Reminder duration determines threat memory modification in humans

Memory reminders can return a memory into an unstable state such that it will decay unless actively restabilized into long-term memory through reconsolidation. Exposure to a memory reminder, however, does not always lead to destabilization. The 'trace dominance' principle posits that the extent of exposure to memory reminders governs memory susceptibility to disruption. Here, we provide a first systematic investigation of reminder duration effects on threat memory modification in humans. Reminder duration was parametrically varied across 155 participants in a three-day protocol. We found that short reminders (1 s and 4 s) made the memory prone to interference from post-retrieval extinction, suggesting that the memory had been updated. In contrast, no reminder or long reminders (30 s and 3 min) made the memory resistant to such interference, and robustly return. Reminder duration therefore influences memory stability and may be a critical determinant of therapeutic efficacy

Neuroticism and fear of COVID-19 during the COVID-19 pandemic: Testing the mediating role of intolerance of uncertainty and sense of control among Chinese high school students

Since the COVID-19 pandemic broke out in 2019, neuroticism has been proven a predictor of fear of COVID-19 infection. However, only few studies have been conducted on the factors affecting the relationship between neuroticism and this kind of fear. The present study is aimed at analyzing the role intolerance of uncertainty (IU) and sense of control (SOC) play in relation to neuroticism and the fear of COVID-19. We conducted a cross-sectional study in Guangdong and Guangxi provinces, China, and we collected complete datasets from 792 high school students. The main results can be described as follows: (a) individuals with high neuroticism tended to have higher intolerance of uncertainty (IU) and a lower sense of control (SOC); (b) IU and SOC played a mediating role between neuroticism and fear of COVID-19, and a serial mediation effect was found between these factors; (c) after controlling for both IU and SOC, the effect of neuroticism on fear was no longer significant. The results suggested a critical role of IU and sense of control in the causal relationship between neuroticism and fear

Author Correction: Reminder duration determines threat memory modification in humans

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Gender Differences in PTSD: Susceptibility and Resilience

Posttraumatic stress disorder (PTSD) is anxiety disorder that has been estimated to affect individuals who are exposed to traumatic events. Women are diagnosed with PTSD approximately twice as often as men. In this review, we outline the evidence of gender differences related to PTSD, and the factors of resilience and susceptibility differ between men and women

State Anxiety Down-Regulates Empathic Responses: Electrophysiological Evidence

State anxiety is common in our life and has a significant impact on our emotion, cognition and behavior. Previous studies demonstrate that people in a negative mood are associated with low sympathy and high personal distress. However, it is unknown how state anxiety regulates empathic responses so far. Here, we recorded event-related brain potentials (ERP) from the experimental group who were in state anxiety and the control group when they were watching painful and neutral pictures. Participants in the experimental group and the control group were asked to do the same mental arithmetic problems. The only difference was that the experimental group had time restriction and was evaluated by the observer. The results showed that no significant N2 differentiation between painful and neutral stimuli was found in both groups. In contrast, LPP amplitudes induced by painful stimuli were significantly larger than that of neutral stimuli in the control group, but not in the experimental group. Our results indicate that state anxiety inhibit empathic responses from the early emotional sharing stage to the late cognitive evaluation stage. It provides neuroscientific evidence that one’s own emotional state will have an important impact on empathy

Competitive Intensity Modulates the Pain Empathy Response: An Event-Related Potentials Study

Previous studies have widely reported that competition modulates an individual’s ability to empathize with pain experienced by others. What remains to be clarified, however, is how modulations in the intensity of competition might affect this type of empathy. To investigate this, we first used a Eriksen Flanker task to set different competitive intensity context (high competitive intensity, HCI; medium competitive intensity, MCI; low competitive intensity, LCI). Then we used a recognition task as a competitive task, in which we recorded event-related potentials (ERP) while participants viewed static images of body parts in painful and non-painful situations. Participants were informed that both sets of images depicted an opponent that they were required to play against in the recognition task that varied in levels of competitive intensity according to condition (HCI, MCI, and LCI). We observed an early N2 differentiation between pain and no-pain stimuli over the frontal area under MCI and LCI conditions, but this was not detected under HCI condition. Moreover, we observed a pattern of pain and no-pain differentiation for the late LPP over the frontal and centro-parietal regions under HCI, MCI, and LCI condition. As the pain empathy response is indexed by pain and no-pain differentiation, these results indicate a down-regulation of pain empathy response attributable to a high level of competition. With its very early onset, this effect appears to inhibit bottom-up processing of the ability to perceive pain experienced by an opponent. Our results provide neuroscientific evidence for a deficit in early automatic arousal in response to the pain of the opponent under the influence of high competitive intensity

Self-Interest Induces Counter- Empathy at the Late Stage of Empathic Responses to Others’ Economic Payoffs

