Advances in oncolytic herpes simplex virus and adenovirus therapy for recurrent glioma

Recurrent glioma treatment is challenging due to molecular heterogeneity and treatment resistance commonly observed in these tumors. Researchers are actively pursuing new therapeutic strategies. Oncolytic viruses have emerged as a promising option. Oncolytic viruses selectively replicate within tumor cells, destroying them and stimulating the immune system for an enhanced anticancer response. Among Oncolytic viruses investigated for recurrent gliomas, oncolytic herpes simplex virus and oncolytic adenovirus show notable potential. Genetic modifications play a crucial role in optimizing their therapeutic efficacy. Different generations of replicative conditioned oncolytic human adenovirus and oncolytic HSV have been developed, incorporating specific modifications to enhance tumor selectivity, replication efficiency, and immune activation. This review article summarizes these genetic modifications, offering insights into the underlying mechanisms of Oncolytic viruses’ therapy. It also aims to identify strategies for further enhancing the therapeutic benefits of Oncolytic viruses. However, it is important to acknowledge that additional research and clinical trials are necessary to establish the safety, efficacy, and optimal utilization of Oncolytic viruses in treating recurrent glioblastoma

Full Operating Range Optimization Design Method of LLC Resonant Converter in Marine DC Power Supply System

The marine DC power supply system is the key to a ship’s power supply, which needs to convert the energy from storage batteries or distributed power generation units into stable DC voltage for electric propulsion or the ship’s electronics. The LLC resonant converter can be used as the key power conversion link in the marine DC power supply system due to its ability to realize electrical isolation in a high-power environment and soft switching within a wide load range. Aiming at the problem of sudden changes in voltage gain at a high switching frequency under light load conditions and the problem of insufficient voltage gain under heavy load conditions due to the parasitic parameters of power devices (mainly referring to the junction capacitor), this paper first proposes a full operating range performance optimization design method. By adding an auxiliary circuit that can be opened according to the operating conditions and a multi-objective particle swarm parameter optimization method that considers the converter loss and voltage gain under heavy load conditions, the performance of the LLC resonant converter can be improved in a full range of operating conditions. Finally, the effectiveness of the proposed method is verified by an experimental prototype and compared with the conventional methods and existing solutions to highlight the superiority of the proposed method in this paper

Dual-Channel Cosine Function Based ITD Estimation for Robust Speech Separation

In speech separation tasks, many separation methods have the limitation that the microphones are closely spaced, which means that these methods are unprevailing for phase wrap-around. In this paper, we present a novel speech separation scheme by using two microphones that does not have this restriction. The technique utilizes the estimation of interaural time difference (ITD) statistics and binary time-frequency mask for the separation of mixed speech sources. The novelties of the paper consist in: (1) the extended application of delay-and-sum beamforming (DSB) and cosine function for ITD calculation; and (2) the clarification of the connection between ideal binary mask and DSB amplitude ratio. Our objective quality evaluation experiments demonstrate the effectiveness of the proposed method

Clinical significance of tumor deposits in gastric cancer after radical gastrectomy: a propensity score matching study

Abstract Objective The value of tumor deposits (TDs) in the prognosis and staging of gastric cancer (GC) is still under debate. This study aims to evaluate the prognostic value of TDs and the best ways to incorporate TDs in the TNM classification of GC. Methods Patients (n = 3460) undergoing curative gastrectomy for GC in the West China Hospital from 2005 to 2017 were retrospectively reviewed and divided into two groups according to the TD status (positive vs. negative). Later, clinicopathological features and overall survival (OS) between the two groups were compared. Thereafter, the associations between the presence of TD and other clinicopathological factors were evaluated through logistic regression. In addition, univariate and multivariate Cox regression were conducted for determining prognostic factors. The possibility of selection bias was reduced through conducting the 1:1 propensity score matching (PSM) analysis. The modified classification systems proposed previously that incorporated TDs into the TNM staging system were assessed. Results There were 10.5% of patients (362/3460) diagnosed with TDs. TDs were significantly related to unfavorable factors such as advanced T stage and N stage and independently associated with poor prognosis. The 5-year OS of patients with TDs was significantly lower than that of patients without TDs (31.0% vs. 60.9%, P < 0.001), whereas higher than that of patients with peritoneal metastasis (31.0% vs. 5.0%, P < 0.001). In patients receiving chemotherapy, the 5-year OS of patients with TDs was also significantly lower than that of patients without TDs (42.0% vs. 50.9%, P = 0.026). Moreover, the system incorporating TDs in the TNM classification as metastatic lymph nodes outperformed others. Conclusions TDs are related to the aggressive characteristics and are an independent prognostic factor for GC. Incorporating TDs in the TNM classification as the metastatic lymph nodes increases the accuracy in predicting prognosis

Additional file 1 of Clinical significance of tumor deposits in gastric cancer after radical gastrectomy: a propensity score matching study

Additional file 1

A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

The B cell survival factor (TNFSF13B/BAFF) is often elevated in autoimmune diseases and is targeted in the clinic for the treatment of systemic lupus erythematosus. BAFF contains a loop region designated the flap, which is dispensable for receptor binding. Here we show that the flap of BAFF has two functions. In addition to facilitating the formation of a highly active BAFF 60-mer as shown previously, it also converts binding of BAFF to TNFRSF13C (BAFFR) into a signaling event via oligomerization of individual BAFF-BAFFR complexes. Binding and activation of BAFFR can therefore be targeted independently to inhibit or activate the function of BAFF. Moreover, structural analyses suggest that the flap of BAFF 60-mer temporarily prevents binding of an anti-BAFF antibody (belimumab) but not of a decoy receptor (atacicept). The observed differences in profiles of BAFF inhibition may confer distinct biological and clinical efficacies to these therapeutically relevant inhibitors