850 research outputs found
Ethyl 5-methyl-4-oxo-3-phenyl-2-propylamino-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate
The title compound, C19H21N3O3S, was synthesized via the aza-Wittig reaction of functionalized iminophosphorane with phenyl isocyanate under mild conditions. In the molecule, the fused thienopyrimidine ring system is essentially planar, with a maximum deviation of 0.072 (2) Å, and makes a dihedral angle of 60.11 (9)° with the phenyl ring. An intramolecular C—H⋯O hydrogen bond is present. The crystal packing is stabilized by intermolecular N—H⋯O and C—H⋯O hydrogen bonds
3-Isopropyl-2-(4-methoxyphenoxy)-1-benzofuro[3,2-d]pyrimidin-4(3H)-one
In the title compound, C20H18N2O4, all non-H atoms of the three fused rings of the benzofuro[3,2-d]pyrimidine system are almost coplanar (r.m.s. deviation 0.021 Å). The dihedral angle between the fused ring system and the benzene ring is 1.47 (12)°. Intramolecular and intermolecular C—H⋯O hydrogen bonds together with weak C—H⋯π interactions stabilize the structure
Role of Nrf2 in bone metabolism
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cytoprotective genes against oxidative and chemical insults. The lack of Nrf2 can induce pathologies in multiple organs. Nrf2 deficiency promotes osteoclast differentiation and osteoclast activity, which leads to an increase in bone resorption. The role of Nrf2 in osteoblast differentiation and osteoblast activity is more complex. Nrf2 mediates anabolic effects within an ideal range. Nrf2 deletion suppresses load induced bone formation and delays fracture healing. Overall, Nrf2 plays an important role in the regulation of bone homeostasis in bone cells
2-Methyl-4-trifluoromethyl-1,3-thiazole-5-carboxylic acid
In crystal of the title compound, C6H4F3NO2S, molecules are linked by O—H⋯N and C—H⋯O hydrogen bonds, forming chains
Nonlinear Decoupling Sliding Mode Control of Permanent Magnet Linear Synchronous Motor Based on α-th Order Inverse System Method
AbstractIn this paper, a nonlinear dynamic decoupling controller is proposed for the permanent magnet linear synchronous motor (PMLSM) servo system to improve dynamic operating performance. Firstly, the reversibility of the PMLSM mathematical model is analyzed, and it is proved that the system is reversible. Then an inverse system method is applied to the PMLSM servo system, and it is decoupled into a linear velocity subsystem and a linear current subsystem based on the α-th order inverse system method. Considering the both ideal linear subsystems are sensitive to parameter disturbances and various disturbances, a variable rate reaching law approach based subsystem sliding mode controller for higher system stability and robustness is proposed. Finally, simulation results are provided to demonstrate the effectiveness of the proposed control method
Ethyl 1-(6-chloro-3-pyridylmethyl)-5-ethoxymethyleneamino-1H-1,2,3-triazole-4-carboxylate
In the title compound, C14H16ClN5O3, there is evidence for significant electron delocalization in the triazolyl system. Intramolecular C—H⋯O and intermolecular C—H⋯O and C—H⋯N hydrogen bonds stabilize the structure
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