La mujer de Palencia

Hojas sueltas de: Las mujeres españolas, portuguesas y americanas..., t.II.Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

Discursos pronunciados en defensa del Excmo. señor D. Agustín Esteban Collantes, ante el Congreso de los Diputados y ante el Senado ... con motivo de la acusación formulada contra él ... en el expediente sobre acopio de 130.000 cargos de piedra

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Contiene: Discursos pronunciados por ... Agustín Esteban Collantes. Discurso pronunciado ... por Juan González Acevedo. Discurso pronunciado ... por Manuel Cortin

La devoción a las ánimas del purgatorio en Cádiz: dos hermandades para su estudio

A partir de los ataques de Lutero contra la idea del purgatorio, España mantuvo con intensidad la defensa de su existencia con multitud de tratados y expresiones cultuales. Cádiz no fue una excepción en el desarrollo del culto a las ánimas del purgatorio, con diferentes hermandades nacidas para mantenerlo. Entre todas ellas destacan las elegidas para este artículo: la Esclavitud del Santísimo Sacramento y archicofradía de las Benditas Ánimas, y la Hermandad de San Nicolás de Tolentino localizada en el convento de San Agustín, cuyo estudio se acomete a continuación.

Informe que la Real Academia de Ciencias Morales y Políticas eleva al Gobierno sobre los Foros de Galicia, Asturias y León

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Separata de: Memorias de la Real A. de C. Morales y Políticas. Tomo I

Discurso que el Señor D. Mariano Collantes y Bustamante, regente de la Audiencia Territorial de Burgos, pronunció en la solemne apertura de la misma el dia 2 de enero de 1844.

Del texto se deduce impreso ca. 1844

Superconductivity in Undoped BaFe2As2 by Tetrahedral Geometry Design

Fe-based superconductors exhibit a diverse interplay between charge, orbital, and magnetic ordering1-4. Variations in atomic geometry affect electron hopping between Fe atoms5,6 and the Fermi surface topology, influencing magnetic frustration and the pairing mechanism through changes of orbital overlap and occupancies7-11. Here, we experimentally demonstrate a systematic approach to realize superconductivity without chemical doping in BaFe2As2, employing geometric design within an epitaxial heterostructure. We control both tetragonality and orthorhombicity in BaFe2As2 through superlattice engineering, which we experimentally find to induce superconductivity when the As-Fe-As bond angle approaches that in a regular tetrahedron. This approach of superlattice design could lead to insights into low dimensional superconductivity in Fe-based superconductors

Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model

<p>Abstract</p> <p>Background</p> <p>There is strong evidence demonstrating that activation of epidermal growth factor receptors (EGFRs) leads to tumor growth, progression, invasion and metastasis. Erlotinib and gefitinib, two EGFR-targeted agents, have been shown to be relevant drugs for lung cancer treatment. Recent studies demonstrate that lapatinib, a dual tyrosine kinase inhibitor of EGFR and HER-2 receptors, is clinically effective against HER-2-overexpressing metastatic breast cancer. In this report, we investigated the activity of lapatinib against non-small cell lung cancer (NSCLC).</p> <p>Methods</p> <p>We selected the lung cancer cell line A549, which harbors genomic amplification of EGFR and HER-2. Proliferation, cell cycle analysis, clonogenic assays, and signaling cascade analyses (by western blot) were performed <it>in vitro</it>. <it>In vivo </it>experiments with A549 cells xenotransplanted into nude mice treated with lapatinib (with or without radiotherapy) were also carried out.</p> <p>Results</p> <p>Lapatinib dramatically reduced cell proliferation (<it>P </it>< 0.0001), DNA synthesis (<it>P </it>< 0.006), and colony formation capacity (<it>P </it>< 0.0001) in A549 cells <it>in vitro</it>. Furthermore, lapatinib induced G1 cell cycle arrest (<it>P </it>< 0.0001) and apoptotic cell death (<it>P </it>< 0.0006) and reduced cyclin A and B1 levels, which are regulators of S and G2/M cell cycle stages, respectively. Stimulation of apoptosis in lapatinib-treated A549 cells was correlated with increased cleaved PARP, active caspase-3, and proapoptotic Bak-1 levels, and reduction in the antiapoptic IAP-2 and Bcl-xL protein levels. We also demonstrate that lapatinib altered EGFR/HER-2 signaling pathways reducing p-EGFR, p-HER-2, p-ERK1/2, p-AKT, c-Myc and PCNA levels. <it>In vivo </it>experiments revealed that A549 tumor-bearing mice treated with lapatinib had significantly less active tumors (as assessed by PET analysis) (<it>P </it>< 0.04) and smaller in size than controls. In addition, tumors from lapatinib-treated mice showed a dramatic reduction in angiogenesis (<it>P </it>< 0.0001).</p> <p>Conclusion</p> <p>Overall, these data suggest that lapatinib may be a clinically useful agent for the treatment of lung cancer.</p