Capacitive Touch Panel with Low Sensitivity to Water Drop employing Mutual-coupling Electrical Field Shaping Technique

This paper proposes a novel method to reduce the water interference on the touch panel based on mutual-capacitance sensing in human finger detection. As the height of a finger (height >10 mm) is far larger than that of a water-drop (height 10 mm) and low in the low-height space (height <1 mm), the sensing cell can be designed to distinguish the finger from the water-drop. To achieve this density distribution of the electrical field, the mutual-coupling electrical field shaping (MEFS) technique is employed to build the sensing cell. The drawback of the MEFS sensing cell is large parasitic capacitance, which can be overcome by a readout IC with low sensitivity to parasitic capacitance. Experiments show that the output of the IC with the MEFS sensing cell is 1.11 V when the sensing cell is touched by the water-drop and 1.23 V when the sensing cell is touched by the finger, respectively. In contrast, the output of the IC with the traditional sensing cell is 1.32 and 1.33 V when the sensing cell is touched by the water-drop and the finger, respectively. This demonstrates that the MEFS sensing cell can better distinguish the finger from the water-drop than the traditional sensing cell does.National Research Foundation (NRF)Accepted versionThis work was supported in part by the National Natural Science Foundation of China (NSFC) under Grant 61771363, in part by the China Scholarship Council (CSC) under Grant 201706960042, and in part by the National Research Foundation of Singapore under Grant NRF-CRP11-2012-01

Focused ultrasound-mediated blood-brain barrier opening combined with magnetic targeting cytomembrane based biomimetic microbubbles for glioblastoma therapy

Abstract Glioblastoma is the most common type of brain tumor. Due to the presence of the blood-brain barrier, the effects of chemotherapy have been unsatisfactory. The combination of focused ultrasound and microbubbles to reversibly open the blood-brain barrier is now considered a key factor in improving treatment outcomes of glioblastoma. In this study, we developed bionic drug delivery microbubbles, which in combination with focused ultrasound had an obvious inhibitory effect on glioblastoma. We extracted the brain microvascular cell membranes, combined them with lipid components, and loaded them with superparamagnetic iron oxide and doxorubicin to prepare biomimetic drug delivery microbubbles (FeDOX@cellMBs). We demonstrated that FeDOX@cellMBs retained the intrinsic properties of loading, such as magnetic properties and drug toxicity, both in vitro and in vivo. FeDOX@cellMBs exhibited good tumor targeting and uptake under the combined action of magnetic and focused ultrasound. Importantly, the FeDOX@cellMBs demonstrated excellent internal stability and effectively inhibited tumor growth in orthotopic glioblastoma mice. Finally, organ H&E staining confirmed that FeDOX@cellMBs were safe for use. In conclusion, FeDOX@cellMBs successfully penetrated the blood-brain barrier and effectively inhibited glioblastoma growth under the combined effects of focused ultrasound and magnetic stimulation. These results provide a new approach for the treatment of glioblastoma, with implications for future clinical translation