Rapid Determination of Saponins in the Honey-Fried Processing of Rhizoma Cimicifugae by Near Infrared Diffuse Reflectance Spectroscopy.

ObjectiveA model of Near Infrared Diffuse Reflectance Spectroscopy (NIR-DRS) was established for the first time to determine the content of Shengmaxinside I in the honey-fried processing of Rhizoma Cimicifugae.MethodsShengmaxinside I content was determined by high-performance liquid chromatography (HPLC), and the data of the honey-fried processing of Rhizoma Cimicifugae samples from different batches of different origins by NIR-DRS were collected by TQ Analyst 8.0. Partial Least Squares (PLS) analysis was used to establish a near-infrared quantitative model.ResultsThe determination coefficient R² was 0.9878. The Cross-Validation Root Mean Square Error (RMSECV) was 0.0193%, validating the model with a validation set. The Root Mean Square Error of Prediction (RMSEP) was 0.1064%. The ratio of the standard deviation for the validation samples to the standard error of prediction (RPD) was 5.5130.ConclusionThis method is convenient and efficient, and the experimentally established model has good prediction ability, and can be used for the rapid determination of Shengmaxinside I content in the honey-fried processing of Rhizoma Cimicifugae

Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

Background. Herb-derived compound andrographolide sulfonate (called Xiyanping injection) recommended control measure for severe hand, foot, and mouth disease (HFMD) by the Ministry of Health (China) during the 2010 epidemic. However, there is a lack of good quality evidence directly comparing the efficacy of Andrographolide Sulfonate combination therapy with conventional therapy. Methods. 230 patients were randomly assigned to 7–10 days of Andrographolide Sulfonate 5–10 mg/Kg/day and conventional therapy, or conventional therapy alone. Results. The major complications occurred less often after Andrographolide Sulfonate (2.6% versus 12.1%; risk difference [RD], 0.94; 95% CI, 0.28–1.61; P=0.006). Median fever clearance times were 96 hours (CI, 80 to 126) for conventional therapy recipients and 48 hours (CI, 36 to 54) for Andrographolide Sulfonate combination-treated patients (χ2=16.57, P<0.001). The two groups did not differ in terms of HFMD-cause mortality (P=1.00) and duration of hospitalization (P=0.70). There was one death in conventional therapy group. No important adverse event was found in Andrographolide Sulfonate combination therapy group. Conclusions. The addition of Andrographolide Sulfonate to conventional therapy reduced the occurrence of major complications, fever clearance time, and the healing time of typical skin or oral mucosa lesions in children with severe HFMD

The missing base molecules in atmospheric acid-base nucleation

Forming an (H2SO4)(1)(amine)(1) cluster is the rate-limiting step in atmospheric H2SO4-amine nucleation, which governs the fast formation of new particles from gaseous precursors.Transformation of low-volatility gaseous precursors to new particles affects aerosol number concentration, cloud formation and hence the climate. The clustering of acid and base molecules is a major mechanism driving fast nucleation and initial growth of new particles in the atmosphere. However, the acid-base cluster composition, measured using state-of-the-art mass spectrometers, cannot explain the measured high formation rate of new particles. Here we present strong evidence for the existence of base molecules such as amines in the smallest atmospheric sulfuric acid clusters prior to their detection by mass spectrometers. We demonstrate that forming (H2SO4)(1)(amine)(1) is the rate-limiting step in atmospheric H2SO4-amine nucleation and the uptake of (H2SO4)(1)(amine)(1) is a major pathway for the initial growth of H2SO4 clusters. The proposed mechanism is very consistent with measured new particle formation in urban Beijing, in which dimethylamine is the key base for H2SO4 nucleation while other bases such as ammonia may contribute to the growth of larger clusters. Our findings further underline the fact that strong amines, even at low concentrations and when undetected in the smallest clusters, can be crucial to particle formation in the planetary boundary layer.Peer reviewe

Molecular epidemiology of measles viruses in China, 1995–2003

This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that all of the isolates belonged to genotype H1 except 3 isolates, which were genotype A. The nucleotide sequence and predicted amino acid homologies of the 294-genotype H1 strains were 94.7%–100% and 93.3%–100%, respectively. The genotype H1 isolates were divided into 2 clusters, which differed by approximately 2.9% at the nucleotide level. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Even though other measles genotypes have been detected in countries that border China, this report shows that genotype H1 is widely distributed throughout the country and that China has a single, endemic genotype. This important baseline data will help to monitor the progress of measles control in China

Hua yu shi ci shang xi /

Taiwan resource centre for Chinese studie

Local well-posedness for a two-phase model with magnetic field and vacuum

summary:This paper proves the local well-posedness of strong solutions to a two-phase model with magnetic field and vacuum in a bounded domain $\Omega \subset \mathbb {R}^3$ without the standard compatibility conditions

