Outage Performance and Optimal Design of MIMO-NOMA Enhanced Small Cell Networks With Imperfect Channel-State Information

This paper focuses on boosting the performance of small cell networks (SCNs) by integrating multiple-input multiple-output (MIMO) and non-orthogonal multiple access (NOMA) in consideration of imperfect channel-state information (CSI). The estimation error and the spatial randomness of base stations (BSs) are characterized by using Kronecker model and Poisson point process (PPP), respectively. The outage probabilities of MIMO-NOMA enhanced SCNs are first derived in closed-form by taking into account two grouping policies, including random grouping and distance-based grouping. It is revealed that the average outage probabilities are irrelevant to the intensity of BSs in the interference-limited regime, while the outage performance deteriorates if the intensity is sufficiently low. Besides, as the channel uncertainty lessens, the asymptotic analyses manifest that the target rates must be restricted up to a bound to achieve an arbitrarily low outage probability in the absence of the inter-cell interference.Moreover, highly correlated estimation error ameliorates the outage performance under a low quality of CSI, otherwise it behaves oppositely. Afterwards, the goodput is maximized by choosing appropriate precoding matrix, receiver filters and transmission rates. In the end, the numerical results verify our analysis and corroborate the superiority of our proposed algorithm

CMDAG: A Chinese Metaphor Dataset with Annotated Grounds as CoT for Boosting Metaphor Generation

Metaphor is a prominent linguistic device in human language and literature, as they add color, imagery, and emphasis to enhance effective communication. This paper introduces a large-scale high quality annotated Chinese Metaphor Corpus, which comprises around 28K sentences drawn from a diverse range of Chinese literary sources, such as poems, prose, song lyrics, etc. To ensure the accuracy and consistency of our annotations, we introduce a comprehensive set of guidelines. These guidelines address the facets of metaphor annotation, including identifying tenors, vehicles, and grounds to handling the complexities of similes, personifications, juxtapositions, and hyperboles. Breaking tradition, our approach to metaphor generation emphasizes grounds and their distinct features rather than the conventional combination of tenors and vehicles. By integrating "ground" as a CoT (Chain of Thoughts) input, we are able to generate metaphors that resonate more with real-world intuition. We test generative models such as Belle, Baichuan, and Chinese-alpaca-33B using our annotated corpus. These models are able to generate creative and fluent metaphor sentences more frequently induced by selected samples from our dataset, demonstrating the value of our corpus for Chinese metaphor research. The code is available in https://github.com/JasonShao55/Chinese_Metaphor_Explanation

Reconstruction of Typhoon Structure Using 3-Dimensional Doppler Radar Radial Velocity Data with the Multigrid Analysis: A Case Study in an Idealized Simulation Context

Extracting multiple-scale observational information is critical for accurately reconstructing the structure of mesoscale circulation systems such as typhoon. The Space and Time Mesoscale Analysis System (STMAS) with multigrid data assimilation developed in Earth System Research Laboratory (ESRL) in National Oceanic and Atmospheric Administration (NOAA) has addressed this issue. Previous studies have shown the capability of STMAS to retrieve multiscale information in 2-dimensional Doppler radar radial velocity observations. This study explores the application of 3-dimensional (3D) Doppler radar radial velocities with STMAS for reconstructing a 3D typhoon structure. As for the first step, here, we use an idealized simulation framework. A two-scale simulated “typhoon” field is constructed and referred to as “truth,” from which randomly distributed conventional wind data and 3D Doppler radar radial wind data are generated. These data are used to reconstruct the synthetic 3D “typhoon” structure by the STMAS and the traditional 3D variational (3D-Var) analysis. The degree by which the “truth” 3D typhoon structure is recovered is an assessment of the impact of the data type or analysis scheme being evaluated. We also examine the effects of weak constraint and strong constraint on STMAS analyses. Results show that while the STMAS is superior to the traditional 3D-Var for reconstructing the 3D typhoon structure, the strong constraint STMAS can produce better analyses on both horizontal and vertical velocities

Pax3/7BP Is a Pax7- and Pax3-Binding Protein that Regulates the Proliferation of Muscle Precursor Cells by an Epigenetic Mechanism

SummaryIn mouse skeletal muscles, Pax7 uniquely marks muscle satellite cells and plays some important yet unknown functions at the perinatal stage. To elucidate its in vivo functions, we initiated a yeast two-hybrid screening to look for Pax7-interacting proteins and identified a previously uncharacterized Pax7- and Pax3-binding protein (Pax3/7BP). Pax3/7BP is a ubiquitously expressed nuclear protein, enriched in Pax7+ muscle precursor cells (MPCs), and serves as an indispensable adaptor for Pax7 to recruit the histone 3 lysine 4 (H3K4) methyltransferase (HMT) complex by bridging Pax7 and Wdr5. Knockdown of Pax3/7BP abolished the Pax3/7-associated H3K4 HMT activity and inhibited the proliferation of Pax7+ MPCs from young mice both in culture and in vivo. Id3 and Cdc20 were direct target genes of Pax7 and Pax3/7BP involved in the proliferation of Pax7+ MPCs. Collectively, our work establishes Pax3/7BP as an essential adaptor linking Pax3/7 with the H3K4 HMT to regulate the proliferation of MPCs

