Period halving of Persistent Currents in Mesoscopic Mobius ladders

We investigate the period halving of persistent currents(PCs) of non-interacting electrons in isolated mesoscopic M\"{o}bius ladders without disorder, pierced by Aharonov-Bhom flux. The mechanisms of the period halving effect depend on the parity of the number of electrons as well as on the interchain hopping. Although the data of PCs in mesoscopic systems are sample-specific, some simple rules are found in the canonical ensemble average, such as all the odd harmonics of the PCs disappear, and the signals of even harmonics are non-negative. {PACS number(s): 73.23.Ra, 73.23.-b, 68.65.-k}Comment: 6 Pages with 3 EPS figure

User Migration across Multiple Social Media Platforms

After Twitter's ownership change and policy shifts, many users reconsidered their go-to social media outlets and platforms like Mastodon, Bluesky, and Threads became attractive alternatives in the battle for users. Based on the data from over 16,000 users who migrated to these platforms within the first eight weeks after the launch of Threads, our study examines: (1) distinguishing attributes of Twitter users who migrated, compared to non-migrants; (2) temporal migration patterns and associated challenges for sustainable migration faced by each platform; and (3) how these new platforms are perceived in relation to Twitter. Our research proceeds in three stages. First, we examine migration from a broad perspective, not just one-to-one migration. Second, we leverage behavioral analysis to pinpoint the distinct migration pattern of each platform. Last, we employ a large language model (LLM) to discern stances towards each platform and correlate them with the platform usage. This in-depth analysis illuminates migration patterns amid competition across social media platforms

Load-shedding probabilities with hybrid renewable power generation and energy storage

The integration of renewable energy resources, such as solar and wind power, into the electric grid presents challengs partly due to the intermittency in the power output. These difficulties can be alleviated by effectively utilizing energy storage. We consider, as a case study, the integration of renewable resources into the electric power generation portfolio of an island off the coast of Southern California, Santa Catalina Island, and investigate the feasibility of replacing diesel generation entirely with solar photovoltaics (PV) and wind turbines, supplemented with energy storage. We use a simple storage model alongside a combination of renewables and varying load-shedding characterizations to determine the appropriate area of PV cells, number of wind turbines, and energy storage capacity needed to stay below a certain threshold probability for load-shedding over a pre-specified period of time and long-term expected fraction of time at load-shedding

Hiformer: Heterogeneous Feature Interactions Learning with Transformers for Recommender Systems

Learning feature interaction is the critical backbone to building recommender systems. In web-scale applications, learning feature interaction is extremely challenging due to the sparse and large input feature space; meanwhile, manually crafting effective feature interactions is infeasible because of the exponential solution space. We propose to leverage a Transformer-based architecture with attention layers to automatically capture feature interactions. Transformer architectures have witnessed great success in many domains, such as natural language processing and computer vision. However, there has not been much adoption of Transformer architecture for feature interaction modeling in industry. We aim at closing the gap. We identify two key challenges for applying the vanilla Transformer architecture to web-scale recommender systems: (1) Transformer architecture fails to capture the heterogeneous feature interactions in the self-attention layer; (2) The serving latency of Transformer architecture might be too high to be deployed in web-scale recommender systems. We first propose a heterogeneous self-attention layer, which is a simple yet effective modification to the self-attention layer in Transformer, to take into account the heterogeneity of feature interactions. We then introduce \textsc{Hiformer} (\textbf{H}eterogeneous \textbf{I}nteraction Trans\textbf{former}) to further improve the model expressiveness. With low-rank approximation and model pruning, \hiformer enjoys fast inference for online deployment. Extensive offline experiment results corroborates the effectiveness and efficiency of the \textsc{Hiformer} model. We have successfully deployed the \textsc{Hiformer} model to a real world large scale App ranking model at Google Play, with significant improvement in key engagement metrics (up to +2.66\%)

Exploring metabolism in scleroderma reveals opportunities for pharmacological intervention for therapy in fibrosis

