227 research outputs found

    PLASIM–GENIE v1.0: a new intermediate complexity AOGCM

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    We describe the development, tuning and climate of Planet Simulator (PLASIM)–Grid-ENabled Integrated Earth system model (GENIE), a new intermediate complexity Atmosphere–Ocean General Circulation Model (AOGCM), built by coupling the Planet Simulator to the ocean, sea-ice and land-surface components of the GENIE Earth system model. PLASIM–GENIE supersedes GENIE-2, a coupling of GENIE to the Reading Intermediate General Circulation Model (IGCM). The primitive-equation atmosphere includes chaotic, three-dimensional (3-D) motion and interactive radiation and clouds, and dominates the computational load compared to the relatively simpler frictional-geostrophic ocean, which neglects momentum advection. The model is most appropriate for long-timescale or large ensemble studies where numerical efficiency is prioritised, but lack of data necessitates an internally consistent, coupled calculation of both oceanic and atmospheric fields. A 1000-year simulation with PLASIM–GENIE requires approximately 2 weeks on a single node of a 2.1 GHz AMD 6172 CPU. We demonstrate the tractability of PLASIM–GENIE ensembles by deriving a subjective tuning of the model with a 50- member ensemble of 1000-year simulations. The simulated climate is presented considering (i) global fields of seasonal surface air temperature, precipitation, wind, solar and thermal radiation, with comparisons to reanalysis data; (ii) vegetation carbon, soil moisture and aridity index; and (iii) sea surface temperature, salinity and ocean circulation. Considering its resolution, PLASIM–GENIE reproduces the main features of the climate system well and demonstrates usefulness for a wide range of applications

    Optimization of Ultrahigh Pressure Assisted Micellar Extraction of Taxifolin from Larch

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    In this study, in order to simplify the extraction process of taxifolin, cut costs and energy sources, improve extraction efficiency, and promote comprehensive application of taxifolin. Taxifolin was extracted from the trunk of Larix gemlini by ultra-high pressure assisted micellar green solvent extraction technology, using Larix gemlini of Heilongjiang Province as raw material. Based on the total content of taxifolin in different parts of larch root and trunk, tea saponin was selected as the most appropriate surfactant from candidate surfactants. The extraction process was optimized by response surface experiment, investigating effects of solid-liquid ratio, extraction pressure, extraction times and micellar concentration on the extraction rate of taxifolin. Results showed that, the optimal extraction process conditions were selected as follows: The tea saponin concentration was 8%, the solid-liquid ratio was 1:11.5, the extraction pressure was 157 MPa, the extraction times were 3 times, the holding time was 5 min. The experiment was repeated for 3 times under the optimum condition, and the actual extraction rate of taxifolin was 84.35%±1.2%, which was basically consistent with the predicted value of 84.98%. Compared with different extraction processes such as microwave extraction, ultrasonic extraction and reflux extraction, the energy consumption and CO2 emission per unit of raw material of ultra-high pressure assisted micelle extraction were the lowest, which was 1.64×10−4 kW·h·g−1 and 1.29×10−4 kg/g respectively. To summarize, the extraction of taxifolin from larch by ultra-high pressure assisted micellar green solvent extraction technology could be used widely which was environmentally friendly, simple, stable, reasonable and reliable

    Association of blood pressure with development of metabolic syndrome components: a five-year retrospective cohort study in Beijing

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    Background: Raised blood pressure (BP) is associated with the incidence of metabolic syndrome (MetS). It is unknown if subjects with different BP levels may develop certain components of MetS over time. We investigated the incidence of MetS relative to different levels of BP over a 5-year period in a Chinese population in Tongren Hospital, Beijing. Methods: During the period of 2006–2011, we recruited 2,781 participants with no MetS, or self-reported type 2 diabetes, dyslipidemia, hypertension, or cardiovascular disease at baseline. Association rule was used to identify the transitions of MetS components over time. Results: The incidence of MetS at follow-up was 9.74% for men and 3.21% for women in the group with optimal BP; 10.29% and 7.22%, respectively, in the group with normal BP; 10.49% and 10.84%, respectively, in the group with high-normal BP; and 14.48% and 23.21%, respectively in the group with high BP. The most common transition was from healthy to healthy in the groups with optimal or normal BP (17.9–49.3%), whereas in the high-normal BP group, 16.9-22.1% of subjects with raised BP returned to healthy status or stayed unchanged, while 13.8-21.4% of people with high BP tended to develop raised fasting glucose levels. Conclusions: The incidence of MetS increased in parallel with the increase in BP. People with optimal and normal BP levels were less susceptible to developing MetS over time, whereas abnormal BP seemed to be a pre-existing phase of MetS. High-normal BP was a crucial status for MetS prevention

    Concentrations and gas-particle partitioning of PCDD/Fs in the urban air of Dalian, China

