Links between Psychological Contract and Job Performance of Employee in E-Business Company

The performance of staffs directly determines competitive power of enterprise in fierce market, and it also influences the long-term development of enterprise. If enterprise motivate employees only by virtue of economic contract, it cannot effectively assure staff performance, because psychological contract also affects employee’s work behavior and work attitude. This is especially notable in E-Business company because most E-business companies have a high turn-over rate and most of their employees are 80s or 90s. The essence of enterprise competition is talents, the emphasis on psychological contract can effectively reduce employee turnover rate and improve employee’s working efficiency in E-Business company. This paper sums up the connotations and features of psychological contract and job performance and puts forward relationship model of psychological contract and job performance. We make employees of Y company as the object of empirical study and carry out questionnaire research, use SPSS software to develop statistical data analysis. It shows that psychological contract has significant positive effect on job performance of E-business company. Finally, this paper puts forward some management strategy for enterprises to enhance psychological contract of employees according to the result of survey

Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway

<p>Abstract</p> <p>Background</p> <p>To explore the effects of Osthole on the proliferation, cell cycle and apoptosis of human lung cancer A549 cells.</p> <p>Methods</p> <p>Human lung cancer A549 cells were treated with Osthole at different concentrations. Cell proliferation was measured using the MTT assay. Cell cycle was evaluated using DNA flow cytometry analysis. Induction of apoptosis was determined by flow cytometry and fluorescent microscopy. The expressions of Cyclin B1, p-Cdc2, Bcl-2, Bax, t-Akt and p-Akt were evaluated by Western blotting.</p> <p>Results</p> <p>Osthole inhibited the growth of human lung cancer A549 cells by inducing G2/M arrest and apoptosis. Western blotting demonstrated that Osthole down-regulated the expressions of Cyclin B1, p-Cdc2 and Bcl-2 and up-regulated the expressions of Bax in A549 cells. Inhibition of PI3K/Akt signaling pathway was also observed after treating A549 cells with Osthole.</p> <p>Conclusions</p> <p>Our findings suggest that Osthole may have a therapeutic application in the treatment of human lung cancer.</p

A possible role of crustacean cardioactive peptide in regulating immune response in hepatopancreas of mud crab

Crustacean cardioactive peptide (CCAP), a cyclic amidated non-apeptide, is widely found in arthropods. The functions of CCAP have been revealed to include regulation of heart rate, intestinal peristalsis, molting, and osmotic pressure. However, to date, there has not been any report on the possible involvement of CCAP in immunoregulation in crustaceans. In this study, a CCAP precursor (designated as Sp-CCAP) was identified in the commercially important mud crab Scylla paramamosain, which could be processed into four CCAP-associated peptides and one mature peptide (PFCNAFTGC-NH2). Bioinformatics analysis indicated that Sp-CCAP was highly conserved in crustaceans. RT-PCR results revealed that Sp-CCAP was expressed in nerve tissues and gonads, whereas the Sp-CCAP receptor gene (Sp-CCAPR) was expressed in 12 tissues of S. paramamosain, including hepatopancreas. In situ hybridization further showed that an Sp-CCAPR-positive signal is mainly localized in the F-cells of hepatopancreas. Moreover, the mRNA expression level of Sp-CCAPR in the hepatopancreas was significantly up-regulated after lipopolysaccharide (LPS) or polyriboinosinic polyribocytidylic acid [Poly (I:C)] challenge. Meanwhile, the mRNA expression level of Sp-CCAPR, nuclear transcription factor NF-kappa B homologs (Sp-Dorsal and Sp-Relish), member of mitogen-activated protein kinase (MAPK) signaling pathway (Sp-P38), pro-inflammatory cytokines factor (Sp-TNFSF and Sp-IL16), and antimicrobial peptide (Sp-Lysozyme, Sp-ALF, Sp-ALF4, and Sp-ALF5) in the hepatopancreas were all up-regulated after the administration of synthetic Sp-CCAP mature peptide both in vivo and in vitro. The addition of synthetic Sp-CCAP mature peptide in vitro also led to an increase in nitric oxide (NO) concentration and an improved bacterial clearance ability in the hepatopancreas culture medium. The present study suggested that Sp-CCAP signaling system might be involved in the immune responses of S. paramamosain by activating immune molecules on the hepatopancreas. Collectively, our findings shed new light on neuroendocrine-immune regulatory system in arthropods and could potentially provide a new strategy for disease prevention and control for mud crab aquaculture