The complete mitochondrial genome of Pseudopimelodus schultzi Dahl 1955 (Siluriformes, Pseudopimelodidae) and its phylogenetic position within Pseudopimelodidae

The complete mitochondrial DNA genome of Pseudopimelodus schultzi was first was determined in this study. The entire length of mitochondrial genome consists of 13 protein-codinggenes (PCG), 2 ribosomal RNA genes (rRNA), and 22 transfer RNA (tRNA) genes and control region. The nucleotide composition was made up of 32.2% A, 25.9% T, 26.7% C, and 15.2% G, respectively, indicating an A + T (58.1%)-rich feature. With the exception of 8 tRNA genes and NADH6, mitochondrial genes are encoded on the heavy strand, which was similar to that in other vertebrates. The results showed that the species of Pseudopimelodidae were gathered in the same branch. The phylogenies indicate monophyly of the genus Batrochoglanis, Batrochoglanis and Microglanis, respectively

POSITIVITY-PRESERVING LOCAL DISCONTINUOUS GALERKIN METHOD FOR PATTERN FORMATION DYNAMICAL MODEL IN POLYMERIZING ACTIN FLOCKS\u3csup\u3e*\u3c/sup\u3e

In this paper, we apply local discontinuous Galerkin (LDG) methods for pattern formation dynamical model in polymerizing actin flocks. There are two main difficulties in designing effective numerical solvers. First of all, the density function is non-negative, and zero is an unstable equilibrium solution. Therefore, negative density values may yield blow-up solutions. To obtain positive numerical approximations, we apply the positivity-preserving (PP) techniques. Secondly, the model may contain stiff source. The most commonly used time integration for the PP technique is the strong-stability-preserving Runge-Kutta method. However, for problems with stiff source, such time discretizations may require strictly limited time step sizes, leading to large computational cost. Moreover, the stiff source any trigger spurious filament polarization, leading to wrong numerical approximations on coarse meshes. In this paper, we combine the PP LDG methods with the semi-implicit Runge-Kutta methods. Numerical experiments demonstrate that the proposed method can yield accurate numerical approximations with relatively large time steps

Modified triple pelvic osteotomy for adult symptomatic acetabular dysplasia: clinical and radiographic results at midterm follow-up

Abstract Background Acetabular dysplasia is the most common cause of secondary arthritis of the hip joint. Achieving maximum restoration of the acetabular coverage and medialization of the femoral head remains difficult with the original Steel triple pelvic osteotomy for acetabular dysplasia in children and adults. This study intended to answer the following questions: (1) Are the midterm functional results of our modified procedure favorable, particularly in relation to Harris scores? and (2) On the basis of the Tönnis grade, does this procedure has a different effect on radiographic parameters and functional results at midterm follow-up? Methods This study included 26 consecutive adult patients with symptomatic acetabular dysplasia (28 hips) who underwent modified triple pelvic osteotomy through two incisions between July 2005 and June 2012. According to the preoperative Tönnis grade, the patients were divided into T0 (Tönnis grade 0), T1 (Tönnis grade 1), and T2 (Tönnis grade 2) groups. Wiberg center-edge (CE) angle, Sharp acetabular angle, lateralization, and Harris scores were analyzed to assess the radiographic and clinical outcomes. Results The mean CE angle (28.43° [± 3.58°], p < 0.05), Sharp acetabular angle (36.39° [± 3.26°], p < 0.05), lateralization (16.82 mm [± 3.10 mm], p < 0.05), and Harris scores (89.07 [± 4.97], p < 0.05) at the last follow-up significantly improved compared to those preoperatively. Multiple comparisons of radiographic outcomes among the three groups indicated no significant difference (p < 0.05). Harris scores in group T2 were significantly lower than those in groups T0 (p < 0.05) and T1 (p < 0.05). No major complication was observed. Conclusions Our modified triple pelvic osteotomy for adult symptomatic acetabular dysplasia with early-stage osteoarthritis could lead to excellent radiographic outcomes, good clinical results, and lower complication rates

A local discontinuous Galerkin method for pattern formation dynamical model in polymerizing action flocks

In this paper, we apply local discontinuous Galerkin methods to the pattern formation dynamical model in polymerizing action flocks. Optimal error estimates for the density and filament polarization in different norms are established. We use a semi-implicit spectral deferred correction time method for time discretization, which allows a relative large time step and avoids computation of a Jacobian matrix. Numerical experiments are presented to verify the theoretical analysis and to show the capability for simulations of action wave formation