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    PCDD/Fs in the urban air of Dalian, China were monitored with high-volume active sampler from November 2009 to October 2010. The concentration of Cl4-8DD/Fs ranged from 3065 to 49538 fg m(-3), with an average of 10249 fg m(-3). The international toxic equivalents (I-TEQ) value of that was 61.8-1182 fg m(-3), with an average of 235 fg m(-3), which was comparable to those in the other urban locations around the world. It was found that the Cl4-8DD/Fs appeared to be present mainly in the particle phase during winter, spring and autumn, while during summer which were dominantly in gas phase. The ratio of Cl4-8DD/Fs present in particle phase increased with the increasing level of chlorination. The concentrations of PCDFs and PCDDs decreased with the increase of chlorinated level, while the concentrations of 2,3,7,8-PCDDs congeners increased with the increase of chlorination level. The homolog profiles of the concentrations of PCDFs presented were higher than those of the PCDDs, which indicated the PCDD/Fs pollution source of the air in Dalian was characteristic for thermal source pollution. The correlation analysis of meteorological parameters with the concentrations of Cl4-8CDD/Fs was conducted using SPSS packages, and it was found that the ambient temperature and atmospheric pressure were important factors influence the concentration of PCDD/Fs in the air. The respiratory risk and intake dioxins of the residents around the sampling sites were studied in the paper. It was found that Junge-Pankow model was much more accurate in predicting the gas-particle partitioning behavior of PCDD/Fs homologues during winter, while the Harner-Bidleman model shows better agreement with the measured data during winter and summer

    Association between γ-glutamyl transferase and metabolic syndrome: A cross-sectional study of an adult population in Beijing

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    The relationship between liver enzymes and clustered components of metabolic syndrome (MetS) is explored and the predictive power of γ-glutamyl transferase (GGT) for the diagnosis of MetS in an adult population in Beijing is investigated. A total of 10,553 adults aged 20-65 years who underwent health examinations at Beijing Tongren Hospital in 2012 were enrolled in the study. Multivariate logistic regression analysis is conducted to determine the associations between the levels of various liver enzymes and clustered components of MetS. A receiver operating characteristic analysis is used to determine the optimal cut-off value of GGT for the diagnosis of MetS. A high level of GGT is found to be positively associated with clustered components of MetS in both men and women after adjusting for age, body mass index (BMI), history of alcoholic fatty liver, and the presence of taking anti-hypertensive, anti-dyslipidemic, and anti-diabetic drugs. Among all components of MetS, GGT is more predictive of triglyceride, and BMI. The area-under-the-curve values of GGT for discriminating MetS from normal metabolic status in men and women are 0.73 and 0.80, respectively. The optimal cut-off value of GGT for men is 31.50 U/L, demonstrating a sensitivity of 74.00% and specificity of 62.00%. For women, it is 19.50 U/L (sensitivity 76.00% and specificity 70.00%). GGT is therefore recommended as a useful diagnostic marker for MetS, because the test is inexpensive, highly sensitive, and frequently encountered in clinical practice

    On the role of horizontal resolution over the Tibetan Plateau in the REMO regional climate model

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    A number of studies have shown that added value is obtained by increasing the horizontal resolution of a regional climate model to capture additional fine-scale weather processes. However, the mechanisms leading to this added value are different over areas with complicated orographic features, such as the Tibetan Plateau (TP). To determine the role that horizontal resolution plays over the TP, a detailed comparison was made between the results from the REMO regional climate model at resolutions of 25 and 50 km for the period 1980–2007. The model was driven at the lateral boundaries by the European Centre for Medium-Range Weather Forecasts Interim Reanalysis data. The experiments differ only in representation of topography, all other land parameters (e.g., vegetation characteristics, soil texture) are the same. The results show that the high-resolution topography affects the regional air circulation near the ground surface around the edge of the TP, which leads to a redistribution of the transport of atmospheric water vapor, especially over the Brahmaputra and Irrawaddy valleys—the main water vapor paths for the southern TP—increasing the amount of atmospheric water vapor transported onto the TP by about 5. This, in turn, significantly decreases the temperature at 2 m by > 1.5 °C in winter in the high-resolution simulation of the southern TP. The impact of topography on the 2 m temperature over the TP is therefore by influencing the transport of atmospheric water vapor in the main water vapor paths. © 2018 Springer-Verlag GmbH Germany, part of Springer Natur

    Combined evaluation of arterial stiffness and blood pressure promotes risk stratification of peripheral arterial disease

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    Background: Previous studies have reported the separate association of arterial stiffness (AS) and blood pressure with peripheral arterial disease (PAD). Objectives: The aim of this study was to investigate the risk stratification capacity of AS on incident PAD beyond blood pressure status. Methods: A total of 8,960 participants from Beijing Health Management Cohort were enrolled at the first health visit between 2008 and 2018 and then followed until the incidence of PAD or 2019. Elevated AS was defined as brachial-ankle pulse-wave velocity (baPWV) \u3e 1,400 cm/s, including moderate stiffness (1,400 ≤ baPWV \u3c 1,800 cm/s) and severe stiffness (baPWV ≥ 1,800 cm/s). PAD was defined as ankle-brachial index \u3c 0.9. A frailty Cox model was used to calculate the HR, integrated discrimination improvement, and net reclassification improvement. Results: During follow-up, 225 participants (2.5%) developed PAD. After adjusting for confounding factors, the highest risk for PAD was observed in the group with elevated AS and blood pressure (HR: 2.253; 95% CI: 1.472-3.448). Among participants with ideal blood pressure and those with well-controlled hypertension, PAD risk was still significant for severe AS. The results remained consistent in multiple sensitivity analyses. In addition, baPWV significantly improved the predictive capacity for PAD risk beyond systolic and diastolic blood pressures (integrated discrimination improvement 0.020 and 0.190, net reclassification improvement 0.037 and 0.303). Conclusions: This study suggests the clinical importance of combined evaluation and control of AS and blood pressure for the risk stratification and prevention of PAD
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