Epidemiology of facial fractures: Incidence, prevalence and years lived with disability estimates from the Global Burden of Disease 2017 study

Background: The Global Burden of Disease Study (GBD) has historically produced estimates of causes of injury such as falls but not the resulting types of injuries that occur. The objective of this study was to estimate the global incidence, prevalence and years lived with disability (YLDs) due to facial fractures and to estimate the leading injurious causes of facial fracture. Methods: We obtained results from GBD 2017. First, the study estimated the incidence from each injury cause (eg, falls), and then the proportion of each cause that would result in facial fracture being the most disabling injury. Incidence, prevalence and YLDs of facial fractures are then calculated across causes. Results: Globally, in 2017, there were 7 538 663 (95% uncertainty interval 6 116 489 to 9 4

Global trends of hand and wrist trauma: A systematic analysis of fracture and digit amputation using the Global Burden of Disease 2017 Study

Background: As global rates of mortality decrease, rates of non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this global pattern of non-fatal injury would be demonstrated in regard to bony hand and wrist trauma over the 27-year study period. Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 was used to estimate prevalence, age-standardised incidence and years lived with disability for hand trauma in 195 countries from 1990 to 2017. Individual injuries included hand and wrist fractures, thumb amputations and non-thumb digit amputations. Results: The global incidence of hand trauma has only modestly decreased since 1990. In 2017, t

The Immune Landscape of Cancer

We performed an extensive immunogenomic anal-ysis of more than 10,000 tumors comprising 33diverse cancer types by utilizing data compiled byTCGA. Across cancer types, we identified six im-mune subtypes\u2014wound healing, IFN-gdominant,inflammatory, lymphocyte depleted, immunologi-cally quiet, and TGF-bdominant\u2014characterized bydifferences in macrophage or lymphocyte signa-tures, Th1:Th2 cell ratio, extent of intratumoral het-erogeneity, aneuploidy, extent of neoantigen load,overall cell proliferation, expression of immunomod-ulatory genes, and prognosis. Specific drivermutations correlated with lower (CTNNB1,NRAS,orIDH1) or higher (BRAF,TP53,orCASP8) leukocytelevels across all cancers. Multiple control modalitiesof the intracellular and extracellular networks (tran-scription, microRNAs, copy number, and epigeneticprocesses) were involved in tumor-immune cell inter-actions, both across and within immune subtypes.Our immunogenomics pipeline to characterize theseheterogeneous tumors and the resulting data areintended to serve as a resource for future targetedstudies to further advance the field

RRS James Clark Ross Cruise JR298: Marine geology and geophysics. Antarctic Peninsula Pacific Margin and southern Bellingshausen Sea. January - March 2015

The main purpose of cruise JR298 was to collect marine geological and geophysical samples and data to support International Ocean Discovery Program (IODP) proposal 732- Full2, “Sediment drifts off the Antarctic Peninsula and West Antarctica” (Channell, Larter, Hillenbrand et al.). The ship time was allocated for this purpose on the basis of a Site Survey Investigation grant from the NERC UK-IODP Programme (NE/J006548/1: Depositional patterns and records in sediment drifts off the Antarctic Peninsula and West Antarctica) to R.D. Larter, C.-D. Hillenbrand (both BAS), D.A. Hodell (University of Cambridge) and A.G.C. Graham (University of Exeter). The data and samples collected will also be used in two Collaborative Gearing Scheme projects, an Antarctic Science Bursary project, a University of Cambridge PhD studentship, and within the National Capability remit of the BAS Science Teams in “Geology and Geophysics” and “Palaeoenvironments and Climate Change”. These projects are: • Tracing and reconstructing the neodymium and carbon isotopic composition of circum-Antarctic waters (CGS-100, PI: A.M. Piotrowski, Department of Earth Sciences, University of Cambridge; cruise participants: A.M. Piotrowski and T.J. Williams). • Structural characterisation of Late Quaternary sediments from West Antarctic contourite drifts using three dimensional X-ray imaging (CT-scanning) (CGS-98, PI: C. Ó Cofaigh, Department of Geography, Durham University; cruise participant: J. Horrocks) • Tracing the Quaternary evolution of the Antarctic Peninsula and West Antarctic Ice Sheets using lead isotopes in ice-rafted feldspar mineral grains (Antarctic Science Bursary awarded to C. Cook). • Seismic imaging of oceanographic structures and processes in the Southern Ocean south of the Polar Front (component of University of Cambridge/BP Institute PhD studentship; primary supervisor: N.J. White, Department of Earth Sciences, University of Cambridge; PhD student and cruise participant: K.L. Gunn). • Modelling crustal structure across the Bellingshausen Gravity Anomaly and oceanic fracture zones formed at the Antarctic-Phoenix Ridge through integration of marine potential field and seismic data (Collaboration between two BAS Science Teams; cruise participant: T.A.R.M. Jordan). 2 The cruise also provided support for physical oceanography projects by deploying six Argo floats and rescuing a malfunctioning sea glider. Towards the end of the cruise, RRS James Clark Ross was diverted to Rothera to uplift 16 personnel who had been flown across from Halley in two ALCI Basler aircraft because the sea ice situation in the Weddell Sea was considered to pose a significant risk to the scheduled last call of the season at Halley by RRS Ernest Shackleton. This uplift resulted in a two-day delay to arrival at Punta Arenas at the end of the cruise, which was in addition to a two-day extension already agreed as a result of departure from Punta Arenas having been delayed by slow refuelling. Adverse weather conditions, particularly during the first half of the cruise, resulted in more downtime than the amount of contingency time that had been allowed in the proposal. As a result, one less piston core and about 20% fewer line-km of seismic data were collected than had been planned. Nevertheless, the key objectives were achieved and the cores and data that were collected are of very good quality. The data and cores collected on cruise JR298, combined with existing data and cores, should satisfy all of the requirements of the Site Characterisation Panel and the Environmental Protection and Safety Panel of IODP. They will also provide a good basis for addressing the science objectives set out in the UK-IODP Site Survey Investigation proposal and those of the ancillary projects listed above