Analysis of Long Noncoding RNAs in Aila-Induced Non-Small Cell Lung Cancer Inhibition

Non-small cell lung cancer (NSCLC) has the highest morbidity and mortality among all carcinomas. However, it is difficult to diagnose in the early stage, and current therapeutic efficacy is not ideal. Although numerous studies have revealed that Ailanthone (Aila), a natural product, can inhibit multiple cancers by reducing cell proliferation and invasion and inducing apoptosis, the mechanism by which Aila represses NSCLC progression in a time-dependent manner remains unclear. In this study, we observed that most long noncoding RNAs (lncRNAs) were either notably up- or downregulated in NSCLC cells after treatment with Aila. Moreover, alterations in lncRNA expression induced by Aila were crucial for the initiation and metastasis of NSCLC. Furthermore, in our research, expression of DUXAP8 was significantly downregulated in NSCLC cells after treatment with Aila and regulated expression levels of EGR1. In conclusion, our findings demonstrate that Aila is a potent natural suppressor of NSCLC by modulating expression of DUXAP8 and EGR1

Design of Distributed Traceability System for Wheat Products Quality

Part 1: Decision Support Systems, Intelligent Systems and Artificial Intelligence ApplicationsInternational audienceThe circulation of wheat products involves a number of different types of food-related enterprises, including planting bases, grain trading companies, warehousing enterprises, food processing plants, sales companies and so on. The centralized traceability architecture cannot meet the requirements such as transaction data security. While, the distributed traceability architecture faces the difficulty and complexity of information processing for the traceability data stored and managed by different enterprises. In order to meet the requirements imposed on distributed data management and diversity of deployment requirements, an EPC (Electronic Product Code) coding scheme is proposed, in addition, based on which we design and implement a distributed wheat products quality traceability system in this paper. The test indicates that the distributed quality traceability system can track the wheat products quality information in the whole supply chain of wheat products effectively

La danza appassionata (Passion dance) : Parisian fox-tango

Gift of Dr. Mary Jane Esplen.Piano [instrumentation]B flat major [key]Allegretto Moderato [tempo]Tango. [form/genre]Portrait of Carlos Sebastian ; courtyard with building in background. [illustration]Frank K. Root and Co., Chicago. [dealer stamp]Publisher's advertisement on front inside cover and back cover. [note

The weight and the target protein of the drugs in the panel.

<p>The weight and the target protein of the drugs in the panel.</p

The amounts and the distribution of the non covalent bonds of Oseltamivir, Zanamivir and Amantadine on pocket_2hu4 and pocket_1nyj.

<p>The amounts and the distribution of the non covalent bonds of Oseltamivir, Zanamivir and Amantadine on pocket_2hu4 and pocket_1nyj.</p

The drugs docking with pocket_2hu4 and pocket_1nyj.

<p>(A). Oseltamivir docking with pocket_2hu4. (B). Zanamivir docking with pocket_2hu4. (C). Amantadine docking with pocket_2hu4. (D). Oseltamivir docking with pocket_1nyj. (E). Zanamivir docking with pocket_1nyj. (F). Amantadine docking with pocket_1nyj.</p

The pockets filled with drug&drug complex.

<p>(A).The position of pocket_1rd8 filled with Aspirin and Isosorbide.(B). The position of pocket_2hu4 filled with Aspirin, Isosorbide, Heroin, Oseltamivir and Azichromcin (C). The position of pocket_1nyj filled with Aspirin, Isosorbide, Heroin, Amantadine, Zanamivir and Oseltamivir. (D). The position of pocket_3cm8 filled with Aspirin, Isosorbide, Heroin, Amantadine, Zanamivir and Oseltamivir. (E). The position of pocket_3hw3 filled with all 9 drugs.</p

The values of MFE between 9 drugs and 5 drug binding pockets.

<p>The values of MFE between 9 drugs and 5 drug binding pockets.</p

Two examples of drug & drug complexes.

<p>(A). The amplified picture shows that pocket_2hu4 was docked by Azichromycin & Aspirin complex. (B). The amplified picture shows that pocket_2hu4 was docked by HEM & Aspirin complex. (C). The picture to show that 2D topological diagram of Azichromycin & Aspirin complex.</p