Trifolirhizin relieves renal injury in a diabetic nephropathy model by inducing autophagy and inhibiting oxidative stress through the regulation of PI3K/AKT/mTOR pathway

Purpose: To evaluate the effects of trifolirhizin on diabetic nephropathy (DN), and the mechanism of action. Methods: Male db/db mice (8 weeks, n = 24) and age-matched control mice (n = 6) were obtained. The mice were further divided into four groups and administered increasing doses of trifolirhizin (0, 12.5, 25 and 50 mg/kg). Histological analysis of renal tissues were performed by H & E staining. Blood urea nitrogen (BUN) and creatinine were determined using enzyme-linked immunosorbent assay (ELISA). Immunoblot and TUNEL assay were performed to investigate the effect of trifolirhizin on autophagy and apoptosis, while ELISA and dihydroethidium (DHE) staining were conducted to evaluate reactive oxygen species (ROS), malondialdehyde (MDA) and superoxide dismutase (SOD) levels. The effect of trifolirhizin on PI3K/AKT/mTOR pathway was determined using Immunoblot assays. Results: Trifolirhizin alleviated renal injury in diabetic mice, and also activate autophagy and inhibited apoptosis in the renal tissues in diabetic mice (p < 0.001). In addition, trifolirhizin inhibited the oxidative stress response in the renal tissue in diabetic mice (p < 0.001). Trifolirhizin further inhibited PI3K/AKT/mTOR pathway and therefore relieved renal injury in the diabetic nephropathy model (p < 0.001). Conclusion: Trifolirhizin alleviates renal injury in diabetic mice, activates autophagy, and inhibits apoptosis in renal tissue of diabetic mice. Therefore, trifolirhizin is a promising a promising drug for the treatment of DN

Electron on solid neon -- a new solid-state single-electron qubit platform

The promise of quantum computing has driven a persistent quest for new qubit platforms with long coherence, fast operation, and large scalability. Electrons, ubiquitous elementary particles of nonzero charge, spin, and mass, have commonly been perceived as paradigmatic local quantum information carriers. Despite superior controllability and configurability, their practical performance as qubits via either motional or spin states depends critically on their material environment. Here we report our experimental realization of a new qubit platform based upon isolated single electrons trapped on an ultraclean solid neon surface in vacuum. By integrating an electron trap in a circuit quantum electrodynamics architecture, we achieve strong coupling between the motional states of a single electron and microwave photons in an on-chip superconducting resonator. Qubit gate operations and dispersive readout are used to measure the energy relaxation time $T_1$ of $15~\mu$s and phase coherence time $T_2$ over 200 ns, indicating that the electron-on-solid-neon qubit already performs near the state of the art as a charge qubit.Comment: 7 pages, 3 figure

A 1.16-{\mu}m-radius disk cavity in a sunflower-type circular photonic crystal with ultrahigh quality factor

We present a 1.16-\mum-radius disk cavity with ultrahigh quality (Q) factor by embedding the disk into a sunflower-type circular photonic crystal (CPC). The band gap of the CPC reduces the bending loss of the whispering-gallery mode of the disk, leading to a simulated Q of 10^7, at least one order of magnitude higher than a bare disk of the same size. The design is experimentally verified with a record high loaded Q of 7.4 \times 10^5 measured from an optimized device fabricated on a silicon-on-insulator substrate