204 research outputs found
Salvianolic acid B promotes bone formation by increasing activity of alkaline phosphatase in a rat tibia fracture model: a pilot study
Ref-NPR: Reference-Based Non-Photorealistic Radiance Fields for Controllable Scene Stylization
Current 3D scene stylization methods transfer textures and colors as styles
using arbitrary style references, lacking meaningful semantic correspondences.
We introduce Reference-Based Non-Photorealistic Radiance Fields (Ref-NPR) to
address this limitation. This controllable method stylizes a 3D scene using
radiance fields with a single stylized 2D view as a reference. We propose a ray
registration process based on the stylized reference view to obtain pseudo-ray
supervision in novel views. Then we exploit semantic correspondences in content
images to fill occluded regions with perceptually similar styles, resulting in
non-photorealistic and continuous novel view sequences. Our experimental
results demonstrate that Ref-NPR outperforms existing scene and video
stylization methods regarding visual quality and semantic correspondence. The
code and data are publicly available on the project page at
https://ref-npr.github.io.Comment: Accepted by CVPR2023. 17 pages, 20 figures. Project page:
https://ref-npr.github.io, Code: https://github.com/dvlab-research/Ref-NP
Topological Insulators-Based Magnetic Heterostructure
The combination of magnetism and topology in magnetic topological insulators
(MTIs) has led to unprecedented advancements of time reversal symmetry-breaking
topological quantum physics in the past decade. Compared with the uniform
films, the MTI heterostructures provide a better framework to manipulate the
spin-orbit coupling and spin properties. In this review, we summarize the
fundamental mechanisms related to the physical orders host in
(Bi,Sb)2(Te,Se)3-based hybrid systems. Besides, we provide an assessment on the
general strategies to enhance the magnetic coupling and spin-orbit torque
strength through different structural engineering approaches and effective
interfacial interactions. Finally, we offer an outlook of MTI
heterostructures-based spintronics applications, particularly in view of their
feasibility to achieve room-temperature operation.Comment: 33 pages, 11 figure
ChatEDA: A Large Language Model Powered Autonomous Agent for EDA
The integration of a complex set of Electronic Design Automation (EDA) tools
to enhance interoperability is a critical concern for circuit designers. Recent
advancements in large language models (LLMs) have showcased their exceptional
capabilities in natural language processing and comprehension, offering a novel
approach to interfacing with EDA tools. This research paper introduces ChatEDA,
an autonomous agent for EDA empowered by a large language model, AutoMage,
complemented by EDA tools serving as executors. ChatEDA streamlines the design
flow from the Register-Transfer Level (RTL) to the Graphic Data System Version
II (GDSII) by effectively managing task planning, script generation, and task
execution. Through comprehensive experimental evaluations, ChatEDA has
demonstrated its proficiency in handling diverse requirements, and our
fine-tuned AutoMage model has exhibited superior performance compared to GPT-4
and other similar LLMs
MicroRNA-96 Promotes Schistosomiasis Hepatic Fibrosis in Mice by Suppressing Smad7
Infection with Schistosoma causes aberrant expression of host microRNAs (miRNAs), and normalizing the levels of dysregulated miRNAs can attenuate pathology. Here, we show that the host miRNA, miR-96, is markedly upregulated during the progression of hepatic schistosomiasis. We demonstrate that elevation of miR-96 induces hepatic fibrosis in infected mice by suppressing the expression of its target gene, Smad7. We show that infection with Schistosoma induces the expression of transforming growth factor beta1 (TGF-beta1), which in turn upregulates the expression of miR-96 through SMAD2/3-DROSHA-mediated post-transcriptional regulation. Furthermore, inhibition of miR-96 with recombinant adeno-associated virus 8 (rAAV8)-mediated delivery of Tough Decoy RNAs in mice attenuated hepatic fibrosis and prevented lethality following schistosome infection. Taken together, our data highlight the potential for rAAV8-mediated inhibition of miR-96 as a therapeutic strategy to treat hepatic schistosomiasis
Evaluation of Anti-Inflammatory Activities of Qingre-Qushi Recipe (QRQS) against Atopic Dermatitis: Potential Mechanism of Inhibition of IL-33/ST2 Signal Transduction
To evaluate the anti-inflammatory activities of QRQS against AD and the inhibitory molecular mechanisms of IL-33/ST2 signal transduction, BALB/c mice were divided into six groups (normal control, OVA control, low-dose of QRQS, middle-dose of QRQS, high-dose of QRQS, and cetirizine) and epicutaneously exposed to ovalbumin or PBS for 3 weeks and treated with QRQS for 2 weeks. Skin biopsies and blood samples were obtained for histological study, antibody analysis, and RNA isolation. HaCaT cells, stimulated by TNF-α and IFN-γ, were treated with QRQS to evaluate mRNA and protein expression by RT-PCR and ELISA. QRQS decreased both epidermal and dermal thickness, alleviated dermatitis, and reduced IL-33 and ST2 positive cell numbers. The concentration of specific IgE, IgG, IgG1, and IgG2a antibodies in serum and the expression of IL-33, ST2, IL-1RAcP, IL-4, and IL-13 mRNA in the skin were suppressed. No significant difference exists in TNF-α or IFN-γ. QRQS decreased IL-33 mRNA and protein secretion in HaCaT cells exposed to TNF-α and IFN-γ in a time- and concentration-dependent manner. QRQS regulates related molecule expression of ovalbumin-induced dermatitis involved in the IL-33/ST2 signaling axis in the treatment of acute AD
Examining the Dynamic Association of BMI and Mortality in the Framingham Heart Study
Based on the 40-year follow-up of the Framingham Heart Study (FHS), we used logistic regression models to demonstrate that different designs of an observational study may lead to different results about the association between BMI and all-cause mortality. We also used dynamic survival models to capture the time-varying relationships between BMI and mortality in FHS. The results consistently show that the association between BMI and mortality is dynamic, especially for men. Our analysis suggests that the dynamic property may explain part of the heterogeneity observed in the literature about the association of BMI and mortality
- …