Anisotropic Magneto-conductance of InAs Nanowire: Angle Dependent Suppression of 1D Weak Localization

The magneto-conductance of an InAs nanowire is investigated with respect to the relative orientation between external magnetic field and the nanowire axis. It is found that both the perpendicular and the parallel magnetic fields induce a positive magneto-conductance. Yet the parallel magnetic field induced longitudinal magneto-conductance has a smaller magnitude. This anisotropic magneto-transport phenomenon is studied as a function of temperature, magnetic field strength and at an arbitrary angle between the magnetic field and the nanowire. We show that the observed effect is in quantitative agreement with the suppression of one-dimensional (1D) weak localization

Lepton flavor violating Higgs boson decays in seesaw models: new discussions

The lepton flavor violating decay of the Standard Model-like Higgs boson (LFVHD), h->\mu\tau, is discussed in seesaw models at the one-loop level. Based on particular analytic expressions of Passarino-Veltman functions, the two unitary and 't Hooft Feynman gauges are used to compute the branching ratio of LFVHD and compare with results reported recently. In the minimal seesaw (MSS) model, the branching ratio was investigated in the whole valid range 10^{-9}-10^{15} GeV of new neutrino mass scale m_{n_6}. Using the Casas-Ibarra parameterization, this branching ratio enhances with large and increasing m_{n_6}. But the maximal value can reach only order of 10^{-11}. Interesting relations of LFVHD predicted by the MSS and inverse seesaw (ISS) model are discussed. The ratio between two LFVHD branching ratios predicted by the ISS and MSS is simply m^2_{n_6}\mu^{-2}_X, where \mu_X is the small neutrino mass scale in the ISS. The consistence between different calculations is shown precisely from analytical approach.Comment: 4 figures, 26 pages, some analytic formulas and statements are corrected. Main results are unchanged. New references added. Version published in NP

Local anaesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro

Retrospective studies indicate that the use of regional anesthesia can reduce cancer recurrence after surgery which could be due to ranging from immune function preservation to direct molecular mechanisms. This study was to investigate the effects of bupivacaine on ovarian and prostate cancer cell biology and the underlying molecular mechanisms. Cell viability, proliferation and migration of ovarian carcinoma (SKOV-3) and prostate carcinoma (PC-3) were examined following treatment with bupivacaine. Cleaved caspase 3, 8 and 9, and GSK-3β, pGSK-3β(tyr216) and pGSK-3β(ser9) expression were assessed by immunofluorescence. FAS ligand neutralization, caspase and GSK-3 inhibitors and GSK-3β siRNA were applied to further explore underlying mechanisms. Clinically relevant concentrations of bupivacaine reduced cell viability and inhibited cellular proliferation and migration in both cell lines. Caspase 8 and 9 inhibition generated partial cell death reversal in SKOV-3, whilst only caspase 9 was effective in PC-3. Bupivacaine increased the phosphorylation of GSK-3β(Tyr216) in SKOV-3 but without measurable effect in PC3. GSK-3β inhibition and siRNA gene knockdown decreased bupivacaine induced cell death in SKOV-3 but not in PC3. Our data suggests that bupivacaine has direct ‘anti-cancer’ properties through the activation of intrinsic and extrinsic apoptotic pathways in ovarian cancer but only the intrinsic pathway in prostate cancer

Farmland Leasing: South Dakota Farmland Leasing 2003

Nearly 40% of South Dakota agricultural land is operated under a leasing agreement. Presented in this report are recent and longer term trends in land tenure, ownership, and leasing, based on Census of Agriculture data and related materials. Also presented are findings from the 1 996 farmland leasing survey completed by 513 South Dakota farm operators: (1) characteristics of rental market participants and of the farmland leasing market, (2) detailed provisions of cash leases and share leases for cropland, and (3) economic evaluation of farmland leasing arrangements. Information from the 1996 survey provides a comprehensive and statistically valid benchmark of agricultural land leasing in South Dakota, with primary emphasis on cropland leasing arrangements. This is the most comprehensive statewide study of South Dakota farmland rental markets since 1986. In many respects this publication updates and extends findings from the 1986 study reported in B704, Farmland leasing in South Dakota, published by the South Dakota Agricultural Experiment Station (Peterson and Janssen, 1988). This report should b e o f particular interest to renters and landlords, loan officers, realtors and appraisers, agricultural researchers, and others interested in farmland rental market developments

Temperature driven structural phase transition for trapped ions and its experimental detection

A Wigner crystal formed with trapped ion can undergo structural phase transition, which is determined only by the mechanical conditions on a classical level. Instead of this classical result, we show that through consideration of quantum and thermal fluctuation, a structural phase transition can be solely driven by change of the system's temperature. We determine a finite-temperature phase diagram for trapped ions using the renormalization group method and the path integral formalism, and propose an experimental scheme to observe the predicted temperature-driven structural phase transition, which is well within the reach of the current ion trap technology.Comment: 4 pages, 5 figure

RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells

Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC. Dicer, a ribonuclease III endoribonuclease, plays a critical role in the control of microRNA maturation in C-MSC, but its role in regulating C-MSC energy metabolism is largely unknown. In this study, we found that Dicer knockout led to concurrent increase in both cell proliferation and apoptosis in C-MSC compared to Dicer floxed C-MSC. We analyzed mitochondrial oxidative phosphorylation by quantifying cellular oxygen consumption rate (OCR), and glycolysis by quantifying the extracellular acidification rate (ECAR), in C-MSC with/without Dicer gene deletion. Dicer gene deletion significantly reduced mitochondrial oxidative phosphorylation while increasing glycolysis in C-MSC. Additionally, Dicer gene deletion selectively reduced the expression of β-oxidation genes without affecting the expression of genes involved in the tricarboxylic acid (TCA) cycle or electron transport chain (ETC). Finally, Dicer gene deletion reduced the copy number of mitochondrially encoded 1,4-Dihydronicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase core subunit 6 (MT-ND6), a mitochondrial-encoded gene, in C-MSC. In conclusion, Dicer gene deletion induced a metabolic shift from oxidative metabolism to aerobic glycolysis in C-MSC, suggesting that Dicer functions as a metabolic switch in C-MSC, which in turn may regulate proliferation and environmental adaptation