161 research outputs found
Reliability Evaluation for the Running State of the Manufacturing System Based on Poor Information
The output performance of the manufacturing system has a direct impact on the mechanical product quality. For guaranteeing product quality and production cost, many firms try to research the crucial issues on reliability of the manufacturing system with small sample data, to evaluate whether the manufacturing system is capable or not. The existing reliability methods depend on a known probability distribution or vast test data. However, the population performances of complex systems become uncertain as processing time; namely, their probability distributions are unknown, if the existing methods are still taken into account; it is ineffective. This paper proposes a novel evaluation method based on poor information to settle the problems of reliability of the running state of a manufacturing system under the condition of small sample sizes with a known or unknown probability distribution. Via grey bootstrap method, maximum entropy principle, and Poisson process, the experimental investigation on reliability evaluation for the running state of the manufacturing system shows that, under the best confidence level P=0.95, if the reliability degree of achieving running quality is r>0.65, the intersection area between the inspection data and the intrinsic data is A(T)>0.3 and the variation probability of the inspection data is PB(T)≤0.7, and the running state of the manufacturing system is reliable; otherwise, it is not reliable. And the sensitivity analysis regarding the size of the samples can show that the size of the samples has no effect on the evaluation results obtained by the evaluation method. The evaluation method proposed provides the scientific decision and suggestion for judging the running state of the manufacturing system reasonably, which is efficient, profitable, and organized
When Brain-inspired AI Meets AGI
Artificial General Intelligence (AGI) has been a long-standing goal of
humanity, with the aim of creating machines capable of performing any
intellectual task that humans can do. To achieve this, AGI researchers draw
inspiration from the human brain and seek to replicate its principles in
intelligent machines. Brain-inspired artificial intelligence is a field that
has emerged from this endeavor, combining insights from neuroscience,
psychology, and computer science to develop more efficient and powerful AI
systems. In this article, we provide a comprehensive overview of brain-inspired
AI from the perspective of AGI. We begin with the current progress in
brain-inspired AI and its extensive connection with AGI. We then cover the
important characteristics for both human intelligence and AGI (e.g., scaling,
multimodality, and reasoning). We discuss important technologies toward
achieving AGI in current AI systems, such as in-context learning and prompt
tuning. We also investigate the evolution of AGI systems from both algorithmic
and infrastructural perspectives. Finally, we explore the limitations and
future of AGI
Fine-Granularity Functional Interaction Signatures for Characterization of Brain Conditions
In the human brain, functional activity occurs at multiple spatial scales. Current studies on functional brain networks and their alterations in brain diseases via resting-state functional magnetic resonance imaging (rs-fMRI) are generally either at local scale (regionally confined analysis and inter-regional functional connectivity analysis) or at global scale (graph theoretic analysis). In contrast, inferring functional interaction at fine-granularity sub-network scale has not been adequately explored yet. Here our hypothesis is that functional interaction measured at fine-granularity subnetwork scale can provide new insight into the neural mechanisms of neurological and psychological conditions, thus offering complementary information for healthy and diseased population classification. In this paper, we derived fine-granularity functional interaction (FGFI) signatures in subjects with Mild Cognitive Impairment (MCI) and Schizophrenia by diffusion tensor imaging (DTI) and rsfMRI, and used patient-control classification experiments to evaluate the distinctiveness of the derived FGFI features. Our experimental results have shown that the FGFI features alone can achieve comparable classification performance compared with the commonly used inter-regional connectivity features. However, the classification performance can be substantially improved when FGFI features and inter-regional connectivity features are integrated, suggesting the complementary information achieved from the FGFI signatures
Anatomy-Guided Dense Individualized and Common Connectivity-Based Cortical Landmarks (A-DICCCOL)
Establishment of structural and functional correspondences of human brain that can be quantitatively encoded and reproduced across different subjects and populations is one of the key issues in brain mapping. As an attempt to address this challenge, our recently developed Dense Individualized and Common Connectivity-based Cortical Landmarks (DICCCOL) system reported 358 connectional landmarks, each of which possesses consistent DTI-derived white matter fiber connection pattern that is reproducible in over 240 healthy brains. However, the DICCCOL system can be substantially improved by integrating anatomical and morphological information during landmark initialization and optimization procedures. In this paper, we present a novel anatomy-guided landmark discovery framework that defines and optimizes landmarks via integrating rich anatomical, morphological, and fiber connectional information for landmark initialization, group-wise optimization and prediction, which are formulated and solved as an energy minimization problem. The framework finally determined 555 consistent connectional landmarks. Validation studies demonstrated that the 555 landmarks are reproducible, predictable, and exhibited reasonably accurate anatomical, connectional, and functional correspondences across individuals and populations and thus are named anatomy-guided DICCCOL or A-DICCCOL. This A-DICCCOL system represents common cortical architectures with anatomical, connectional, and functional correspondences across different subjects and would potentially provide opportunities for various applications in brain science
ChatRadio-Valuer: A Chat Large Language Model for Generalizable Radiology Report Generation Based on Multi-institution and Multi-system Data
Radiology report generation, as a key step in medical image analysis, is
critical to the quantitative analysis of clinically informed decision-making
levels. However, complex and diverse radiology reports with cross-source
heterogeneity pose a huge generalizability challenge to the current methods
under massive data volume, mainly because the style and normativity of
radiology reports are obviously distinctive among institutions, body regions
inspected and radiologists. Recently, the advent of large language models (LLM)
offers great potential for recognizing signs of health conditions. To resolve
the above problem, we collaborate with the Second Xiangya Hospital in China and
propose ChatRadio-Valuer based on the LLM, a tailored model for automatic
radiology report generation that learns generalizable representations and
provides a basis pattern for model adaptation in sophisticated analysts' cases.
