Numerical Simulation of Hot Accretion Flows (III): Revisiting wind properties using trajectory approach

Previous MHD simulations have shown that wind must exist in black hole hot accretion flows. In this paper, we continue our study by investigating the detailed properties of wind, such as mass flux and poloidal speed, and the mechanism of wind production. For this aim, we make use of a three dimensional GRMHD simulation of hot accretion flows around a Schwarzschild black hole. The simulation is designed so that the magnetic flux is not accumulated significantly around the black hole. To distinguish real wind from turbulent outflows, we track the trajectories of the virtual Largrangian particles from simulation data. We find two types of real outflows, i.e., a quasi-relativistic jet close to the axis and a sub-relativistic wind subtending a much larger solid angle. Most of the wind originates from the surface layer of the accretion flow. The poloidal wind speed almost remains constant once they are produced, but the flux-weighted wind speed roughly follows $v_{\rm p, wind}(r)\approx 0.25 v_k(r)$. The mass flux of jet is much lower but the speed is much higher, $v_{\rm p,jet}\sim (0.3-0.4) c$. Consequently, both the energy and momentum fluxes of the wind are much larger than those of the jet. We find that the wind is produced and accelerated primarily by the combination of centrifugal force and magnetic pressure gradient, while the jet is mainly accelerated by magnetic pressure gradient. Finally, we find that the wind production efficiency $\epsilon_{\rm wind}\equiv\dot{E}_{\rm wind}/\dot{M}_{\rm BH}c^2\sim 1/1000$, in good agreement with the value required from large-scale galaxy simulations with AGN feedback.Comment: 13 pages, 13 figures; submitted to Ap

Klein-Nishina effects on the high-energy afterglow emission of gamma-ray bursts

Extended high-energy(>100MeV) gamma-ray emission that lasts much longer than the prompt sub-MeV emission has been detected from quite a few gamma-ray bursts (GRBs) by Fermi Large Area Telescope (LAT) recently. A plausible scenario is that this emission is the afterglow synchrotron emission produced by electrons accelerated in the forward shocks. In this scenario, the electrons that produce synchrotron high-energy emission also undergo inverse-Compton (IC) loss and the IC scattering with the synchrotron photons should be in the Klein-Nishina regime. Here we study effects of the Klein-Nishina scattering on the high-energy synchrotron afterglow emission. We find that, at early times the Klein-Nishina suppression effect on those electrons that produce the high-energy emission is usually strong and therefore their inverse-Compton loss is small with a Compton parameter Y < a few for a wide range of parameter space. This leads to a relatively bright synchrotron afterglow at high energies that can be detected by Fermi LAT. As the Klein-Nishina suppression effect weakens with time, the inverse-Compton loss increases and could dominate over the synchrotron loss in some parameter space. This will lead to a faster temporal decay of the high-energy synchrotron emission than what is predicted by the standard synchrotron model, which may explain the observed rapid decay of the early high-energy gamma-ray emission in GRB090510 and GRB090902B.Comment: 8 page (emulateapj style), 8 figures, submitted to Ap

Optimal fuzzy iterative learning control based on artificial bee colony for vibration control of piezoelectric smart structures

Combining P-type iterative learning (IL) control, fuzzy logic control and artificial bee colony (ABC) algorithm, a new optimal fuzzy IL controller is designed for active vibration control of piezoelectric smart structures. In order to accelerate the learning speed of feedback gain, the fuzzy logic controller is integrated into the ANSYS finite element (FE) models by using APDL (ANSYS Parameter Design Language) approach to adjust adaptively the learning gain of P-type IL control. For improving the performance and robustness of the fuzzy logic controller as well as diminishing human intervention in the operation process, ABC algorithm is used to automatically identify the optimal configurations for values in fuzzy query table, fuzzification parameters and defuzzification parameters, and the main program of ABC algorithm is operated in MATLAB. The active vibration equations are driven from the FE equations for the dynamic response of a linear elastic piezoelectric smart structure. Considering the vibrations generated by various external disturbances, the optimal fuzzy IL controller is numerically investigated for a clamped piezoelectric smart plate. Results demonstrate that the proposed control approach makes the feedback gain has a fast learning speed and performs excellent in vibration suppression. This is demonstrated in the results by comparing the new control approach with the P-type IL control

Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study

Tuberculosis (TB) is still a major public health issue in developing countries, and its chemotherapy is compromised by poor drug compliance and severe side effects. This study aimed to synthesize and characterize new multimodal PEGylated liposomes encapsulated with clinically commonly used anti-TB drugs with linkage to small interfering RNA (siRNA) against transforming growth factor-&beta;1 (TGF-&beta;1). The novel NP-siRNA liposomes could target THP-1-derived human macrophages that were the host cells of mycobacterium infection. The biological effects of the NP-siRNA liposomes were evaluated on cell cycle distribution, apoptosis, autophagy, and the gene silencing efficiency of TGF-&beta;1 siRNA in human macrophages. We also explored the proteomic responses to the newly synthesized NP-siRNA liposomes using the stable isotope labeling with amino acids in cell culture approach. The results showed that the multifunctional PEGylated liposomes were successfully synthesized and chemically characterized with a mean size of 265.1 nm. The novel NP-siRNA liposomes functionalized with the anti-TB drugs and TGF-&beta;1 siRNA were endocytosed efficiently by human macrophages as visualized by transmission electron microscopy and scanning electron microscopy. Furthermore, the liposomes showed a low cytotoxicity toward human macrophages. There was no significant effect on cell cycle distribution and apoptosis in THP-1-derived macrophages after drug exposure at concentrations ranging from 2.5 to 62.5 &mu;g/mL. Notably, there was a 6.4-fold increase in the autophagy of human macrophages when treated with the NP-siRNA liposomes at 62.5 &mu;g/mL. In addition, the TGF-&beta;1 and nuclear factor-&kappa;B expression levels were downregulated by the NP-siRNA liposomes in THP-1-derived macrophages. The Ingenuity Pathway Analysis data showed that there were over 40 signaling pathways involved in the proteomic responses to NP-siRNA liposome exposure in human macrophages, with 160 proteins mapped. The top five canonical signaling pathways were eukaryotic initiation factor 2 signaling, actin cytoskeleton signaling, remodeling of epithelial adherens junctions, epithelial adherens junction signaling, and Rho GDP-dissociation inhibitor signaling pathways. Collectively, the novel synthetic targeting liposomes represent a promising delivery system for anti-TB drugs to human macrophages with good selectivity and minimal cytotoxicity

On the High Energy Emission of the Short GRB 090510

Long-lived high-energy (>100MeV) emission, a common feature of most Fermi-LAT detected gamma-ray burst, is detected up to \sim 10^2 s in the short GRB 090510. We study the origin of this long-lived high-energy emission, using broad-band observations including X-ray and optical data. We confirm that the late > 100 MeV, X-ray and optical emission can be naturally explained via synchrotron emission from an adiabatic forward shock propagating into a homogeneous ambient medium with low number density. The Klein-Nishina effects are found to be significant, and effects due to jet spreading and magnetic field amplification in the shock appear to be required. Under the constraints from the low-energy observations, the adiabatic forward shock synchrotron emission is consistent with the later-time (t>2s) high-energy emission, but falls below the early-time (t < 2s) high energy emission. Thus we argue that an extra high energy component is needed at early times. A standard reverse shock origin is found to be inconsistent with this extra component. Therefore, we attribute the early part of the high-energy emission (t< 2s) to the prompt component, and the long-lived high energy emission (t>2s) to the adiabatic forward shock synchrotron afterglow radiation. This avoids the requirement for an extremely high initial Lorentz factor.Comment: 29 pages, 2 figures; Accepted for publication in Ap