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy in which vision loss is caused by loss of retinal ganglion cells (RGCs). To better define the pathways mediating RGC death and identify targets for the development of neuroprotective drugs, we developed a high-throughput RNA interference screen with primary RGCs and used it to screen the full mouse kinome. The screen identified dual leucine zipper kinase (DLK) as a key neuroprotective target in RGCs. In cultured RGCs, DLK signaling is both necessary and sufficient for cell death. DLK undergoes robust posttranscriptional up-regulation in response to axonal injury in vitro and in vivo. Using a conditional knockout approach, we confirmed that DLK is required for RGC JNK activation and cell death in a rodent model of optic neuropathy. In addition, tozasertib, a small molecule protein kinase inhibitor with activity against DLK, protects RGCs from cell death in rodent glaucoma and traumatic optic neuropathy models. Together, our results establish a previously undescribed drug/drug target combination in glaucoma, identify an early marker of RGC injury, and provide a starting point for the development of more specific neuroprotective DLK inhibitors for the treatment of glaucoma, nonglaucomatous forms of optic neuropathy, and perhaps other CNS neurodegenerations

TRAF6 Promotes Myogenic Differentiation via the TAK1/p38 Mitogen-Activated Protein Kinase and Akt Pathways

p38 mitogen-activated protein kinase (MAPK) is an essential kinase involved in myogenic differentiation. Although many substrates of p38 MAPK have been identified, little is known about its upstream activators during myogenic differentiation. TRAF6 is known to function in cytokine signaling during inflammatory responses. However, not much is known about its role in myogenic differentiation and muscle regeneration. We showed here that TRAF6 and its intrinsic ubiquitin E3 ligase activity are required for myogenic differentiation. In mouse myoblasts, knockdown of TRAF6 compromised the p38 MAPK and Akt pathways, while deliberate activation of either pathway rescued the differentiation defect caused by TRAF6 knockdown. TAK1 acted as a key signal transducer downstream of TRAF6 in myogenic differentiation. In vivo, knockdown of TRAF6 in mouse muscles compromised the injury-induced muscle regeneration without impairing macrophage infiltration and myoblast proliferation. Collectively, we demonstrated that TRAF6 promotes myogenic differentiation and muscle regeneration via the TAK1/p38 MAPK and Akt pathways

Serum vitamin levels in multiple system atrophy: A case-control study

AimThere is increasing evidence suggesting that vitamins may play important roles in the pathogenesis of multiple system atrophy (MSA). The purpose of this study was to detect the changes of serum vitamin levels and investigate their correlation with disease severity in MSA patients.MethodsIn this cross-sectional study, 244 MSA patients, 200 Parkinson’s disease (PD) patients and 244 age-gender matched healthy controls were recruited. Serum vitamin levels were measured, including vitamin A, B1, B2, B9 (folate), B12, C, D, and E. Relevant clinical scales were used to assess the disease severity of MSA patients.ResultsCompared with the healthy controls, decreased serum folate levels and increased serum vitamin A and C levels were detected in MSA patients. Similar differences were also observed in the gender-based subgroup analysis. There were no differences detected between MSA and PD patients. In MSA patients, significant correlation was found between vitamin A, folate, or vitamin C and relevant clinical scales or laboratory findings. In addition, ROC analysis showed potential diagnostic value of the combination of vitamin A, folate, and vitamin C in distinguishing MSA patients from healthy controls.ConclusionThere were significant changes in the blood vitamin spectrums of MSA patients, suggesting that dysregulation of vitamins homeostasis might play an important role in the pathogenesis of MSA

Conjuntos excepcionais e alguns problemas de Mahler

Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Exatas, Departamento de Matemática, 2017.Seja f uma função inteira e transcendente. Denotamos por Sf o conjunto de todos os α ∈ ´Q tais que f(α) ∈ ´Q (o conjunto excepcional de f). Nessa dissertação, mostraremos quais subconjuntos de ´Q podem ser o conjunto excepcional de alguma função inteira e transcendente. Além disso, trataremos de dois problemas de Mahler relacionados a propriedades de funções inteiras e transcendentes. Mostraremos que existem funções inteiras e transcendentes que levam um subconjunto dos números de Liouville nele mesmo e daremos uma resposta positiva ao Problema B de Mahler: Problema B: Existe uma função inteira e transcendente f(z) = Σn =0 ∞ a nz n com coeficientes racionais tal que f( ´Q ) ⊆ ´Q e f−1( ´Q ) ⊆ ´Q ? .Let f be an entire transcendental function. We denote by Sf the set of all α ∈ ´Q such that f(α) ∈ ´Q (exceptional set of f). Throughout this dissertation, we will show which subsets of ´Q can be the exceptional set of some entire transcendental function. Moreover, we will deal with two of Mahler’s problems related to properties of entire transcendental functions. We will show that there are entire transcendental functions that map a subset of Liouville numbers in itself and we will give a positive answer for Mahler’s Problem B: Problem B: Is there an entire transcendental function f(z) = Σn =0 ∞ a nz n with rational coefficients such that que f( ´Q ) ⊆ ´Q e f−1( ´Q ) ⊆ ´Q ?