The NTI-tss device for the therapy of bruxism, temporomandibular disorders, and headache – Where do we stand? A qualitative systematic review of the literature

<p>Abstract</p> <p>Background</p> <p>The NTI-tss device is an anterior bite stop, which, according to the manufacturer, is indicated for the prevention and treatment of bruxism, temporomandibular disorders (TMDs), tension-type headaches, and migraine. The aim of this systematic review was to appraise the currently available evidence regarding the efficacy and safety of the NTI-tss splint.</p> <p>Methods</p> <p>We performed a systematic search in nine electronic databases and in NTI-tss-associated websites (last update: December 31, 2007). The reference lists of all relevant articles were perused. Five levels of scientific quality were distinguished. Reporting quality of articles about randomized controlled trials (RCTs) was evaluated using the Jadad score. To identify adverse events, we searched in the identified publications and in the MAUDE database.</p> <p>Results</p> <p>Nine of 68 relevant publications reported about the results of five different RCTs. Two RCTs concentrated on electromyographic (EMG) investigations in patients with TMDs and concomitant bruxism (Baad-Hansen et al 2007, Jadad score: 4) or with bruxism alone (Kavaklı 2006, Jadad score: 2); in both studies, compared to an occlusal stabilization splint the NTI-tss device showed significant reduction of EMG activity. Two RCTs focused exclusively on TMD patients; in one trial (Magnusson et al 2004, Jadad score: 3), a stabilization appliance led to greater improvement than an NTI-tss device, while in the other study (Jokstad et al 2005, Jadad score: 5) no difference was found. In one RCT (Shankland 2002, Jadad score: 1), patients with tension-type headache or migraine responded more favorably to the NTI-tss splint than to a bleaching tray. NTI-tss-induced complications related predominantly to single teeth or to the occlusion.</p> <p>Conclusion</p> <p>Evidence from RCTs suggests that the NTI-tss device may be successfully used for the management of bruxism and TMDs. However, to avoid potential unwanted effects, it should be chosen only if certain a patient will be compliant with follow-up appointments. The NTI-tss bite splint may be justified when a reduction of jaw closer muscle activity (e.g., jaw clenching or tooth grinding) is desired, or as an emergency device in patients with acute temporomandibular pain and, possibly, restricted jaw opening.</p

The Role of Pediatric Bleeding Questionnaire in The Diagnosis of Von Willebrand Disease in Children

[No abstract available

AML hastalarında t(15;17) PML-RARA translokasyonunun real time RT-PCR ile 5 yıllık sonuçlarının değerlendirilmesi

