 38 pages (7 pages of Appendix), 10 tables, 21 figures. Minor corrections. Version accepted for publication in JHE

lin-12 Notch functions in the adult nervous system of C. elegans

BACKGROUND: Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion. RESULTS: The spontaneous reversal rate of C. elegans during normal locomotion is constant. Both lin-12 gain and loss of function mutant animals had significantly increased reversal rates compared to wild type controls. These defects were caused by lin-12 activity, because the loss of function defect could be rescued by a wild type lin-12 transgene. Furthermore, overexpression of lin-12 recapitulated the gain-of-function defect. Increasing or decreasing lin-12 activity in the postdevelopmental adult animal was sufficient to rapidly and reversibly increase reversals, thereby excluding a developmental role for lin-12. Although lin-12 is expressed in the vulval and somatic gonad lineages, we find that these tissues play no role in regulating reversal rates. In contrast, altering lin-12 activity specifically in the nervous system was sufficient to increase reversals. These behavioral changes require components of the canonical lin-12 signaling cascade, including the ligand lag-2 and the transcriptional effector lag-1. Finally, the C. elegans AMPA/kainate glutamate receptor homolog glr-1 shows strong genetic interactions with lin-12, suggesting that glr-1 and/or other glutamate gated channels may be targets of lin-12 regulation. CONCLUSION: Our results demonstrate a neuronal role for lin-12 Notch in C. elegans and suggest that lin-12 acutely regulates neuronal physiology to modulate animal behavior, without altering neuronal cell fate specification or neurite outgrowth. This is consistent with a role for Notch signaling in neurological disease with late onset symptoms

Intermediate distance correlators in hot Yang-Mills theory

Lattice measurements of spatial correlation functions of the operators FF and FF-dual in thermal SU(3) gauge theory have revealed a clear difference between the two channels at "intermediate" distances, x ~ 1/(pi T). This is at odds with the AdS/CFT limit which predicts the results to coincide. On the other hand, an OPE analysis at short distances (x << 1/(pi T)) as well as effective theory methods at long distances (x >> 1/(pi T)) suggest differences. Here we study the situation at intermediate distances by determining the time-averaged spatial correlators through a 2-loop computation. We do find unequal results, however the numerical disparity is small. Apart from theoretical issues, a future comparison of our results with time-averaged lattice measurements might also be of phenomenological interest in that understanding the convergence of the weak-coupling series at intermediate distances may bear on studies of the thermal broadening of heavy quarkonium resonances.Comment: 31 page

Modeling Progressive Failure of Bonded Joints Using a Single Joint Finite Element

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90634/1/AIAA-55313-740.pd

A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation

Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants. The dynamic supramolecular polyurethane (SPU) is able to self-assemble through hydrogen bonding and π-π stacking interactions, resulting in an addressable polymer network with a relatively low processing temperature. The mechanical properties of the SPU demonstrated the material was self-supporting, stiff, yet flexible thus making it suitable for hot-melt extrusion processing, inclusive of related 3D printing approaches. Cell-based toxicity assays revealed the SPU to be non-toxic and therefore a viable candidate as a biocompatible polymer for implant applications. To this end, the SPU was formulated with paracetamol (16 %w/w) and 4 wt% or 8 wt% poly(ethylene glycol) (PEG) as an excipient and hot melt extruded at 100 °C to afford a 3D printed prototype implant to explore the extended drug release required for an implant and the potential manipulation of the release profile. Furthermore, rheological, infra-red spectroscopy, powder X-ray diffraction and scanning electron microscopy studies revealed the chemical and physical properties and compatibility of the formulation components. Successful release of paracetamol was achieved from in vitro dissolution studies and it was predicted that the drug would be released over a period of up to 8.5 months with hydrophilic PEG being able to influence the release rate. This extended release time is consistent with applications of this novel dynamic polymer as a drug eluting implant matrix

Nonlinear Regge trajectories and glueballs

We apply a phenomenological approach based on nonlinear Regge trajectories to glueball states. The parameters, i.e., intercept and threshold, or trajectory termination point beyond which no bound states should exist, are determined from pomeron (scattering) data. Systematic errors inherent to the approach are discussed. We then predict masses of glueballs on the tensor trajectory. For comparison, the approach is applied to available quenched lattice data. We find a discrepancy between the lattice based thresholds and the pomeron threshold that we extract from data.Comment: 15pp., revtex4, 2 fig

Confining strings in SU(N) gauge theories

We calculate the string tensions of $k$-strings in SU($N$) gauge theories in both 3 and 4 dimensions. In D=3+1, we find that the ratio of the $k=2$ string tension to the $k = 1$ fundamental string tension is consistent, at the $2 \sigma$ level, with both the M(-theory)QCD-inspired conjecture and with `Casimir scaling'. In D=2+1 we see a definite deviation from the MQCD formula, as well as a much smaller but still significant deviation from Casimir scaling. We find that in both D=2+1 and D=3+1 the high temperature spatial $k$-string tensions also satisfy approximate Casimir scaling. We point out that approximate Casimir scaling arises naturally if the cross-section of the flux tube is nearly independent of the flux carried, and that this will occur in an effective dual superconducting description, if we are in the deep-London limit. We estimate, numerically, the intrinsic width of $k$-strings in D=2+1 and indeed find little variation with $k$. In addition to the stable $k$-strings we investigate some ofthe unstable strings, finding in D=2+1 that they satisfy (approximate) Casimir scaling. We also investigate the basic assumption that confining flux tubes are described by an effective string theory at large distances. We estimate the coefficient of the universal L\"uscher correction from periodic strings that are longer than 1 fermi, and find $c_L=0.98(4)$ in D=3+1 and $c_L=0.558(19)$ in D=2+1. These values are within $2 \sigma$ of the simple bosonic string values and are inconsistent with other simple effective string theories.Comment: 57 pages, 11 figures. Errors on fits reduced by altering the analysis to a standard one. Conclusions unchanged; note addedchanged. Some typos correcte

Coffee consumption and prostate cancer risk: further evidence for inverse relationship

<p>Abstract</p> <p>Background</p> <p>Higher consumption of coffee intake has recently been linked with reduced risk of aggressive prostate cancer (PC) incidence, although meta-analysis of other studies that examine the association between coffee consumption and overall PC risk remains inconclusive. Only one recent study investigated the association between coffee intake and grade-specific incidence of PC, further evidence is required to understand the aetiology of aggressive PCs. Therefore, we conducted a prospective study to examine the relationship between coffee intake and overall as well as grade-specific PC risk.</p> <p>Methods</p> <p>We conducted a prospective cohort study of 6017 men who were enrolled in the Collaborative cohort study in the UK between 1970 and 1973 and followed up to 31st December 2007. Cox Proportional Hazards Models were used to evaluate the association between coffee consumption and overall, as well as Gleason grade-specific, PC incidence.</p> <p>Results</p> <p>Higher coffee consumption was inversely associated with risk of high grade but not with overall risk of PC. Men consuming 3 or more cups of coffee per day experienced 55% lower risk of high Gleason grade disease compared with non-coffee drinkers in analysis adjusted for age and social class (HR 0.45, 95% CI 0.23-0.90, p value for trend 0.01). This association changed a little after additional adjustment for Body Mass Index, smoking, cholesterol level, systolic blood pressure, tea intake and alcohol consumption.</p> <p>Conclusion</p> <p>Coffee consumption reduces the risk of aggressive PC but not the overall risk.</p