15 research outputs found
Determination of catalytic effects od Pd and Pd based electrodes in electrooxidation of glycerol
Tez (Doktora)--İTÜ Fen Bil. Enst., 1993Thesis (Ph.D.) -- İstanbul Technical University, Institute of Science and Technology, 1993DoktoraPh.D
Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode
Electrochemical reduction and determination of montelukast (MKS) was studied in methanol – 0.1 M HCl solution (1 :1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70107–1.83105 M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32108 M and 1.61107 M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique
Investigation of Curcumin Water Solubility Through Emulsifying with Biocompatible Polyethylene Glycol-Based Polymers
The low water solubility of curcumin prevents various biological and pharmacological activities, which prevent adequate bioavailability. Herein, two new emulsifier systems have been developed and optimized to increase the water solubility of curcumin. The first emulsion system containing curcumin was prepared using polyethylene glycol monooleate-460 (PEG-oleate) for the oily phase, Tween 20 as the emulsifier, and acetic acid as stabilizing agent. In this emulsion system, Box-Behnken experiment design was applied to find the most favorable conditions and substance ratios. Transmission electron microscopy (TEM) analysis was performed for the emulsion system obtained under optimum conditions. For this emulsion system, the curcumin solubility was found to be 709 times higher than the solubility of raw curcumin. The second emulsion systems developed was carried out using our newly synthesized methoxy polyethylene glycol monooleate-550 (methoxy PEG-oleate). The best curcumin solubility was obtained when the ratio of curcumin-methoxy PEG-oleate was 1:5 (w/w). The solubility of curcumin in this system was 56 times higher than that of raw curcumin. Interactions were characterized by FTIR measurements. Solubility, encapsulation capacity, dissolution, and stability studies were performed. The amount of curcumin in the emulsion systems was carried out by newly developed reversed phase high-performance liquid chromatography