A numerical study of axisymmetric wave propagation in buried fluid-filled pipes for optimizing the vibro-acoustic technique when locating gas pipelines

Buried pipeline systems play a vital role in energy storage and transportation, especially for fluid energies like water and gas. The ability to locate buried pipes is of great importance since it is fundamental for leakage detection, pipeline maintenance, and pipeline repair. The vibro-acoustic locating method, as one of the most effective detection technologies, has been studied by many researchers. However, previous studies have mainly focused on vibro-acoustic propagation in buried water pipes. Limited research has been conducted on buried gas pipes. In this paper, the behavior of gas-dominated wave motion will be investigated and compared against water-dominated wave motion by adapting an established analytical model of axisymmetric wave motion in buried fluid-filled pipes. Furthermore, displacement profiles in spatial domain resulting from gas-dominated wave in buried gas pipeline systems will be analyzed, and the effects of pipe material, soil property, as well as mode wave type will be discussed in detail. An effective radiation coefficient (ERC) is proposed to measure the effective radiation ability of gas-dominated wave and water-dominated wave. It is observed that the gas-dominated wave in gas pipes cannot radiate into surrounded soil as effectively as water-dominated wave in water pipes because of the weak coupling between gas and pipe-soil. In this case, gas-dominated wave may not be the best choice as the target wave for locating buried gas pipes. Therefore, the soil displacements result from the shell-dominated wave are also investigated and compared with those from gas-dominated wave. The results show that for buried gas pipes, the soil displacements due to radiation of shell-dominated wave are stronger than gas-dominated wave, which differs from buried water pipe. Hence, an effectively exciting shell-dominated wave is beneficial for generating stronger vibration signals and obtaining the location information. The findings of this study provide theoretical insight for optimizing the current vibro-acoustic method when locating buried gas pipes

A comprehensive review of acoustic methods for locating underground pipelines

Underground pipelines are vital means of transporting fluid resources like water, oil and gas. The process of locating buried pipelines of interest is an essential prerequisite for pipeline maintenance and repair. Acoustic pipe localization methods, as effective trenchless detection techniques, have been implemented in locating underground utilities and shown to be very promising in plastic pipeline localization. This paper presents a comprehensive review of current acoustic methods and recent advances in the localization of buried pipelines. Investigations are conducted from multiple perspectives including the wave propagation mechanism in buried pipe systems, the principles behind each method along with advantages and limitations, representative acoustic locators in commercial markets, the condition of buried pipes, as well as selection of preferred methods for locating pipelines based on the applicability of existing localization techniques. In addition, the key features of each method are summarized and suggestions for future work are proposed. Acoustic methods for locating underground pipelines have proven to be useful and effective supplements to existing localization techniques. It has been highlighted that the ability of acoustic methods to locate non-metallic objects should be of particular practical value. While this paper focuses on a specific application associated with pipeline localization, many acoustic methods are feasible across a wide range of underground infrastructures

A Review of Static Pressure Reset Control in Variable Air Volume Air Condition System

AbstractFor the sake of energy saving of variable air volume (VAV) system, this paper presents the a review of static pressure control around the optimization problem of static pressure reset in VAV air conditioning system. Then, main control methods of static pressure reset are described, and existing problems are analyzed and concluded. Finally, it is pointed out that the critical technology and the development trend of static pressure reset control. This overview is not intended to be an exhaustive survey on this topic, and any omission of other works is purely unintentional

Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke

Ischemic stroke accounts for 70–80% of all stroke cases. Immunity plays an important role in the pathophysiology of ischemic stroke. Microglia are the first line of defense in the central nervous system. Microglial functions are largely dependent on their pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotype. Modulating neuroinflammation via targeting microglia polarization toward anti-inflammatory phenotype might be a novel treatment for ischemic stroke. Mesenchymal stem cells (MSC) and MSC-derived extracellular vesicles (MSC-EVs) have been demonstrated to modulate microglia activation and phenotype polarization. In this review, we summarize the physiological characteristics and functions of microglia in the healthy brain, the activation and polarization of microglia in stroke brain, the effects of MSC/MSC-EVs on the activation of MSC in vitro and in vivo, and possible underlying mechanisms, providing evidence for a possible novel therapeutics for the treatment of ischemic stroke

Photosynthetic adaptation strategies in peppers under continuous lighting: insights into photosystem protection

