9 research outputs found
Metal-Free Oxidative Spirocyclization of Hydroxymethylacrylamide with 1,3-Dicarbonyl Compounds: A New Route to Spirooxindoles
A metal-free oxidative spirocyclization of hydroxymethylacrylamide with 1,3-dicarbonyl compounds is described. The reaction proceeds through tandem dual C–H functionalization and intramolecular dehydration, in which two new C–C bonds and one C–O bond were formed. This method affords a novel and straightforward access to various spirooxindoles under mild conditions
Palladium-Catalyzed Alkylarylation of Acrylamides with Unactivated Alkyl Halides
An efficient palladium-catalyzed
alkylarylation of acrylamides
with unactivated alkyl halides has been developed. This method is
highlighted by its broad substrate scope and excellent functional
group tolerance. In addition to alkyl halides, fluoroalkyl halides
and benzyl bromides also participated well in this transformation.
A detailed mechanistic investigation suggests that a radical pathway
is probably involved in the cyclization process
Alkynylation of Tertiary Cycloalkanols via Radical C–C Bond Cleavage: A Route to Distal Alkynylated Ketones
An
efficient Na<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-promoted
radical coupling of tertiary cycloalkanols with alkynyl hypervalent
iodide reagents via C–C bond cleavage was developed. This tandem
ring-opening/alkynylation procedure showed some advantages, including
mild conditions and wide substrate scope, thus providing a simple
synthetic method for β-, γ- and δ-alkynylated ketones
Decarboxylative Alkynylation of α‑Keto Acids and Oxamic Acids in Aqueous Media
A mild
K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> promoted decarboxylative
alkynylation of α-keto acids and oxamic acids has been developed.
This process features mild reaction conditions, a broad substrate
scope, and good functional-group tolerance, therefore providing a
new and efficient access to a wide range of ynones and propiolamides.
Furthermore, this radical process could also be successfully applied
to alkynylation of the C<sub>sp<sup>2</sup></sub>–H bond in
DMF with hypervalent alkynyl iodide reagents
Direct C–H Cyanoalkylation of Heteroaromatic <i>N</i>‑Oxides and Quinones via C–C Bond Cleavage of Cyclobutanone Oximes
A direct
C–H cyanoalkylation of heteroaromatic <i>N</i>-oxides
and quinones with cyclobutanone oximes is reported. This
redox-neutral, operationally simple cyanoalkylation reaction is successfully
amenable to a wide range of heteroaromatic <i>N</i>-oxides,
quinones, and cyclobutanone oximes. A novel catalytic system consisting
of a nickel source proved crucial for cleavage of the C–C bond
of cyclobutanone oximes and for selective C–C bond formation
over β-hydride elimination. Mechanistic studies suggest that
a radical intermediate might be involved in this transformation
Redox-Neutral Cyanoalkylation/Cyclization of Olefinic 1,3‑Dicarbonyls with Cycloketone Oxime Esters: Access to Cyanoalkylated Dihydrofurans
Metal-catalyzed cyanoalkylation/cyclization
of olefinic 1,3-dicarbonyls
with cycloketone oxime esters has been developed under redox-neutral
conditions. This protocol provided a straightforward approach to diverse
cyanoalkylated 2,3-dihydrofurans via a tandem ring-opening/addition/cyclization
process
Iron-Catalyzed Decarboxylative Olefination of Cycloketone Oxime Esters with α,β-Unsaturated Carboxylic Acids via C–C Bond Cleavage
An
iron-catalyzed redox-neutral, decarboxylative olefination of
cycloketone oxime esters with α,β-unsaturated carboxylic
acids has been developed. This reaction involves an iminyl radical
mediated C–C bond cleavage/radical addition/decarboxylation
cascade. This protocol is highlighted by its low-cost catalytic system
and readily accessible starting materials, as well as broad substrate
scope, thus providing facile access to structurally diverse cyano-containing
alkenes
Metal-Free, Visible-Light-Promoted Decarboxylative Radical Cyclization of Vinyl Azides with <i>N</i>‑Acyloxyphthalimides
A visible-light-mediated decarboxylative
cyclization of <i>N</i>-acyloxylphthalimides with vinyl
azides has been developed
under metal-free conditions. This protocol features mild conditions,
a broad substrate scope, and an excellent functional group tolerance,
thus providing a facile and efficient access to substituted phenanthridines.
Control experiments revealed that the reaction proceeded via a radical
process
Nickel-Catalyzed Modular Four-Component 1,4-Alkylcarbonylation of 1,3-Enynes to Tetra-Substituted CF<sub>3</sub>–Allenyl Ketones
The
modular four-component carbonylation of unsaturated hydrocarbons
represents an elegant strategy for the one-pot synthesis of complex
carbonyl compounds. However, this strategy is currently focused on
the 1,2-difunctionalization of olefins or alkynes, and the 1,4-alkylcarbonylation
of 1,3-enynes remains unexplored. In this study, we report a Ni-catalyzed
1,4-alkylcarbonylation of CF3-containing 1,3-enynes under
1 atm of CO, which affords the tetra-substituted CF3-allenyl
ketones with good yields and selectivity. This protocol features mild
conditions, broad substrate scope, and acceptable functional group
compatibility. Control experiments revealed that the reactivity of
oxime esters (regulated by leaving groups) and polarity matching are
crucial for the success of this four-component cascade. Preliminary
mechanistic studies suggest that the acyl nickel complex is a key
intermediate in this transformation