Aim: Acute promyelocytic leukemia (APL) is a well-defined subtype of acute myeloid leukemia (AML) specifically characterized by the t(15;17)(q22;q12) translocation. t(15;17) results in the fusion of the genes, promyelocytic leukemia (PML) on chromosome 15 and retinoic acid receptor alpha (RARA) located on 17th chromosome. Translocation is detected by conventional cytogenetic, fluorescence in situ hybridization analyses (FISH) and often a real time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) method. In this study, quantification of t(15; 17) translocation via real time qRT-PCR was aimed in blood or bone marrow materials belonging to APL pre-diagnosed cases that appealed our department. Materials and Methods: Seventy nine children (7.28 ;plusmn; 5.20 years; 45 M, 34 F) and 359 adults (47.71 ;plusmn; 15.57 years; 193 M, 166 F) were included in the study between the years 2009-2013. Following total RNA isolation from blood or bone marrow materials of the cases, cDNA synthesis was carried out. Then, t(15; 17) translocation was studied by qRT-PCR and quantitated. Results: Two cases from children (3%), and in total 6 tests (5%) were detected positive for t(15;17). The average t(15;17) quantification value was 0.0002 ;plusmn; 0.0003. Twenty six cases of the adults (7%), in total 30 tests (8%) were determined as t(15;17) positive. Average t(15;17) quantification value of these cases was 0.067 ;plusmn; 0.144. Conclusion: The superiority of qRT-PCR compared to conventional cytogenetic studies can be found in the fact that all working steps can be monitored simultaneously during the test and the resulting amplicons can be quantitated. The clinical significance of t(15;17) qualitative determination is, confirmation of the diagnosis, all trans-retinoic acid and trioxide arsenic treatment response prediction and treatment efficacy knowledge in addition to minimal residual disease (MRD) monitoring and ability to identify relapse at early ages.Amaç: Akut promyelösitik lösemi (APL), akut myeloid löseminin (AML) iyi tanımlanmış alt tipidir ve spesifik olarak t(15;17)(q22;q12) translokasyonu ile karakterizedir. t(15;17), 15. kromozom üzerinde bulunan promyelösitik lösemi (PML) ve 17. kromozomda lokalize retinoik asit reseptör alfa (RARA) genlerinin füzyonu sonucu oluşur. Translokasyon varlığı, konvansiyonel sitogenetik, floresan in situ hibridizasyon analizi (FISH) ve sıklıkla gerçek zamanlı kantitatif revers transkriptaz polimeraz zincir reaksiyonu (qRT-PCR) yöntemiyle saptanır. Bu çalışmada, anabilim dalımıza başvuran APL ön tanılı olgulara ait kan ya da kemik iliği materyallerinden t(15;17) translokasyonunun gerçek zamanlı qRT-PCR ile kantitasyonu amaçlanmıştır. Gereç ve Yöntem: Çalışmaya 2009-2013 yılları arasında başvuran 79 çocuk (7.28±5.20 yaş; 45 E, 34 K) ve 359 yetişkin (47.71±15.57 yaş; 193 E, 166 K) olgu dahil edilmiştir. Olguların kan ya da kemik iliği materyallerinden total RNA izolasyonunu takiben cDNA sentezi gerçekleştirilmiştir. Sonrasında, qRT-PCR ile t(15;17) translokasyonu çalışılıp, kantite edilmiştir. Bulgular: Çocuk olgulardan 2'si (%3), toplamda 6 test (%5) t(15;17) için pozitif olarak belirlenmiştir. Bu olgulara ait t(15;17) kantitasyon değeri ortalaması, 0.0002±0.0003’tür. Yetişkin olguların 26'sı (%7), toplamda 30 test (%8) t(15;17) için pozitif olarak belirlenmiştir. Bu olgulara ait t(15;17) kantitasyon değeri ortalaması, 0.067±0,144’tür. Sonuç: qRT-PCR’ın konvensiyonel sitogenetik çalışmalara göre üstünlüğü, tüm çalışma basamaklarının test esnasında eş zamanlı olarak izlenebilmesi ve oluşan amplikonların kantitasyonunun yapılabilmesidir. t(15;17) kalitatif tayininin klinikteki önemi, tanının kesinleştirilmesinde, tüm trans-retinoik asit ve trioksid arsenik tedavisine yanıtın öngörülmesi ve tedavinin yararlılığının bilinmesinde, minimal rezidüel hastalığın (MRH) takibi ve relapsın erken evrede belirlenebilmesidir

Fears of compassion magnify the harmful effects of threat of COVID-19 on mental health and social safeness across 21 countries

The COVID-19 pandemic is a massive global health crisis with damaging consequences to mental health and social relationships. Exploring factors that may heighten or buffer the risk of mental health problems in this context is thus critical. Whilst compassion may be a protective factor, in contrast fears of compassion increase vulnerability to psychosocial distress and may amplify the impact of the pandemic on mental health. This study explores the magnifying effects of fears of compassion on the impact of perceived threat of COVID-19 on depression, anxiety and stress, and social safeness. Adult participants from the general population (N = 4057) were recruited across 21 countries worldwide, and completed self-report measures of perceived threat of COVID-19, fears of compassion (for self, from others, for others), depression, anxiety, stress and social safeness. Perceived threat of COVID-19 predicted increased depression, anxiety and stress. The three flows of fears of compassion predicted higher levels of depression, anxiety and stress and lower social safeness. All fears of compassion moderated (heightened) the impact of perceived threat of COVID-19 on psychological distress. Only fears of compassion from others moderated the effects of likelihood of contracting COVID-19 on social safeness. These effects were consistent across all countries. Fears of compassion have a universal magnifying effect on the damaging impact of the COVID-19 pandemic on mental health and social safeness. Compassion focused interventions and communications could be implemented to reduce resistances to compassion and promote mental wellbeing during and following the pandemic.SFRH/BD/130677/2017/Portuguese Foundation for Science and Technology UID/PSI/00730/2020/Portuguese Foundation for Science and Technology PP-COVID-20-0074/Slovak Research and Development Agency 1/0075/19/Vedecká grantová agentúra MšVVaš SR a SAV 435-2017-0062/Social Sciences and Humanities Research Council Insight Gran