Analysis on the factors associated with COVID-19 infection among Chinese residents after the implementation of the 10 new rules to optimize COVID-19 response: a cross-sectional study

IntroductionThis study aimed to investigate the status of COVID-19 infection and the associated factors among Chinese residents after the implementation of the 10 New Rules to optimize COVID response.MethodsParticipants were recruited using convenience sampling. The study used self-filled questionnaires to examine COVID-19 infection and associated factors among Chinese residents, from December 29, 2022, to January 2, 2023. For the statistical analysis, descriptive and quantitative analyses were used. The potential risk factors for COVID-19 infection were identified by multivariable logistic regression analysis.ResultsAfter the adjustments in control strategies against COVID-19, the infection rate of COVID-19 was high among respondents, and 98.4% of individuals who tested positive showed symptoms including cough, fever, fatigue, headache, sore throat, nasal congestion, sputum production, muscle and joint pain, and runny nose. The main problems respondents reported were the shortage of drugs and medical supplies, the increased burden on families, and the unreliable information source of COVID-19 infection. Logistic regression showed that isolating patients with COVID-19 at home was associated with a lower risk of COVID-19 infection (OR = 0.58, 95%CI: 0.42–0.81).ConclusionCOVID-19 infection among residents is closely related to age, gender, and epidemic prevention measures. The government needs to strengthen education for individuals and centrally manage and properly address difficulties that may arise during COVID-19

Endocytosis of BRASSINOSTEROID INSENSITIVE1 is partly driven by a canonical tyr-based motif

Clathrin-mediated endocytosis (CME) and its core endocytic machinery are evolutionarily conserved across all eukaryotes. In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) sorts plasma membrane (PM) cargoes into vesicles through the recognition of motifs based on tyrosine or di-leucine in their cytoplasmic tails. However, in plants, very little is known on how PM proteins are sorted for CME and whether similar motifs are required. In Arabidopsis thaliana, the brassinosteroid (BR) receptor, BR INSENSITIVE1 (BRI1), undergoes endocytosis that depends on clathrin and AP-2. Here we demonstrate that BRI1 binds directly to the medium AP-2 subunit, AP2M. The cytoplasmic domain of BRI1 contains five putative canonical surface-exposed tyrosine-based endocytic motifs. The tyrosine-to-phenylalanine substitution in Y898KAI reduced BRI1 internalization without affecting its kinase activity. Consistently, plants carrying the BRI1Y898F mutation were hypersensitive to BRs. Our study demonstrates that AP-2-dependent internalization of PM proteins via the recognition of functional tyrosine motifs also operates in plants

Performance Analysis of Relay-Aided NOMA Optical Wireless Communication System in Underwater Turbulence Environment

Non-orthogonal multiple access (NOMA) is a promising technology to improve spectrum utilization effectively for underwater optical wireless communications (UOWC). To exploit the benefits of NOMA in a turbulent environment, cooperative transmission has been introduced in the NOMA–UOWC network. The existing studies on NOMA suggest that relay selection and power optimization are the main factors affecting system performance. In this paper, a general NOMA node pairing method and two power optimization schemes for NOMA–UOWC are proposed, and both schemes are proven to be strictly quasi-convex. The two optimization schemes are solved by the BFGS algorithm and the particle swarm algorithm, respectively. The effectiveness of the proposed schemes are evaluated by our simulations, and the main factors affecting the relay-aided NOMA performance are derived

Performance Analysis of Relay-Aided NOMA Optical Wireless Communication System in Underwater Turbulence Environment

Non-orthogonal multiple access (NOMA) is a promising technology to improve spectrum utilization effectively for underwater optical wireless communications (UOWC). To exploit the benefits of NOMA in a turbulent environment, cooperative transmission has been introduced in the NOMA–UOWC network. The existing studies on NOMA suggest that relay selection and power optimization are the main factors affecting system performance. In this paper, a general NOMA node pairing method and two power optimization schemes for NOMA–UOWC are proposed, and both schemes are proven to be strictly quasi-convex. The two optimization schemes are solved by the BFGS algorithm and the particle swarm algorithm, respectively. The effectiveness of the proposed schemes are evaluated by our simulations, and the main factors affecting the relay-aided NOMA performance are derived

Continuum Structural Layout in Consideration of the Balance of the Safety and the Properties of Structures

Abstract In the article, a new approach considering structural local failure for topology optimization of continuum structure is proposed. It aims at not only lowering the risk of local failure in the concerned structural regions, but also ensuring a good stiffness of the structure. The local failure may be caused by the structural uncertainties or possible structural fatigue. To this end, a criterion to evaluate the effect of one local failure on the structure is introduced. This criterion is minimized to reduce the probability of structural damage based on an initialized structure whose compliance is optimized. Solid Isotropic with Material Penalization (SIMP) method and Optimality Criteria (OC) method are combined to solve the design problem. The effectiveness of the proposed algorithm is verified by a series of numerical examples. Furthermore, experiments merging with additive manufacturing technique are taken to prove the practical ability of the method in actual engineering

Construction of dynamic three-dimensional microstructure for the hydration of cement using 3D image registration

Microstructure is one of the most important research issues in the field of cement hydration. The absence of imaging dynamic three-dimensional microstructure influences the investigation of cement hydration. Furthermore, it is impossible to confirm computer hydration models from real data perspective due to the lack of images of dynamic 3D microstructure. The evolution of the three-dimensional microstructure cannot be observed in situ easily. This article proposes an image registration-based approach to capture dynamic three-dimensional microstructure, whose original images are collected using microtomography. This is the first time that the dynamic 3D microstructure is imaged and analyzed for the hydration of cement. It allows imaging dynamic 3D microstructure for hydrating cement without using any extra equipment. Our research results indicate that the dynamic microstructure is captured easily with low cost and good precision.Web of Science17366565

Phosphorylation of ADAPTOR PROTEIN-2 μ-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots

ADAPTOR-ASSOCIATED PROTEIN KINASE1 (AAK1) is a known regulator of clathrin-mediated endocytosis in mammals. Human AAK1 phosphorylates the & mu;2 subunit of the ADAPTOR PROTEIN-2 (AP-2) complex (AP2M) and plays important roles in cell differentiation and development. Previous interactome studies discovered the association of AAK1 with AP-2 in Arabidopsis (Arabidopsis thaliana), but its function was unclear. Here, genetic analysis revealed that the Arabidopsis aak1 and ap2m mutants both displayed altered root tropic growth, including impaired touch- and gravity-sensing responses. In Arabidopsis, AAK1-phosphorylated AP2M on Thr-163, and expression of the phospho-null version of AP2M in the ap2m mutant led to an aak1-like phenotype, whereas the phospho-mimic forms of AP2M rescued the aak1 mutant. In addition, we found that the AAK1-dependent phosphorylation state of AP2M modulates the frequency distribution of endocytosis. Our data indicate that the phosphorylation of AP2M on Thr-163 by AAK1 fine-tunes endocytosis in the Arabidopsis root to control its tropic growth