Similarity-Aware Multimodal Prompt Learning for Fake News Detection

The standard paradigm for fake news detection mainly utilizes text information to model the truthfulness of news. However, the discourse of online fake news is typically subtle and it requires expert knowledge to use textual information to debunk fake news. Recently, studies focusing on multimodal fake news detection have outperformed text-only methods. Recent approaches utilizing the pre-trained model to extract unimodal features, or fine-tuning the pre-trained model directly, have become a new paradigm for detecting fake news. Again, this paradigm either requires a large number of training instances, or updates the entire set of pre-trained model parameters, making real-world fake news detection impractical. Furthermore, traditional multimodal methods fuse the cross-modal features directly without considering that the uncorrelated semantic representation might inject noise into the multimodal features. This paper proposes a Similarity-Aware Multimodal Prompt Learning (SAMPLE) framework. First, we incorporate prompt learning into multimodal fake news detection. Prompt learning, which only tunes prompts with a frozen language model, can reduce memory usage significantly and achieve comparable performances, compared with fine-tuning. We analyse three prompt templates with a soft verbalizer to detect fake news. In addition, we introduce the similarity-aware fusing method to adaptively fuse the intensity of multimodal representation and mitigate the noise injection via uncorrelated cross-modal features. For evaluation, SAMPLE surpasses the F1 and the accuracies of previous works on two benchmark multimodal datasets, demonstrating the effectiveness of the proposed method in detecting fake news. In addition, SAMPLE also is superior to other approaches regardless of few-shot and data-rich settings

Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review

Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological features may be related to axonal transport deficits in neurons, which lead to failures in pathological protein targeting to specific sites for degradation and organelle transportation to designated areas needed for normal physiological functioning. Axonal transport deficits are most likely early pathological events in such diseases and gradually lead to the loss of axonal integrity and other degenerative changes. In this review, we investigated reports of mechanisms underlying the development of axonal transport deficits in a variety of common neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease and Huntington’s disease to provide new ideas for therapeutic targets that may be used early in the disease process. The mechanisms can be summarized as follows: (1) motor protein changes including expression levels and post-translational modification alteration; (2) changes in microtubules including reducing stability and disrupting tracks; (3) changes in cargoes including diminished binding to motor proteins. Future studies should determine which axonal transport defects are disease-specific and whether they are suitable therapeutic targets in neurodegenerative diseases

Lipase-ultrasound assisted synthesis of polyesters

Poly (ethylene glutarate), poly (ethylene malonate) and poly (ethylene phthalate), were enzymatically synthesized by immobilized Candida antarctica lipase B in solvent free conditions. The synthesis of these polyesters was based on the ester-ester exchange reaction between ethylene glycol diacetate and di-ethyl glutarate, di-benzyl malonate, di-n-octyl phthalate to produce poly (ethylene glutarate), poly (ethylene malonate) and poly (ethylene phthalate), respectively. The effect of ultrasound and PET polymeric beads on the polyester synthesis was evaluated and showed to improve the synthesis of all polyesters. Ultrasound, as a green solvent-free technology, showed high potentiality for the polyester synthesis intensification.All authors gratefully acknowledge the financial support provided by International Joint Research Laboratory for Textile and Fibre Bioprocesses at Jiangnan University. The authors are also thankful to the Department of Chemical Engineering, Institute of Chemical Technology, Matunga (E), Mumbai-400019, India and to the Bioprocess and Bio nanotechnology Research Group (BBRG) of University of Minho. Authors would like also to acknowledge the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020 Programa Operacional Regional do Norte and to the Fundamental Research Funds for the Central Universities (No. JUSRP51622A) 2016, Jiangsu Province Scientific Research Innovation Project for Academic Graduate Students (No. KYLX16_0788).info:eu-repo/semantics/publishedVersio

Lipase-ultrasound assisted synthesis of polyesters

Poly (ethylene glutarate), poly (ethylene malonate) and poly (ethylene phthalate), were enzymatically synthesized by immobilized Candida antarctica lipase B in solvent free conditions. The synthesis of these polyesters was based on the ester-ester exchange reaction between ethylene glycol diacetate and di-ethyl glutarate, di-benzyl malonate, di-n-octyl phthalate to produce poly (ethylene glutarate), poly (ethylene malonate) and poly (ethylene phthalate), respectively. The effect of ultrasound and PET polymeric beads on the polyester synthesis was evaluated and showed to improve the synthesis of all polyesters. Ultrasound, as a green solvent-free technology, showed high potentiality for the polyester synthesis intensification.All authors gratefully acknowledge the financial support provided by International Joint Research Laboratory for Textile and Fibre Bioprocesses at Jiangnan University. The authors are also thankful to the Department of Chemical Engineering, Institute of Chemical Technology, Matunga (E), Mumbai-400019, India and to the Bioprocess and Bio nanotechnology Research Group (BBRG) of University of Minho. Authors would like also to acknowledge the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020 Programa Operacional Regional do Norte and to the Fundamental Research Funds for the Central Universities (No. JUSRP51622A) 2016, Jiangsu Province Scientific Research Innovation Project for Academic Graduate Students (No. KYLX16_0788).info:eu-repo/semantics/publishedVersio