TELEX HEBDOMADAIRE NR 95 DU 17.09.82 DESTINE A L'ENSEMBLE DES DELEGATIONS EXTERIEURES ET BUREAUX DE PRESS ET D'INFORMATION INDEPENDANTS DANS LES PAYS TIERS = WEEKLY MEMO NO. 95 FOR 17.09.82 TO FOREIGN DELEGATIONS AND PRESS BUREAUS OF THIRD COUNTRIES

<p>High-performance liquid chromatography (HPLC) results of (A) commercial surfactin sample, and (B) our extract surfactin of <i>B</i>. <i>subtilis</i> HH2 in LB medium. There were three main peaks (Peak A-C) of the extract and the surfactin standard in the same location.</p

Additional file 1 of The efficacy and safety of micropulse transscleral laser treatment in glaucoma: a systematic review and meta-analysis

Supplementary Material

Additional file 3 of The efficacy and safety of micropulse transscleral laser treatment in glaucoma: a systematic review and meta-analysis

Supplement Figure 1. Meta-analysis of mTLT comparing to CW-TSCPC in baseline IOP. A total of 113 patients treated with mTLT and 225 patients treated with CW-TSCPC was included. The baseline IOP in CW-TSCPC group was higher than that in mTLT group (WMD=-0.31, 95% CI -0.55 to -0.08). Figure 2. Meta-analysis of post- and pre-operative NOAM in mTLT at various visits. A total of 103 patients treated with mTLT was included. The IOP significantly reduced at 1-2 weeks, 3, and 6 months (WMD=-0.35, 95% CI -0.66 to -0.04; WMD=-0.51, 95% CI -0.91 to -0.11; WMD=-0.59, 95% CI -0.77 to -0.22, respectively?after mTLT treatment. Figure 3. Meta-analysis of mTLT comparing to CW-TSCPC in baseline NOAM. A total of 103 patients treated with mTLT and 215 patients treated with CW-TSCPC was included. No significant difference was observed between these two modalities of laser treatment (WMD=-0.06, 95% CI -0.30 to 0.18). Figure 4. Filled funnel plot of NOAM before and after mTLT

Design of Functionalized Cellulosic Honeycomb Films: Site-Specific Biomolecule Modification via “Click Chemistry”

Value-added materials from naturally abundant polymers such as cellulose are of significant importance. In particular, cellulosic open-framework structures with controlled chemical functionality of the internal surface have great potential in many biosensor applications. Although various cellulose derivatives can form porous honeycomb structured materials, solubility issues and problems with film formation exist. To address this, we have generated robust cellulosic open-framework structures that can be post-functionalized through site-specific modification. Regioselectively modified amphiphilic cellulose azides, 3-<i>O</i>-azidopropoxypoly­(ethylene glycol)-2,6-di-<i>O</i>-thexyldimethylsilyl cellulosics, were synthesized, and honeycomb-patterned films were readily produced by the simple breath figures method. Changing the degree of polymerization (DP) of the pendent ethylene glycol (EG_DP) groups from 22 to 4 increased the corresponding honeycomb film pore diameters from ∼1.2 to ∼2.6 μm, enabling the potential tuning of pore size. Moreover, these novel azido-functionalized honeycomb films were easily functionalized using Cu­(I)-catalyzed alkyne–azide [2 + 3] cycloaddition reaction; biotin was “clicked” onto the azide functionalized cellulosic honeycomb films without any effect to the film structure. These results indicate this system may serve as a platform for the design and development of biosensors

Additional file 2 of The efficacy and safety of micropulse transscleral laser treatment in glaucoma: a systematic review and meta-analysis

Supplementary Material

Inorganic nitrogen (N) (A) and dissolved organic N (B) across different sites in summer and winter.

<p>Results are presented as mean ± stander error. Support information is presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092985#pone.0092985.s001" target="_blank">Table S1</a>.</p

Cardiovascular effects of dipeptidyl peptidase-4 inhibitor in diabetic patients with and without established cardiovascular disease: a meta-analysis and systematic review

<p><b>Objectives</b>: We aim to conduct a meta-analysis, by stratifying diabetic patients with or without clinical cardiovascular diseases (CVD), to explore whether there are different cardiovascular effects of dipeptidyl peptidase-4 inhibitors (DPP-4is) on these two different classes of diabetic patients.</p> <p><b>Methods</b>: We searchedMedline,Embase, theCochrane Libraryand ClinicalTrials.gov for relevant randomized controlled trials (RCTs). The included trials are divided into CVD (+) trials (subjects with established CVD), and CVD (-) trials (subjects with no CVD). We use all-cause mortality and cardiovascular outcomes as primary endpoints.</p> <p><b>Results</b>: (1) Three CVD (+) trials were included and 36,895 subjects were enrolled with a mean follow-up duration of 127.1 weeks. The pooled results showed that DPP-4is treatment, compared with the placebo, did not significantly affect all-cause mortality (RR, 1.03; 95% CI, 0.95 to 1.11), cardiovascular death (1.01, 0.91 to 1.12), myocardial infarction (0.98, 0.88 to 1.08) or stroke (1.02, 0.88 to 1.18) in diabetic patients with coexisting CVD history; however, it significantly increased the risk of heart failure (1.14, 1.01 to 1.27) in this population. 2) Thirty-five CVD (-) trials were included, and 29,600 patients were enrolled with a mean follow-up duration of 77.8 weeks. The analysis comparing DPP-4is with the placebo control showed that DPP-4is treatment did not significantly affect the risk of all-cause mortality or cardiovascular outcomes in diabetic patients free of CVD history. However, when compared with the active control, the pooling data showed that DPP-4is had a significant reduction on the risk of stroke (0.58, 0.34 to 0.99) but did not significantly affect the risk of all-cause mortality and other cardiovascular outcomes.</p> <p><b>Conclusion</b>: DPP-4is may have no cardiovascular protective effects in diabetic patients with coexisting CVD, while there is a lack of definitive evidence supporting the cardiovascular benefits of DPP-4is treatment among diabetic patients free of CVD history.</p

The repeated measure ANOVA results of soil and microbial properties tested in this study.

<p>IN  =  inorganic nitrogen; DON  =  dissolved organic nitrogen; MB  =  microbial biomass; G−/G+  =  gram negative to positive bacteria biomass ratio; SOCMR  =  soil organic carbon mineralization rate.</p

The distribution of sampling sites.

<p>P1  =  ∼15-year Mongolia pine; P2  =  ∼25-year Mongolia pine; P3  =  ∼35-year Mongolia pine; L1  =  ∼15-year Prince Rupprecht's larch; L2  =  ∼25-year larch; L3  =  ∼35-year larch; BH  =  Birch; MA  =  Siberian crabapple; RO  =  Solitary rose; CG  =  Meadow grassland.</p

Potential carbon mineralization rates across different sites in summer and winter.

<p>Results are presented as mean ± standard error. Support information is presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092985#pone.0092985.s001" target="_blank">Table S1</a>.</p