346 research outputs found

    SOX Genes and Cancer

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    Transcription factors play a critical role in regulating the gene expression programs that establish and maintain specific cell states in humans. Deregulation of these gene expression programs can lead to a broad range of diseases including cancer. SOX transcription factors are a conserved group of transcriptional regulators that mediates DNA binding by a highly conserved high-mobility group (HMG) domain. Numerous evidence has recently demonstrated that SOX transcription factors critically control cell fate and differentiation in major developmental processes, and that their upregulation may be important for cancer progression. In this review, we discuss recent advances in our understanding of the role of SOX genes in cancer

    3DFill:Reference-guided Image Inpainting by Self-supervised 3D Image Alignment

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    Most existing image inpainting algorithms are based on a single view, struggling with large holes or the holes containing complicated scenes. Some reference-guided algorithms fill the hole by referring to another viewpoint image and use 2D image alignment. Due to the camera imaging process, simple 2D transformation is difficult to achieve a satisfactory result. In this paper, we propose 3DFill, a simple and efficient method for reference-guided image inpainting. Given a target image with arbitrary hole regions and a reference image from another viewpoint, the 3DFill first aligns the two images by a two-stage method: 3D projection + 2D transformation, which has better results than 2D image alignment. The 3D projection is an overall alignment between images and the 2D transformation is a local alignment focused on the hole region. The entire process of image alignment is self-supervised. We then fill the hole in the target image with the contents of the aligned image. Finally, we use a conditional generation network to refine the filled image to obtain the inpainting result. 3DFill achieves state-of-the-art performance on image inpainting across a variety of wide view shifts and has a faster inference speed than other inpainting models

    Strong Variational Sufficiency for Nonlinear Semidefinite Programming and its Implications

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    Strong variational sufficiency is a newly proposed property, which turns out to be of great use in the convergence analysis of multiplier methods. However, what this property implies for non-polyhedral problems remains a puzzle. In this paper, we prove the equivalence between the strong variational sufficiency and the strong second order sufficient condition (SOSC) for nonlinear semidefinite programming (NLSDP), without requiring the uniqueness of multiplier or any other constraint qualifications. Based on this characterization, the local convergence property of the augmented Lagrangian method (ALM) for NLSDP can be established under strong SOSC in the absence of constraint qualifications. Moreover, under the strong SOSC, we can apply the semi-smooth Newton method to solve the ALM subproblems of NLSDP as the positive definiteness of the generalized Hessian of augmented Lagrangian function is satisfied.Comment: 23 page

    Audio Visual Speaker Localization from EgoCentric Views

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    The use of audio and visual modality for speaker localization has been well studied in the literature by exploiting their complementary characteristics. However, most previous works employ the setting of static sensors mounted at fixed positions. Unlike them, in this work, we explore the ego-centric setting, where the heterogeneous sensors are embodied and could be moving with a human to facilitate speaker localization. Compared to the static scenario, the ego-centric setting is more realistic for smart-home applications e.g., a service robot. However, this also brings new challenges such as blurred images, frequent speaker disappearance from the field of view of the wearer, and occlusions. In this paper, we study egocentric audio-visual speaker DOA estimation and deal with the challenges mentioned above. Specifically, we propose a transformer-based audio-visual fusion method to estimate the relative DOA of the speaker to the wearer, and design a training strategy to mitigate the problem of the speaker disappearing from the camera's view. We also develop a new dataset for simulating the out-of-view scenarios, by creating a scene with a camera wearer walking around while a speaker is moving at the same time. The experimental results show that our proposed method offers promising performance in this new dataset in terms of tracking accuracy. Finally, we adapt the proposed method for the multi-speaker scenario. Experiments on EasyCom show the effectiveness of the proposed model for multiple speakers in real scenarios, which achieves state-of-the-art results in the sphere active speaker detection task and the wearer activity prediction task. The simulated dataset and related code are available at https://github.com/KawhiZhao/Egocentric-Audio-Visual-Speaker-Localization

    An Accelerated Proximal Alternating Direction Method of Multipliers for Optimal Decentralized Control of Uncertain Systems

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    To ensure the system stability of the H2\bf{\mathcal{H}_{2}}-guaranteed cost optimal decentralized control problem (ODC), an approximate semidefinite programming (SDP) problem is formulated based on the sparsity of the gain matrix of the decentralized controller. To reduce data storage and improve computational efficiency, the SDP problem is vectorized into a conic programming (CP) problem using the Kronecker product. Then, a proximal alternating direction method of multipliers (PADMM) is proposed to solve the dual of the resulted CP. By linking the (generalized) PADMM with the (relaxed) proximal point algorithm, we are able to accelerate the proposed PADMM via the Halpern fixed-point iterative scheme. This results in a fast convergence rate for the Karush-Kuhn-Tucker (KKT) residual along the sequence generated by the accelerated algorithm. Numerical experiments further demonstrate that the accelerated PADMM outperforms both the well-known CVXOPT and SCS algorithms for solving the large-scale CP problems arising from H2\bf{\mathcal{H}_{2}}-guaranteed cost ODC problems
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