Energy efficient lighting strategies have received increased interest from controlled environment producers. Long photoperiods (up to 24 h - continuous lighting (CL)) of lower light intensities could be used to achieve the desired daily light integral (DLI) with lower installed light capacity/capital costs and low electricity costs in regions with low night electricity prices. However, plants grown under CL tend to have higher carbohydrate and reactive oxygen species (ROS) levels which may lead to leaf chlorosis and down-regulation of photosynthesis. We hypothesize that the use of dynamic CL using a spectral change and/or light intensity change between day and night can negate CL-injury. In this experiment we set out to assess the impact of CL on pepper plants by subjecting them to white light during the day and up to 150 µmol m-2 s-1 of monochromatic blue light at night while controlling the DLI at the same level. Plants grown under all CL treatments had similar cumulative fruit number and weight compared to the 16h control indicating no reduction in production. Plants grown under CL had higher carbohydrate levels and ROS-scavenging capacity than plants grown under the 16h control. Conversely, the amount of photosynthetic pigment decreased with increasing nighttime blue light intensity. The maximum quantum yield of photosystem II (Fv/Fm), a metric often used to measure stress, was unaffected by light treatments. However, when light-adapted, the operating efficiency of photosystem II (ΦPSII) decreased and non-photochemical quenching (NPQ) increased with increasing nighttime blue light intensity. This suggests that both acclimated and instantaneous photochemistry during CL can be altered and is dependent on the nighttime light intensity. Furthermore, light-adapted chlorophyll fluorescence measurements may be more adept at detecting altered photochemical states than the conventional stress metric using dark-adapted measurements

Rapid Determination of Active Ingredient Contents in Rhizoma Gastrodiae Using Near-Infrared Spectroscopy Combined with Artificial Rabbits Optimization-Least Square Support Vector Regression

In order to rapidly and non-destructively detect gastrodin and 4-hydroxybenzyl alcohol in Rhizoma Gastrodiae, near infrared spectral data of the dried tuber of Gastrodia elata Bl. f. glauca S. Chow were collected in the wavelength range of 900–1 700 nm. First, convolutional smoothing (SG) and standard normal variable transformation (SNV) were used for spectral data preprocessing. Second, feature wavelength extraction was carried out by competitive adaptive reweighted sampling (CARS) and iteratively retains informative variables (IRIV). According to the results of establishing least squares support vector machine (LSSVR) model based on feature wavelength, the best method of feature wavelength extraction was selected. In order to improve the accuracy of the model, this study introduced the artificial rabbits optimization (ARO) algorithm to optimize the regularization parameter γ and the kernel function density σ2 in LSSVR and the superiority of ARO to particle swarm optimization (PSO) and grey wolf optimizer (GWO) was evaluated. The results showed that the ARO algorithm was superior to PSO and GWO in in terms of optimization speed and ability. The best prediction models for gastrodin and 4-hydroxybenzyl alcohol were CARS-ARO-LSSVR, with prediction correlation coefficient (R2p) of 0.969 6 and 0.957 7, and root mean square error of prediction (RMSEP) of 0.014 and 0.020, respectively. Therefore, this study shows that near-infrared spectroscopy can be used for quantitative detection of active components in Rhizoma Gastrodiae, which provides a theoretical basis for the development of rapid detection devices for Rhizoma Gastrodiae

3% diquafosol sodium eye drops in Chinese patients with dry eye: a phase IV study

IntroductionThe efficacy and safety of 3% diquafosol sodium eye drops in Chinese patients with dry eye in the real-world setting remains unclear.Methods3099 patients with dry eye symptoms were screened according to Asia Dry Eye Society latest recommendation. Among them, 3000 patients were enrolled for a phase IV study. We followed up with multiple clinical characteristics including corneal fluorescein staining, tear break up time, Schirmer’s tests, visual acuity, intraocular pressure, and others. The follow ups were performed at baseline, 2 weeks and 4 weeks after treatment.ResultsBased on the results of corneal fluorescein staining and tear break up time, all age and gender subgroups exhibited obvious alleviation of the symptoms among the patients with dry eye, and the data in elderly group showed the most significant alleviation. All the adverse drug reactions (ADRs, 6.17%) were recorded, among which 6% local ocular ADRs were included. Meanwhile, mild ADRs (91.8%) accounted for the most. Most of the ADRs (89.75%) got a quick and full recovery, with an average time at 15.6 days. 1.37% of patients dropped out of the study due to ADRs.DiscussionThe use of 3% diquafosol sodium eye drop is effective and safe in the treatment of dry eye, with a low incidence of ADRs showing mild symptoms. This trial was registered at Chinese Clinical Trial Registry ID: ChiCTR1900021999 (Registration Date: 19/03/2019)

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly