Paleoflooding reconstruction from Holocene levee deposits in the Lower Meuse valley, the Netherlands

This study investigates the Holocene levee deposits and paleoflooding history of the Lower Meuse in the Netherlands based on archeological investigations and sedimentary analyses (grain size, end-member modelling, magnetic susceptibility and thermogravimetric analyses). The levee on the left bank in the study area near Ooijen contains a continuous sedimentary record in the NW downstream part. The archeological evidence and sedimentary results, including a grain size based flood energy index (LFEI), indicate that the Lower Meuse experienced a quiescent flooding period and low sedimentation rates during the mid-late Mesolithic when the levee was low and human influence was minor. Deposition during the Mesolithic shows a fining-upward trend and a highly-developed soil containing abundant artefacts. During the Neolithic and Bronze Age, the flooding intensity was low but gradually increased to a moderate level probably because of deforestation and increased runoff. Limited Bronze Age findings may reflect decreased human activity because of the increased flooding. Starting from the Iron Age, the Meuse experienced a generally enhanced flooding regime, which is reflected by erosion and coarsened sedimentation in the Iron Age and Roman Period. The high peak discharges during the Iron Age may have re-opened a low-lying paleochannel near to the levee during the intensified floods. This general increasing trend is interrupted by the lower flooding phase in the early Middle Ages (Dark Ages). From the middle to the late Middle Ages, the floods intensified again. The coarsening deposition and higher sedimentation rates since the Iron Age resulted from increased floods and higher sediment supply by deforestation and soil erosion. The findings of this study agree with a recent paleoflood reconstruction for the Lower Meuse by using a floodplain archive, implying that levee sediment records have potential in paleohydrological studies if the completeness of the record and chronological information is guaranteed

The value of prognostic clinical data in Bell’s palsy

SummaryElectroneurography (ENoG) and clinical staging are currently the methods of choice to indicate prognosis in Bell’s palsy, although ENoG is an electrophysiological test not universally available. Aim: Identify other options of prognostic evaluation based upon clinical aspects and minimal electrical stimulation test allowing prognostic measurement in almost any circumstances. Study design: historic cohort. Material and Method: Chart review of 1,521 cases of IPFP, analyzing the following clinical aspects: gender, age, paralyzed side, installation mode, previous symptoms, associated symptoms and minimal electrical stimulation test (Hilger test) and its statistical correlation to facial palsy evolution after 6 months. Results: Data indicated that patients above 60 years old had worse prognosis in comparison with patients under 30 years old. A progressive mode of paralysis installation, absence of previous symptoms, concomitant vertigo and response superior to 3.5 mA at minimum electrical stimulation test were also related to worse prognosis. On the other hand, the absence of concomitant symptoms, diminished tearing and sudden onset were related to better prognosis. Conclusion: Clinical factors and Hilger’s test can accurately indicate the prognosis in cases of Bell’s palsy when ENoG is not available

Management of peripheral facial nerve palsy

Peripheral facial nerve palsy (FNP) may (secondary FNP) or may not have a detectable cause (Bell’s palsy). Three quarters of peripheral FNP are primary and one quarter secondary. The most prevalent causes of secondary FNP are systemic viral infections, trauma, surgery, diabetes, local infections, tumor, immunological disorders, or drugs. The diagnosis of FNP relies upon the presence of typical symptoms and signs, blood chemical investigations, cerebro-spinal-fluid-investigations, X-ray of the scull and mastoid, cerebral MRI, or nerve conduction studies. Bell’s palsy may be diagnosed after exclusion of all secondary causes, but causes of secondary FNP and Bell’s palsy may coexist. Treatment of secondary FNP is based on the therapy of the underlying disorder. Treatment of Bell’s palsy is controversial due to the lack of large, randomized, controlled, prospective studies. There are indications that steroids or antiviral agents are beneficial but also studies, which show no beneficial effect. Additional measures include eye protection, physiotherapy, acupuncture, botulinum toxin, or possibly surgery. Prognosis of Bell’s palsy is fair with complete recovery in about 80% of the cases, 15% experience some kind of permanent nerve damage and 5% remain with severe sequelae

