79 research outputs found
Project of a superfluid He3 detector for direct detection of non-baryonic dark matter : MACHe3
MACHe3 (MAtrix of Cells of superfluid Helium 3) is a project of non-baryonic
Dark Matter search using superfluid He3 as sensitive medium. Simulations on a
high granularity matrix show very good rejection against background events.
First results on a prototype cell are very encouraging. Neutron detection has
been highlighted as well as cosmic muon detection. A phenomenological study has
been done with the DarkSUSY code to investigate complementarity of MACHe3 with
existing Dark Matter detectors.Comment: 5 pages, 5 figures, to appear in Proceedings of the 4th Marseille
International Cosmology Conferenc
Ferromagnetism of He Films in the Low Field Limit
We provide evidence for a finite temperature ferromagnetic transition in
2-dimensions as in thin films of He on graphite, a model system
for the study of two-dimensional magnetism. We perform pulsed and CW NMR
experiments at fields of 0.03 - 0.48 mT on He at areal densities of 20.5 -
24.2 atoms/nm. At these densities, the second layer of He has a
strongly ferromagnetic tendency. With decreasing temperature, we find a rapid
onset of magnetization that becomes independent of the applied field at
temperatures in the vicinity of 1 mK. Both the dipolar field and the NMR
linewidth grow rapidly as well, which is consistent with a large (order unity)
polarization of the He spins.Comment: 4 figure
Determination of the mosaic angle distribution of Grafoil platelets using continuous-wave NMR spectra
We described details of a method to estimate with good accuracy the mosaic
angle distributions of microcrystallites (platelets) in exfoliated graphite
like Grafoil which is commonly used as an adsorption substrate for helium thin
films. The method is based on analysis of resonance field shifts in
continuous-wave (CW) NMR spectra of He ferromagnetic monolayers making
use of the large nuclear polarization of the adsorbate itself. The mosaic angle
distribution of a Grafoil substrate analyzed in this way can be well fitted to
a gaussian form with a deg spread. This distribution is quite
different from the previous estimation based on neutron scattering data which
showed an unrealistically large isotropic powder-like component.Comment: 6 pages, 5 figure
Drug-loaded erythrocytes: on the road toward marketing approval.
Erythrocyte drug encapsulation is one of the most promising therapeutic alternative approaches for the administration of toxic or rapidly cleared drugs. Drug-loaded erythrocytes can operate through one of the three main mechanisms of action: extension of circulation half-life (bioreactor), slow drug release, or specific organ targeting. Although the clinical development of erythrocyte carriers is confronted with regulatory and development process challenges, industrial development is expanding. The manufacture of this type of product can be either centralized or bedside based, and different procedures are employed for the encapsulation of therapeutic agents. The major challenges for successful industrialization include production scalability, process validation, and quality control of the released therapeutic agents. Advantages and drawbacks of the different manufacturing processes as well as success key points of clinical development are discussed. Several entrapment technologies based on osmotic methods have been industrialized. Companies have already achieved many of the critical clinical stages, thus providing the opportunity in the future to cover a wide range of diseases for which effective therapies are not currently available
Evidence for a Self-Bound Liquid State and the Commensurate-Incommensurate Coexistence in 2D He on Graphite
We made heat-capacity measurements of two dimensional (2D) He adsorbed on
graphite preplated with monolayer He in a wide temperature range (0.1 80 mK) at densities higher than that for the 4/7 phase (= 6.8
nm). In the density range of 6.8 8.1 nm, the 4/7
phase is stable against additional He atoms up to 20% and they are promoted
into the third layer. We found evidence that such promoted atoms form a
self-bound 2D Fermi liquid with an approximate density of 1 nm from the
measured density dependence of the -coefficient of heat capacity. We
also show evidence for the first-order transition between the commensurate 4/7
phase and the ferromagnetic incommensurate phase in the second layer in the
density range of 8.1 9.5 nm.Comment: 6 pages, 4 figure
Magnetization plateau in a two-dimensional multiple-spin exchange model
We study a multiple-spin exchange model on a triangular lattice, which is a
possible model for low-density solid 3He films. Due to strong competitions
between ferromagnetic three-spin exchange and antiferromagnetic four-spin one,
the ground states are highly degenerate in the classical limit. At least
2^{L/2}-fold degeneracy exists on the L*L triangular lattice except for the
SO(3) symmetry. In the magnetization process, we found a plateau at
m/m_{sat}=1/2, in which the ground state is "uuud state" (a collinear state
with four sublattices). The 1/2-plateau appears due to the strong four-spin
exchange interaction. This plateau survives against both quantum and thermal
fluctuations. Under a magnetic field which realizes the "uuud" ordered state, a
phase transition occurs at a finite temperature. We predict that low-density
solid 3He thin films may show the 1/2-plateau in the magnetization process.