COVID-19 causes record decline in global CO2 emissions

The considerable cessation of human activities during the COVID-19 pandemic has affected global energy use and CO2 emissions. Here we show the unprecedented decrease in global fossil CO2 emissions from January to April 2020 was of 7.8% (938 Mt CO2 with a +6.8% of 2-{\sigma} uncertainty) when compared with the period last year. In addition other emerging estimates of COVID impacts based on monthly energy supply or estimated parameters, this study contributes to another step that constructed the near-real-time daily CO2 emission inventories based on activity from power generation (for 29 countries), industry (for 73 countries), road transportation (for 406 cities), aviation and maritime transportation and commercial and residential sectors emissions (for 206 countries). The estimates distinguished the decline of CO2 due to COVID-19 from the daily, weekly and seasonal variations as well as the holiday events. The COVID-related decreases in CO2 emissions in road transportation (340.4 Mt CO2, -15.5%), power (292.5 Mt CO2, -6.4% compared to 2019), industry (136.2 Mt CO2, -4.4%), aviation (92.8 Mt CO2, -28.9%), residential (43.4 Mt CO2, -2.7%), and international shipping (35.9Mt CO2, -15%). Regionally, decreases in China were the largest and earliest (234.5 Mt CO2,-6.9%), followed by Europe (EU-27 & UK) (138.3 Mt CO2, -12.0%) and the U.S. (162.4 Mt CO2, -9.5%). The declines of CO2 are consistent with regional nitrogen oxides concentrations observed by satellites and ground-based networks, but the calculated signal of emissions decreases (about 1Gt CO2) will have little impacts (less than 0.13ppm by April 30, 2020) on the overserved global CO2 concertation. However, with observed fast CO2 recovery in China and partial re-opening globally, our findings suggest the longer-term effects on CO2 emissions are unknown and should be carefully monitored using multiple measures

MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma.

Therapeutic applications of microRNAs (miRNAs) in RAS-driven glioma were valuable, but their specific roles and functions have yet to be fully elucidated. Here, we firstly report that miR-143 directly targets the neuroblastoma RAS viral oncogene homolog (N-RAS) and functions as a tumor-suppressor in glioma. Overexpression of miR-143 decreased the expression of N-RAS, inhibited PI3K/AKT, MAPK/ERK signaling, and attenuated the accumulation of p65 in nucleus of glioma cells. In human clinical specimens, miR-143 was downregulated where an adverse with N-RAS expression was observed. Furthermore, overexpression of miR-143 decreased glioma cell migration, invasion, tube formation and slowed tumor growth and angiogenesis in a manner associated with N-RAS downregulation in vitro and in vivo. Finally, miR-143 also sensitizes glioma cells to temozolomide (TMZ),the first-line drug for glioma treatment. Taken together, for the first time, our results demonstrate that miR-143 plays a significant role in inactivating the RAS signaling pathway through the inhibition of N-RAS, which may provide a novel therapeutic strategy for treatment of glioma and other RAS-driven cancers

Climate warming accelerates temporal scaling of grassland soil microbial biodiversity.

Determining the temporal scaling of biodiversity, typically described as species-time relationships (STRs), in the face of global climate change is a central issue in ecology because it is fundamental to biodiversity preservation and ecosystem management. However, whether and how climate change affects microbial STRs remains unclear, mainly due to the scarcity of long-term experimental data. Here, we examine the STRs and phylogenetic-time relationships (PTRs) of soil bacteria and fungi in a long-term multifactorial global change experiment with warming (+3 °C), half precipitation (-50%), double precipitation (+100%) and clipping (annual plant biomass removal). Soil bacteria and fungi all exhibited strong STRs and PTRs across the 12 experimental conditions. Strikingly, warming accelerated the bacterial and fungal STR and PTR exponents (that is, the w values), yielding significantly (P &lt; 0.001) higher temporal scaling rates. While the STRs and PTRs were significantly shifted by altered precipitation, clipping and their combinations, warming played the predominant role. In addition, comparison with the previous literature revealed that soil bacteria and fungi had considerably higher overall temporal scaling rates (w = 0.39-0.64) than those of plants and animals (w = 0.21-0.38). Our results on warming-enhanced temporal scaling of microbial biodiversity suggest that the strategies of soil biodiversity preservation and ecosystem management may need to be adjusted in a warmer world

Aqua­(2,2′-bipyridine-κ2 N,N′)[2-(3-thien­yl)malonato-κ2 O,O′]zinc(II) dihydrate

In the crystal structure of the title compound, [Zn(C7H4O4S)(C10H8N2)(H2O)]·2H2O, the ZnII ion assumes a trigonal–bipyramidal coordination geometry completed by two N atoms from a 2,2′-bipyridine ligand, two O atoms from a 2-(3-thien­yl)malonate anion and a water mol­ecule. The S atom of the 2-(3-thien­yl)malonate ligand is disordered over two sites with an occupancy ratio of 0.701 (5):0.299 (5). Inter­molecular O—H⋯O hydrogen bonding is present in the crystal structure