Previous studies have found that individuals exhibit empathic responses when others are treated unfairly. However, there remains a lack of clarity over the extent to which self-interest regulates these empathic responses, and in identifying which component of empathy is more likely to be affected. To investigate these issues, an experiment was designed based on a money distribution task with two conditions [observation condition (OC) vs. participation condition (PC)], and carried out using scalp-recorded event-related potentials (ERPs). Behavioral data showed that the participants’ empathic responses were consistent with their coplayers’ emotional expressions in the OC, whereas they were inconsistent with the coplayers’ expressions in the PC. The electrophysiological data showed that the neural encoding of facial expressions (reflected in the N170) was not affected by self-interest. However, the late stage of empathic responses (LPP) showed a decline when participants’ self-interest was involved. Disadvantageous inequality and relatively fair distribution to others elicited a more pronounced feedback-related negativity (FRN) than advantageous inequality distribution in both the OC and PC. As the late stage of empathic responses is also indexed by the LPP amplitude, these results indicate that the participants were more concerned for their own outcomes than for others’ benefits when self-interest was involved, which reduced their empathy toward their coplayers at the late stage of empathic responses

The Topological Properties of Stimuli Influence Fear Generalization and Extinction in Humans

Fear generalization is an etiologically significant indicator of anxiety disorders, and understanding how to inhibit it is important in their treatment. Prior studies have found that reducing fear generalization using a generalization stimulus (GS) is ineffective in removing a conditioned fear that incorporates local features, and that topological properties appear to play a comparatively more significant role in the processes of perception and categorization. Our study utilized a conditioned-fear generalization design to examine whether the topological properties of stimuli influence the generalization and return of fear. Fear was indexed using online expectancy ratings and skin conductance responses (SCRs). The study’s 52 participants were divided into three groups: Group 1, conditioned danger cue (CS+) extinction; Group 2, extinction of one GS; Group 3, extinction of three GSs. We found that the three groups acquired conditioned fear at the same level. In the generalization and extinction phase, fear was transferred to the GS with the same topological properties as CS+, and gradual decreases in both shock expectancy and SCRs over non-reinforced extinction trials were observed. In the test phase, participants’ online expectancy ratings indicated that fear did not return in Group 1, but did return in Groups 2 and 3. All three groups demonstrated successful GS fear extinction, but only Group 1 did not show a return of fear for CS+. Regarding SCRs results, none of the groups demonstrated a return of fear, suggesting that utilization of topological properties successfully reduced the return of conditioned fear. Our results indicate that, in clinical settings, using GS with topological equivalence to CS+ might offer a potential method with which to extinct conditioned fear

The influence of word concreteness on acquired positive emotion association: An event-related potential study

The ability to acquire positive emotions from words is essential to psychological well-being. How word concreteness affects the process of positive emotion acquisition remains unknown. Here, using an evaluation conditioning paradigm, participants learned the association between pseudowords and concrete/abstract and positive/neutral words. Behavior and event-related potential data were recorded while participants performed emotional recognition tasks. Behavioral results showed that, for neutral words, concrete words were more accurate than abstract words, whereas for positive words, abstract words were more accurate than concrete words. Moreover, N1 and P2 amplitudes in the pseudowords were modulated by interacting word emotion and concreteness. Specifically, pseudowords associated with neutral concrete words elicited larger N1 and P2 amplitudes than pseudowords associated with neutral abstract words. Conversely, N1 and P2 amplitudes in pseudowords associated with positive abstract words were not significant compared to those in positive concrete words. Additionally, an emotional effect was observed when pseudowords were associated with abstract words, showing higher P3 amplitude for the pseudowords associated with positive abstract words than neutral abstract words. No significant effects were found for the pseudowords associated with positive abstract or concrete words. These findings suggest that association learning may influence the early attention processing of emotion acquisition from words, and emotional information of positive abstract words might boost positive emotion acquisition, thereby eliminating the acquisition advantage from positive concrete words

Comparison of dynamic contrast-enhanced magnetic resonance imaging with T2-weighted imaging for preoperative staging of early endometrial carcinoma.

PurposeThis study aimed to compare dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with T2-weighted imaging (T2WI) for the preoperative staging of early endometrial carcinoma.MethodsThis retrospective study included 22 subjects with early endometrial carcinoma who underwent 3.0 T MRI examination prior to hysterectomy. DCE-MRI and T2WI were evaluated for the preoperative staging of endometrial carcinoma. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of DCE-MRI and T2WI were assessed and compared using the revised International Federation of Gynecology and Obstetrics surgical staging guidelines (2009) as the reference standard.ResultsOut of the 22 cases of endometrial carcinoma, the use of the reference standard method led to the staging of 14 as IA and eight as IB. The sensitivity, specificity, PPV, NPV, and accuracy of DCE-MRI for preoperative staging were 100% (95% confidence interval: 0.73-1.0), 62.5% (95% CI: 0.26-0.90), 82.4% (95% CI: 0.56-0.95), 100% (95% CI: 0.46-1.0), and 86.4%, respectively, and these values were 85.7% (95% CI: 0.56-0.97), 75% (95% CI: 0.36-0.96), 85.7% (95% CI: 0.56-0.97), 75% (95% CI: 0.36-0.96), and 81.8%, respectively, for T2WI. Thus, the sensitivity and accuracy of DCE-MRI were greater than those of T2WI for preoperative endometrial carcinoma staging.ConclusionDCE-MRI was more sensitive but less specific than T2WI for the preoperative staging of early endometrial carcinoma. DCE-MRI may serve as a useful and reliable tool for the preoperative assessment of endometrial carcinoma