Kafeinin rat karaciğer ve kalp dokusunda oksidan stres üzerine etkisi

Amaç: Biz bu çalışmada kafeinin rat karaciğer ve kalp dokusunda malondialdehit (MDA), nitrik oksit (NO) ve gelişmiş okside protein ürünleri (AOPP) düzeylerine etkisini araştırdık. Yöntem ve gereç: Çalışmaya 30 rat dahil edilmiştir. Ratlar eşit 3 gruba ayrılmıştır, kontrol grubu ve 2 kafeinli grup. Grup 1’e 30 mg/kg kafein, grup 2’ye 100 mg/kg kafein 14 gün boyunca verilmiştir. Bulgular: MDA ve AOPP düzeyleri karaciğerde kafeinli gruplarda dozla ilişkili olarak anlamlı azalmalar göstermiştir. Kalp dokusunda MDA ve AOPP düzeyleri kafeinle azalmıştır ancak bu etki dozdan bağımsızdır. NO düzeyleri karaciğerde kafeinli gruplarda kontrol grubuna göre artmıştır ancak kalp dokusunda kafeinin NO düzeylerine etkisi önemsizdir. Sonuç: Bu sonuçlar göstermiştir ki kısa süreli kafein alımı karaciğer dokusunda oksidatif stresten koruyucu etki göstermektedir. Bu etkiler karaciğerde doz ile ilişkilidir. Kafeinin etki mekanizmalarının bilinmesi için daha ileri çalışmalara ihtiyaç vardır.Aim: To investigate the effect of caffeine on the levels of malondialdehyde (MDA), nitric oxide (NO), and advanced oxidation protein products (AOPP) in the liver and heart tissues of rats. Materials and methods: The current study included 30 rats, which were divided into 3 groups: a control group and 2 caffeine-treated groups. Group 1 was given caff eine at 30 mg/kg and Group 2 was given caff eine at 100 mg/kg (a high nontoxic dose) for 14 days. Results: MDA and AOPP levels in the liver tissue of the caffeine-treated groups decreased significantly as a result of the dose. MDA and AOPP levels in the heart tissue also decreased, but this eff ect was not significantly affected by the dose. NO levels in the liver tissue of the caffeine-treated groups were higher than those in the control group; in the heart tissues, however, NO levels were not significantly aff ected by caffeine. Conclusion: Th ese results show that the short-term consumption of 2 different doses of caffeine may potentially protect against oxidative stress in the liver. Th is eff ect is related to the dose of caffeine in the liver tissue. Further studies will be needed to discover the mechanisms responsible for these findings

Increased serum YKL-40 level is associated with the presence and severity of metabolic syndrome.

Metabolic syndrome (MS) is defined by a cluster of interdependent physiological, biochemical, and clinical risk factors and linked to a state of chronic inflammation. YKL-40 is known as an inflammatory glycoprotein, which is secreted by various cell lines during inflammation. Thus, we aimed to assess the association of serum YKL-40 levels with the presence and severity of MS

Do vitamin D and high-sensitivity-C reactive protein levels differ in patients with hyperemesis gravidarum? A preliminary study.

The high sensitivity-C reactive protein (hs-CRP) is an inflammatory marker and vitamin D is an immune modulator that might play a critical role in the pathogenesis of hyperemesis gravidarum. Therefore, in the current study, we tested the hypothesis that suggests women with hyperemesis gravidarum have lower 25-hydroxyvitamin D levels and higher hs-CRP levels, compared to controls

Serum Total Sialic Acid Level is Elevated in Hypothyroid Patients as an Atherosclerotic Risk Factor.

Serum total sialic acid (TSA) concentration is regarded as an indicator of the risks of atherosclerosis and cardiovascular diseases. The association between SA levels and atherosclerosis risk factors has not been assessed in patients with thyroid diseases