25 research outputs found
Exploring Options for Enhancement of Social Dialogue Between the Turkish and Greek Communities in Cyprus Using the Structured Dialogic Design Process
Is Autism, Attention Deficit Hyperactivity Disorder (ADHD) and Specific Learning Disorder linked to Impaired Emotion Recognition in Primary School Aged Children?
The Political Economy of Death in the Age of Information: A Critical Approach to the Digital Afterlife Industry
Systemic evaluation of actions toward developing practical broadband applications for elderly and people with disabilities
ReineventDemocracyAfricaRCMD
The file contains the raw data from the African Structured Democraric Dialogu
Can Information and Mobile Technologies Serve to Close the Economic, Educational, Digital, and Social gaps and Accelerate Development?
Does motoneuron adaptation contribute to muscle fatigue?
Published in Muscle & Nerve, 2007; 35 (2):135-158 at www.interscience.wiley.comTo help reduce the gap between the cellular physiology of motoneurons (MNs) as studied "bottom-up" in animal preparations and the "top-down" study of the firing patterns of human motor units (MUs), this article addresses the question of whether motoneuron adaptation contributes to muscle fatigue. Findings are reviewed on the intracellularly recorded electrophysiology of spinal MNs as studied in vivo and in vitro using animal preparations, and the extracellularly recorded discharge of MUs as studied in conscious humans. The latter "top-down" approach, combined with kinetic measurements, has provided most of what is currently known about the neurobiology of muscle fatigue, including its task and context dependencies. It is argued that although the question addressed is still open, it should now be possible to design new "bottom-up" research paradigms using animal preparations that take advantage of what has been learned with the use of relatively noninvasive quantitative procedures in conscious humans.Michael A. Nordstrom, Robert B. Gorman, Yiannis Laouris, John M. Spielmann and Douglas G. Stuar