Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity

There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies

Mid-infrared Spectral Compression of Soliton Pulse in an Adiabatically Suspended Silicon Waveguide Taper

Spectral compression (SPC) can be used for generating narrow bandwidth and wavelength-tunable light sources, which have important applications in optical communication system, spectroscopy, and nonlinear microscopy. In this paper, we numerically demonstrate the high-degree SPC of the chirp-free femtosecond pulse at wavelength 2.4 μm in a 6-cm long adiabatically suspended silicon waveguide taper. The silicon waveguide taper is designed with a dispersion-increasing profile along the propagation distance z. Simulation results show that the SPC factor can be up to 10.9, along with the brightness-enhanced factor of 8.0 and negligible sidelobe. The impacts of the higher-order dispersion, higher-order nonlinearity, losses (including linear and nonlinear loss), and variation of Kerr nonlinear coefficient along z on the SPC are also investigated. It is found that variation of Kerr nonlinear coefficient γ(z) and linear loss are the dominant perturbation to the degradation of the SPC performance

Efficient spectral compression of wavelength-shifting soliton and its application in integratable all-optical quantization

In this paper, we numerically demonstrate efficient spectral compression (SPC) of wavelength-shifting soliton in a chalcogenide strip waveguide. It is found that the profiles of group-velocity dispersion (GVD) and Kerr nonlinearity play key roles in determining SPC. After calculating the dispersion of Kerr nonlinearity and Raman spectrum for three kinds of chalcogenide materials, Ge11.5As24Se64.5 is chosen as the material for designing the chalcogenide strip waveguide (CSW). The geometric parameters of CSW are optimized to obtain the desired GVD and Kerr nonlinearity. Simulation results show that in the designed CSW, an input spectrum width of 52.04 nm can be compressed to 7.23 nm along with wavelength shift of 17 nm when the input peak power is 25 W. With the input peak power increasing to 75 W, the SPC is slightly weakened, but wavelength shift can be up to 190 nm. The proposed CSW is applied to integrated all-optical quantization and an effective quantization number of 3.66-bit is achieved. It is expected that our research results can find important applications in on-chip integrated spectroscopy, all-optical signal processing, etc

Mid-infrared Self-Similar Pulse Compression in a Tapered Tellurite Photonic Crystal Fiber and Its Application in Supercontinuum Generation

In this paper, we design a tapered tellurite photonic crystal fiber (TTPCF) with nonlinear coefficient increasing along the propagation direction, and demonstrate the mid-infrared self-similar pulse compression of the fundamental soliton in such a TTPCF. When the variation of group-velocity dispersion, higher-order dispersion, higher-order nonlinearity, and linear loss are considered, a 1 ps pulse at wavelength 2.5 μm can be compressed to 62.16 fs after a 1.63-m long propagation, along with the negligible pedestal, compression factor Fc of 16.09, and quality factor Qc of 83.16%. Then the compressed pulse is launched into another uniform tellurite PCF designed, and highly coherent and octave-spanning supercontinuum (SC) is generated. Compared to the initial picosecond pulse, the compressed pulse has much larger tolerance of noise level for the SC generation. Our research results provide a promising solution to realize the fiber-based mid-infrared femtosecond pulse source for nonlinear photonics and spectroscopy

A Label-Free Fiber Ring Laser Biosensor For Ultrahigh Sensitivity Detection of Salmonella Typhimurium

The rapid detection of low concentrations of Salmonella Typhimurium (S. Typhimurium) is an essential preventive measure for food safety and prevention of foodborne illness. The study presented in this paper addresses this critical issue by proposing a single mode-tapered seven core-single mode (STSS) fiber ring laser (FRL) biosensor for S. Typhimurium detection. The experimental results show that the specific detection time of S. Typhimurium is less than 20 min and the wavelength shift can achieve -0.906 nm for an S. Typhimurium solution (10 cells/mL). Furthermore, at a lower concentration of 1 cell/mL applied to the biosensor, a result of -0.183 nm is observed in 9% of samples (1/11), which indicates that the proposed FRL biosensor has the ability to detect 1 cell/mL of S. Typhimurium. In addition, the detection results in chicken and pickled pork samples present an average deviation of -27% and -23%, respectively, from the measured results in phosphate buffered saline. Taken together, these results show the proposed FRL biosensor may have potential applications in the fields of food safety monitoring, medical diagnostics, etc

Mid-infrared octave-spanning supercontinuum and frequency comb generation in a suspended germanium-membrane ridge waveguide

Stable octave-spanning supercontinuum (SC) in the mid-infrared (MIR) region finds extensive applications in spectroscopy, metrology, biochemistry, etc. The absorption of conventional silicon- or silicon oxide-dominated nonlinear media makes SC generation in MIR region technically challenging. In this paper, we propose ultra-broadband MIR-SC generation using a suspended germanium-membrane ridge waveguide. We theoretically showed that when pump pulses centered at 4.8 um with pulse width at 180 fs and peak power at 800 W are injected into a 4-mm long proposed ridge waveguide, the SC generated ranges from 1.96 ~ 12 um (about 2.6 octaves), extending deep into the “fingerprint” region. The first-order coherence is calculated to confirm the stability of the generated SC. The performance of the SC-based frequency comb is also investigated by assuming a 100-pulses pump source at a repetition rate of 100 KHz

Mid-Infrared Self-Similar Pulse Compression in a Tapered Tellurite Photonic Crystal Fiber and Its Application in Supercontinuum Generation

In this paper, we design a tapered tellurite photonic crystal fiber (TTPCF) with nonlinear coefficient increasing along the propagation direction, and demonstrate the mid-infrared self-similar pulse compression of the fundamental soliton in such a TTPCF. When the variation of group-velocity dispersion, higher-order dispersion, higher-order nonlinearity, and linear loss are considered, a 1 ps pulse at wavelength 2.5 μm can be compressed to 62.16 fs after a 1.63-m long propagation, along with the negligible pedestal, compression factor Fc of 16.09, and quality factor Qc of 83.16%. Then the compressed pulse is launched into another uniform tellurite PCF, where highly coherent and octave-spanning supercontinuum (SC) is generated. Compared to the initial picosecond pulse, the compressed pulse has much larger tolerance of noise level for the SC generation. Our research results provide a promising solution to realize the fiber-based mid-infrared femtosecond pulse source for nonlinear photonics and spectroscopy