Cooperative bimanual action

We present an experiment on cooperative bimanual action. Right-handed subjects manipulated a pair of physical objects, a tool and a target object, so that the tool would touch a target on the object @g. 1). For this task, there is a marked specialization of the hands. Performance is best when the left hand orients the target object and the right hand manipulates the tool, but is significantly reduced when these roles are reversed. This suggests that the right hand operates relative to the frame-of-reference of the left hand. Furthermore, when physical constraints guide the tool placement, this fundamentally changes the type of motor control required. The task is tremendously simplified for both hands, and reversing roles of the hands is no longer an important factor. Thus, specialization of the roles of the hands is significant only for skilled manipulation

Preventing a tobacco epidemic in Africa: a call for effective action to support health, social, and economic development

Report of the Committee on the Negative Effects of Tobacco on Africa's Health, Economy and DevelopmentIn April 2013, the Network of African Science Academies convened a committee of experts to discuss the evidence, obstacles, and opportunities for implementing and enforcing tobacco use prevention and control policies in Africa. The committee, consisting of 16 experts drawn from 8 countries in Africa, met for 3 days in Kampala, Uganda, with funding administered by the Campaign for Tobacco Free Kids. Each distinguished committee member was selected for his or her in-depth tobacco-specific knowledge in areas including agriculture, policy, economics, social science, health, and the environment. The committee reviewed and assessed the evidence on the state of tobacco use and tobacco production and their detrimental health, economic, and environmental effects in Africa. The committee also reviewed efforts currently under way to prevent and control tobacco use, including the status of adoption and ratification of the World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC). Based on this evidence, the committee reached consensus on actions that African leaders and other stakeholders should take to combat this growing threat. This report presents the committee's evidence-based recommendations for tobacco control in Africa. It outlines strategies that should place tobacco control policy on the African leadership agenda, and also calls upon other groups, such as civil society organizations, to share in the responsibility of protecting those most vulnerable to misleading and deceitful messaging by the tobacco industry

D1.3 Overview of Existing Interoperability of Virtual Factories

The FIRST (vF Interoperation suppoRting buSiness innovation) project aims to provide new technology and methodologies to describe manufacturing assets; to compose and integrate existing services into collaborative virtual manufacturing processes; and to deal with evolution of changes. This deliverable describes the state of the art of existing interoperability of virtual factory Task T1.6 Inventories and assess existing manufacturing interoperate frameworks and analysis requirements and defining use cases for design and validation of the proposed interoperate framework, thus creating a baseline for the research, in relation to working package WP5. Section 1 includes a general introduction of the deliverable. Section 2 reviews interoperability of virtual factory architecture in the context of the RAMI 4.0 architecture, international/industrial data space (IDS), interoperability framework for digital manufacturing platforms, FIWARE smart industry architecture, and sources of further information. Section 3 looks at the issues how to dynamically switch between streaming data sources. Numbers of approaches are reviewed for supporting dynamic on-the-fly switching between streaming data sources for distributed big data analysis and data source interoperability. Multiple manufacturing domains encompass a wide variety of systems where each of them has their own formats, concepts, relationships, data structures, syntaxes and semantics. Section 4 reviews 10 approaches related to different manufacturing aspects of manufacturing assets/services classification for interoperability of virtual factory. Section 5 provides principles of manufacturing services discovery and composition methods for supporting interoperability of digital factory. Section 6 briefly summarized FIWARE platform and describe how FIRST interoperability framework could be built based on FIWARE platform. Section 7 introduces KM software manufacturing solutions and provides data interoperability requirements to FIRST framework. Section 8 includes a case study of Shuangchi shoe manufacturing processes and analyses the current process limitations. The overview of existing interoperability related technologies provides blueprint for our further research on WP5 as well as WP2, WP3, WP4. The initial research in this deliverable is going to be refined in a later release of this deliverable, following the results of WP2, WP3, WP4, and WP