Three new species of the Phaonia acerba group (Diptera: Muscidae) from Palaearctic and Oriental Regions

Three new species of the Phaonia acerba group fromthe Palaearctic and Oriental Regions are described: P. gaoligongshanensis Xue & Yu, sp. n., P. zhangxianggi Xue & Yu, sp. n. and P. hongkuii Xue & Yu, sp. n. An identification key to the males of 8 species of the Phaonia acerba group from the Palaearctic and Oriental Regions is provided

Activation of TLR4-Mediated NFκB Signaling in Hemorrhagic Brain in Rats

Inflammation and immunity play a crucial role in the pathogenesis of Intracerebral hemorrhage (ICH). Toll-like receptor 4- (TLR4-) mediated nuclear factor kappa-B (NFκB) signaling plays critical roles in the activation and regulation of inflammatory responses in injured brain. However, the involvement of TLR4-mediated NFκB signaling in the pathogenesis of ICH remains unknown. The present study was to evaluate the temporal profile of the expression of TLR4 and the activation of TLR4-mediated NFκB signaling in brain tissues of Wistar rats after ICH. TLR4 mRNA and protein, the phosphorylation of inhibitors of kappa B (p-IκBα), and the activity of NFκB were examined in hemorrhagic cerebral tissue by Rt-PCR, Western blots, immunohistochemistry staining, and EMSA. Compared with saline control, the TLR4 mRNA and protein significantly increased starting at 6 hours after ICH, peaked on the 3rd day after ICH, and then decreased but still maintained at a higher level on the 7th day after ICH (P < .05). The level of p-IκBα and the activity of NFκB also increased in the brain after ICH compared with saline control. The present study firstly suggests that TLR4-mediated NFκB signaling participates in the pathogenesis of ICH, which may become a therapeutic target for ICH-induced brain damage

Demonstration-guided Optimal Control for Long-term Non-prehensile Planar Manipulation

Long-term non-prehensile planar manipulation is a challenging task for robot planning and feedback control. It is characterized by underactuation, hybrid control, and contact uncertainty. One main difficulty is to determine contact points and directions, which involves joint logic and geometrical reasoning in the modes of the dynamics model. To tackle this issue, we propose a demonstration-guided hierarchical optimization framework to achieve offline task and motion planning (TAMP). Our work extends the formulation of the dynamics model of the pusher-slider system to include separation mode with face switching cases, and solves a warm-started TAMP problem by exploiting human demonstrations. We show that our approach can cope well with the local minima problems currently present in the state-of-the-art solvers and determine a valid solution to the task. We validate our results in simulation and demonstrate its applicability on a pusher-slider system with real Franka Emika robot in the presence of external disturbances

Gentiana macrophylla Pall (Gentianaceae) extract exerts protective effects against osteoporosis in mice

Purpose: To evaluate the anti-osteoporotic effect of G. macrophylla extract in a mice model.Methods: Antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) for radical scavenging, nitro-blue tetrazolium (NBT) reducing, and ferric reducing antioxidant power (FRAP) assays using standard biochemical procedures. The expression of some bone-related genes was measured by quantitative real-time polymerase chain reaction (qTR-PCR).  Phytochemical analysis was carried out by liquid chromatography-mass spectrometry (LC/MS).Results: The extract exhibited strong antioxidant activity as evident from DPPH, NBT and FRAP data, with half-maximal inhibitory concentration (IC50) values of 275, 262 and 180 μg/ml, respectively. The antioxidant activity was concentration-dependent. The results showed that the extract restored bone characteristics by suppressing bone resorption through induction of expressions of several boneassociated genes. The results from phytochemical analyses showed the presence of loganic acid, swertiamarin, sweroside, gentiopicroside, gentesin and isogentesin.Conclusion: These results indicate that the extract may be beneficial in the treatment of osteoporosis.Keywords: Gentiana macrophylla, Osteoporosis, Bone mass, Loganic acid, Swertiamarin, Sweroside, Gentiopicroside, Gentesi