Specifically, ChatRadio-Valuer is trained based on the radiology reports from a
single institution by means of supervised fine-tuning, and then adapted to
disease diagnosis tasks for human multi-system evaluation (i.e., chest,
abdomen, muscle-skeleton, head, and maxillofacial neck) from six different
institutions in clinical-level events. The clinical dataset utilized in this
study encompasses a remarkable total of \textbf{332,673} observations. From the
comprehensive results on engineering indicators, clinical efficacy and
deployment cost metrics, it can be shown that ChatRadio-Valuer consistently
outperforms state-of-the-art models, especially ChatGPT (GPT-3.5-Turbo) and
GPT-4 et al., in terms of the diseases diagnosis from radiology reports.
ChatRadio-Valuer provides an effective avenue to boost model generalization
performance and alleviate the annotation workload of experts to enable the
promotion of clinical AI applications in radiology reports
SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus
Abstract: Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated viral replication by enhancing viral M mRNA splicing. Mechanistically, SRSF5 with its RRM2 domain directly bounds M mRNA at conserved sites (M mRNA position 163, 709, and 712), and interacts with U1 small nuclear ribonucleoprotein (snRNP) to promote M mRNA splicing and M2 production. Mutations introduced to the three binding sites, without changing amino acid code, significantly attenuates virus replication and pathogenesis in vivo. Likewise, SRSF5 conditional knockout in the lung protects mice against lethal IAV challenge. Furthermore, anidulafungin, an approved antifungal drug, is identified as an inhibitor of SRSF5 that effectively blocks IAV replication in vitro and in vivo. In conclusion, SRSF5 as an activator of M mRNA splicing promotes IAV replication and is a host‐derived antiviral target
SY18ΔL60L: a new recombinant live attenuated African swine fever virus with protection against homologous challenge
IntroductionAfrican swine fever (ASF) is an acute and highly contagious disease and its pathogen, the African swine fever virus (ASFV), threatens the global pig industry. At present, management of ASF epidemic mainly relies on biological prevention and control methods. Moreover, due to the large genome of ASFV, only half of its genes have been characterized in terms of function.MethodsHere, we evaluated a previously uncharacterized viral gene, L60L. To assess the function of this gene, we constructed a deletion strain (SY18ΔL60L) by knocking out the L60L gene of the SY18 strain. To evaluate the growth characteristics and safety of the SY18ΔL60L, experiments were conducted on primary macrophages and pigs, respectively.ResultsThe results revealed that the growth trend of the recombinant strain was slower than that of the parent strain in vitro. Additionally, 3/5 (60%) pigs intramuscularly immunized with a 105 50% tissue culture infectious dose (TCID50) of SY18ΔL60L survived the 21-day observation period. The surviving pigs were able to protect against the homologous lethal strain SY18 and survive. Importantly, there were no obvious clinical symptoms or viremia.DiscussionThese results suggest that L60L could serve as a virulence- and replication-related gene. Moreover, the SY18ΔL60L strain represents a new recombinant live-attenuated ASFV that can be employed in the development of additional candidate vaccine strains and in the elucidation of the mechanisms associated with ASF infection
DICCCOL: Dense Individualized and Common Connectivity-Based Cortical Landmarks
Is there a common structural and functional cortical architecture that can be quantitatively encoded and precisely reproduced across individuals and populations? This question is still largely unanswered due to the vast complexity, variability, and nonlinearity of the cerebral cortex. Here, we hypothesize that the common cortical architecture can be effectively represented by group-wise consistent structural fiber connections and take a novel data-driven approach to explore the cortical architecture. We report a dense and consistent map of 358 cortical landmarks, named Dense Individualized and Common Connectivity–based Cortical Landmarks (DICCCOLs). Each DICCCOL is defined by group-wise consistent white-matter fiber connection patterns derived from diffusion tensor imaging (DTI) data. Our results have shown that these 358 landmarks are remarkably reproducible over more than one hundred human brains and possess accurate intrinsically established structural and functional cross-subject correspondences validated by large-scale functional magnetic resonance imaging data. In particular, these 358 cortical landmarks can be accurately and efficiently predicted in a new single brain with DTI data. Thus, this set of 358 DICCCOL landmarks comprehensively encodes the common structural and functional cortical architectures, providing opportunities for many applications in brain science including mapping human brain connectomes, as demonstrated in this work
Axonal Fiber Terminations Concentrate on Gyri
Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high–angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding
Investigation of Start Block and Corresponding Influence for Grain Selection during Casting of Single-Crystal Superalloys
To figure out the impact of the parameters of a starter block (the diameter D and height H) on grain selection and the selecting mechanism, a spiral selector was measured with optical microscopy (OM) and electron backscatter diffraction (EBSD) during the solidification of Ni-based single crystal (SX) superalloys. In this experiment, starter blocks with diameters of 8 mm, 10 mm, 15 mm, and 30 mm and a height of 30 mm were designed to find the best parameters. Recommendations for optimizing starter block geometry are provided
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