Background: Recent evidence has indicated that alterations in energy metabolism play a critical role in the pathogenesis of fibrotic diseases. Studies have suggested that 'metabolic reprogramming' involving the glycolysis and oxidative phosphorylation (OXPHOS) in cells lead to an enhanced generation of energy and biosynthesis. The aim of this study was to assess the molecular basis of changes in fibrotic metabolism in systemic sclerosis (Scleroderma; SSc) and highlight the most appropriate targets for anti-fibrotic therapies. Materials and methods: Dermal fibroblasts were isolated from five SSc patients and five healthy donors. Cells were cultured in medium with/without TGF-β1 and with/without ALK5, pan-PIM or ATM kinase inhibitors. Extracellular flux analyses were performed to evaluate glycolytic and mitochondrial respiratory function. The mitochondrial network in TMRM-stained cells was visualized by confocal laser-scanning microscopy, followed by semi-automatic analysis on the ImageJ platform. Protein expression of ECM and fibroblast components, glycolytic enzymes, subunits of the five OXPHOS complexes, and dynamin-related GTPases and receptors involved in mitochondrial fission/fusion were assessed by western blotting. Results: Enhanced mitochondrial respiration coupled to ATP production was observed in SSc fibroblasts at the expense of spare respiratory capacity. Although no difference was found in glycolysis when comparing SSc with healthy control fibroblasts, levels of phophofructokinase-1 isoform PFKM were significantly lower in SSc fibroblasts (P<0.05). Our results suggest that the number of respirasomes is decreased in the SSc mitochondria; however, the organelles formed a hyperfused network, which is thought to increase mitochondrial ATP production through complementation. The increased mitochondrial fusion correlated with a change in expression levels of regulators of mitochondrial morphology, including decreased levels of DRP1, increased levels of MIEF2 and changes in OPA1 isoform ratios. TGF-β1 treatment strongly stimulated glycolysis and mitochondrial respiration and induced the expression of fibrotic markers. The pan-PIM kinase inhibitor had no effect, whereas both ALK5 and ATM kinase inhibition abrogated TGF-β1-mediated fibroblast activation, and upregulation of glycolysis and respiration. Conclusions: Our data provide evidence for a novel mechanism(s) by which SSc fibroblasts exhibit altered metabolic programs and highlight changes in respiration and dysregulated mitochondrial morphology and function, which can be selectively targeted by small molecule kinase inhibitors

A Mechanochemical Reaction Cascade for Controlling Load-Strengthening of a Mechanochromic Polymer

We demonstrate an intermolecular reaction cascade to control the force which triggers crosslinking of a mechanochromic polymer of spirothiopyran (STP). Mechanochromism arises from rapid reversible force-sensitive isomerization of STP to a merocyanine, which reacts rapidly with activated C=C bonds. The concentration of such bonds, and hence the crosslinking rate, is controlled by force-dependent dissociation of a Diels–Alder adduct of anthracene and maleimide. Because the adduct requires ca. 1 nN higher force to dissociate at the same rate as that of STP isomerization, the cascade limits crosslinking to overstressed regions of the material, which are at the highest rate of material damage. Using comb polymers decreased the minimum concentration of mechanophores required to crosslinking by about 100-fold compared to previous examples of load-strengthening materials. The approach described has potential for controlling a broad range of reaction sequences triggered by mechanical load

Clinical investigation of CT-guided ozone-blowing and fumigation therapy for the chronic refractory cutaneous sinus and ulcer

The purpose of this article is to investigate the clinical effect of CT-guided ozone-blowing and fumigation in the treatment of chronic refractory cutaneous sinus and ulcer. Twenty-six cases of chronic refractory sinuses and ulcers caused by different diseases were retrospectively analyzed in our study. After sterilization, all patients were scanned by computed tomography and the sinuses and ulcers prelocated by CT were treated by O3-blowing and fumigation. Twenty-one patients treated with traditionalsurgery were randomly assigned into control group. A total number of 15 patients were completely cured in 45 days after receiving CT-guided ozone-blowing fumigation treatment. Four patients exhibited markedly therapeutic effects and three cases showed improvement. The effective ratio was 85%. In control group, seven patients were completely cured in 45 days after being treated by traditional surgery. Four patients exhibited markedly therapeutic effects and five cases showed improvement. Anobvious statistical difference exists between two groups. Application of CT-guided O3-blowing and fumigation therapy is an effective approach in the treatment of chronic refractory cutaneous ulcer and sinus with shorter therapeutic duration, less suffering, better curative effect and less adverse effect

Robustness and Generalization

We derive generalization bounds for learning algorithms based on their robustness: the property that if a testing sample is "similar" to a training sample, then the testing error is close to the training error. This provides a novel approach, different from the complexity or stability arguments, to study generalization of learning algorithms. We further show that a weak notion of robustness is both sufficient and necessary for generalizability, which implies that robustness is a fundamental property for learning algorithms to work

Effect of nano-C doping on the in-situ processed MgB2 tapes

The effect of nano-C doping on the microstructure and superconducting properties of Fe-sheathed MgB2 tapes prepared through the in-situ powder-in-tube method was studied. Heat treatment was performed at a low temperature of 650C for 1 h. Scanning electron microscopy investigation revealed that the smaller grain size of MgB2 in the samples with the C-doping. Further, the a-axis lattice parameter and transition temperature decreased monotonically with increasing doping level, which is due to the C substitution for B. High critical current density Jc values in magnetic fields were achieved in the doped samples because of the very fine-grained microstructure of the superconducting phase obtained with C doping.Comment: revised manuscript, 4 pages, 4 figures. to be published soo

Multi-Band Exotic Superconductivity in the New Superconductor Bi4O4S3

Resistivity, Hall effect and magnetization have been investigated on the new superconductor Bi4O4S3. A weak insulating behavior has been induced in the normal state when the superconductivity is suppressed. Hall effect measurements illustrate clearly a multiband feature dominated by electron charge carriers, which is further supported by the magnetoresistance data. Interestingly, a kink appears on the temperature dependence of resistivity at about 4 K at all high magnetic fields when the bulk superconductivity is completely suppressed. This kink can be well traced back to the upper critical field Hc2(T) in the low field region, and is explained as the possible evidence of residual Cooper pairs on the one dimensional chains.Comment: 5 pages, 5 figure