Global Detection of Live Virtual Machine Migration Based on Cellular Neural Networks

In order to meet the demands of operation monitoring of large scale, autoscaling, and heterogeneous virtual resources in the existing cloud computing, a new method of live virtual machine (VM) migration detection algorithm based on the cellular neural networks (CNNs), is presented. Through analyzing the detection process, the parameter relationship of CNN is mapped as an optimization problem, in which improved particle swarm optimization algorithm based on bubble sort is used to solve the problem. Experimental results demonstrate that the proposed method can display the VM migration processing intuitively. Compared with the best fit heuristic algorithm, this approach reduces the processing time, and emerging evidence has indicated that this new approach is affordable to parallelism and analog very large scale integration (VLSI) implementation allowing the VM migration detection to be performed better

Modulation of Bax and mTOR for Cancer Therapeutics.

A rationale exists for pharmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer strategy. Here, we report the refinement of the Bax agonist SMBA1 to generate CYD-2-11, which has characteristics of a suitable clinical lead compound. CYD-2-11 targeted the structural pocket proximal to S184 in the C-terminal region of Bax, directly activating its proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes. In murine models of small-cell and non-small cell lung cancers, including patient-derived xenograft and the genetically engineered mutant KRAS-driven lung cancer models, CYD-2-11 suppressed malignant growth without evident significant toxicity to normal tissues. In lung cancer patients treated with mTOR inhibitor RAD001, we observed enhanced S184 Bax phosphorylation in lung cancer cells and tissues that inactivates the propaoptotic function of Bax, contributing to rapalog resistance. Combined treatment of CYD-2-11 and RAD001 in murine lung cancer models displayed strong synergistic activity and overcame rapalog resistanc

Influence of Variable Rigidity Design of Piled Raft Foundation on Seismic Performance of Buildings

In order to reduce the costs and improve the overall performance of building systems, the static optimized design with variable rigidity of piled raft foundations has been widely used in recent years. Variable rigidity design of piled raft foundations that support midrise buildings in high-risk seismic zones can alter the dynamic characteristics of the soil-pile-structure system during an earthquake due to soil-pile-structure interaction. To investigate these aspects, a nuclear power plant sitting on multilayered soil is simulated numerically. The paper describes a numerical modeling technique for the simulation of complex seismic soil-pile-structure interaction phenomena. It was observed that the total shear force on top of the piles and the rocking of the raft are reduced after optimization, whereas the displacement of the superstructure is nearly unaffected. The findings of this study can help engineers select a correct pile arrangement when considering the seismic performance of a building sitting on soft soil

Experimental study on ASR performance of concrete with nano-particles

Alkali-silica reaction (ASR) is a serious durability problem, resulting in significant maintenance and reconstruction cost of concrete infrastructure all over the world, so more and more attention has been attracted to it. This paper tends to discuss whether nano-SiO2 and nano-Fe2O3 can mitigate the concrete deterioration caused by ASR. The test results show that the concretes with nano-particles have lower expansion and higher sonic velocity. Therefore, it is an available method for concrete to mix with nano-particles to mitigate ASR and the optimum content of nano-SiO2 and nano-Fe2O3 in concrete is 2.0% and 1.0%, respectively. The mitigating mechanism is revealed through the effect of mixing water on the porosity

Progress of the technique of coal microwave desulfurization

Abstract With the advantages of its fast speed, effective and moderate controllable conditions, desulfurization of coal by microwave has become research focus in the field of clean coal technology. Coal is a homogeneous mixture which consists of various components with different dielectric properties, so their abilities to absorb microwaves are different, and the sulfur-containing components are better absorbers of microwave, which makes them can be selectively heated and reacted under microwave irradiation. There still remain controversies on the principle of microwave desulfurization at present, thermal effects or non-thermal effects. The point of thermal effects of microwave is mainly base on its characters of rapidly and selectly heating. While, in view of non-thermal effect, direct interactions between the microwave electromagnetic field and sulfur containing components are proposed. It is a fundamental problem to determine the dielectric properties of coal and the sulfur-containing components to reveal the interaction of microwave and sulfur-containing compounds. However, the test of dielectric property of coal is affected by many factors, which makes it difficult to measure dielectric properties accurately. In order to achieve better desulfurization effect, the researchers employ methods of adding chemical additives such as acid, alkali, oxidant, reductant, or changing the reaction atmosphere, or combining with other methods such as magnetic separation, ultrasonic and microorganism. Researchers in this field have also put forward several processes, and have obtained a number of patents. Obscurity of microwave desulfurization mechanism, uncertainties in qualitative and quantitative analysis of sulfur-containing functional groups in coal, and the lack of special microwave equipment have limited further development of microwave desulfurization technology

Additional file 1: of Bcl2 inhibition of mitochondrial DNA repair

Supplemental data. Supplemental Figures (Figures S1-S4.) are included. (PDF 403 kb