Experimental observation of the plateau will verify strength of the four-spin
exchange. It is also discussed that this magnetization plateau can be
understood as an insulating-conducting transition in a particle picture.Comment: 10 pages, RevTeX, 12 figures, added a reference and corrected typos,
to be published in Phys.Rev.B (01 APR 99
Spin-Wave Theory of the Multiple-Spin Exchange Model on a Triangular Lattice in a Magnetic Field : 3-Sublattice Structures
We study the spin wave in the S=1/2 multiple-spin exchange model on a
triangular lattice in a magnetic field within the linear spin-wave theory. We
take only two-, three- and four-spin exchange interactions into account and
restrict ourselves to the region where a coplanar three-sublattice state is the
mean-field ground state. We found that the Y-shape ground state survives
quantum fluctuations and the phase transition to a phase with a 6-sublattice
structure occurs with softening of the spin wave. We estimated the quantum
corrections to the ground state sublattice magnetizations due to zero-point
spin-wave fluctuations.Comment: 8 pages, 20 figure
Dual Vortex Theory of Strongly Interacting Electrons: Non-Fermi Liquid to the (Hard) Core
As discovered in the quantum Hall effect, a very effective way for
strongly-repulsive electrons to minimize their potential energy is to aquire
non-zero relative angular momentum. We pursue this mechanism for interacting
two-dimensional electrons in zero magnetic field, by employing a representation
of the electrons as composite bosons interacting with a Chern-Simons gauge
field. This enables us to construct a dual description in which the fundamental
constituents are vortices in the auxiliary boson fields. The resulting
formalism embraces a cornucopia of possible phases. Remarkably,
superconductivity is a generic feature, while the Fermi liquid is not --
prompting us to conjecture that such a state may not be possible when the
interactions are sufficiently strong. Many aspects of our earlier discussions
of the nodal liquid and spin-charge separation find surprising incarnations in
this new framework.Comment: Modified dicussion of the hard-core model, correcting several
mistake
Dark matter with invisible light from heavy double charged leptons of almost-commutative geometry?
A new candidate of cold dark matter arises by a novel elementary particle
model: the almostcommutative AC-geometrical framework. Two heavy leptons are
added to the Standard Model, each one sharing a double opposite electric charge
and an own lepton flavor number The novel mathematical theory of
almost-commutative geometry [1] wishes to unify gauge models with gravity. In
this scenario two new heavy (m_L>100GeV), oppositely double charged leptons
(A,C),(A with charge -2 and C with charge +2), are born with no twin quark
companions. The model naturally involves a new U(1) gauge interaction,
possessed only by the AC-leptons and providing a Coulomblike attraction between
them. AC-leptons posses electro-magnetic as well as Z-boson interaction and,
according to the charge chosen for the new U(1) gauge interaction, a new
"invisible light" interaction. Their final cosmic relics are bounded into
"neutral" stable atoms (AC) forming the mysterious cold dark matter, in the
spirit of the Glashow's Sinister model. An (AC) state is reached in the early
Universe along a tail of a few secondary frozen exotic components. They should
be now here somehow hidden in the surrounding matter. The two main secondary
manifest relics are C (mostly hidden in a neutral (Cee) "anomalous helium"
atom, at a 10-8 ratio) and a corresponding "ion" A bounded with an ordinary
helium ion (4He); indeed the positive helium ions are able to attract and
capture the free A fixing them into a neutral relic cage that has nuclear
interaction (4HeA).Comment: This paper has been merged with [astro-ph/0603187] for publication in
Classical and Quantum Gravit
The relationship between doses of mindfulness-based programs and depression, anxiety, stress, and mindfulness: a dose-response meta-regression of randomized controlled trials
Abstract
Objectives: Research with mindfulness-based programs (MBPs) has found participating in an MBP to predict beneficial outcomes, however, there is currently mixed research regarding the most helpful dose. This review aimed to determine whether different doses related to MBPs significantly predict outcomes.
Methods: Systematic literature searches of electronic databases and trial registration sites for all randomized controlled trials of MBPs identified 203 studies (N=15,971). Depression was the primary outcome at post-program and follow-up, with secondary outcomes being mindfulness, anxiety and stress. Doses examined related to session numbers, duration and length, facilitator contact and practice. Dose-response relationships were analyzed using meta-regression in R with separate analyses for inactive and active controls.
Results: Initial meta-analyses found significant between-group differences favoring MBPs for all outcomes. Meta-regression results suggested significant dose-response relationships for the mindfulness outcome for doses relating to face-to-face contact (d=0.211; C.I.[0.064,0.358]), program intensity (d=0.895; C.I.[0.315,1.474]) and actual program use (d=0.013; C.I.[0.001,0.024]). The majority of results for psychological outcomes, including depression, were not significant.
Conclusions:
This meta-regression examines dose-response relationships for different types and doses relating to MBPs. Considered together, MBPs appeared helpful compared to controls, supporting previous research. Based on meta-regression results, there was no evidence that larger doses are more helpful than smaller doses for predicting psychological outcomes; a finding consistent with some previous research particularly with non-clinical populations. Additionally, greater contact, intensity and actual use of MBPs predicting increased mindfulness corresponds with previous research and theory. Potential limitations and recommendations for future research are explored
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