TSUP Speaker Diarization System for Conversational Short-phrase Speaker Diarization Challenge

This paper describes the TSUP team's submission to the ISCSLP 2022 conversational short-phrase speaker diarization (CSSD) challenge which particularly focuses on short-phrase conversations with a new evaluation metric called conversational diarization error rate (CDER). In this challenge, we explore three kinds of typical speaker diarization systems, which are spectral clustering(SC) based diarization, target-speaker voice activity detection(TS-VAD) and end-to-end neural diarization(EEND) respectively. Our major findings are summarized as follows. First, the SC approach is more favored over the other two approaches under the new CDER metric. Second, tuning on hyperparameters is essential to CDER for all three types of speaker diarization systems. Specifically, CDER becomes smaller when the length of sub-segments setting longer. Finally, multi-system fusion through DOVER-LAP will worsen the CDER metric on the challenge data. Our submitted SC system eventually ranks the third place in the challenge

Population dynamical behavior of Lotka-Volterra system under regime switching

In this paper, we investigate a Lotka-Volterra system under regime switching dx(t) = diag(x1(t); : : : ; xn(t))[(b(r(t)) + A(r(t))x(t))dt + (r(t))dB(t)]; where B(t) is a standard Brownian motion. The aim here is to find out what happens under regime switching. We first obtain the sufficient conditions for the existence of global positive solutions, stochastic permanence and extinction. We find out that both stochastic permanence and extinction have close relationships with the stationary probability distribution of the Markov chain. The limit of the average in time of the sample path of the solution is then estimated by two constants related to the stationary distribution and the coefficients. Finally, the main results are illustrated by several examples

Insights into the genetic influences of the microbiota on the life span of a host

Escherichia coli (E. coli) mutant strains have been reported to extend the life span of Caenorhabditis elegans (C. elegans). However, the specific mechanisms through which the genes and pathways affect aging are not yet clear. In this study, we fed Drosophila melanogaster (fruit fly) various E. coli single-gene knockout strains to screen mutant strains with an extended lifespan. The results showed that D. melanogaster fed with E. coli purE had the longest mean lifespan, which was verified by C. elegans. We conducted RNA-sequencing and analysis of C. elegans fed with E. coli purE (a single-gene knockout mutant) to further explore the underlying molecular mechanism. We used differential gene expression (DGE) analysis, enrichment analysis, and gene set enrichment analysis (GSEA) to screen vital genes and modules with significant changes in overall expression. Our results suggest that E. coli mutant strains may affect the host lifespan by regulating the protein synthesis rate (cfz-2) and ATP level (catp-4). To conclude, our study could provide new insights into the genetic influences of the microbiota on the life span of a host and a basis for developing anti-aging probiotics and drugs

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation

The Influence of Working Memory Load of Binding on Selective Attention

PURPOSE: Ample studies have documented that working memory (WM) load has a comprehensive influence on selective attention in perception. Moreover, the influence of WM on selective attention is modulated by the type of WM subsystem, by revealing opposite modulation by central executive and visual WM. However,&nbsp; no study so far has examined the influence of WM load of binding on selective attention. Moreover, there are two opposite views as to this issue: On the one hand, an independent episodic buffer is suggested to be in charge of binding with the attention from of central executive, suggesting that binding load will functions as a type of central executive; on the other hand, recent studies revealed that object-based attention plays a key role in both visual WM and binding representation in WM, implying that binding load will serve as a type of visual WM load. To this end, we examined the influence of WM load of binding on selective attention by requiring the participants to memorize two or five bindings in WM. METHODS: Critically, a low load perceptual task was interpolated in the maintenance phase of WM. The low load perceptual task contained either a low-priority target or was an response competition task. RESULTS: In three experiments, we found that high WM load of binding led to reduced detection of low-priority target (Experiments 1-2), and less interference from the distractor in the response competition task (Experiment 3). CONCLUSION: These results suggest that WM load of binding is similar to visual WM load, serving as a type of perceptual load and hence competing resources with the perceptual task.&nbsp;</p

System Performance and Empathetic Design Enhance User Experience for Fault Diagnosis Expert System

The fault diagnosis task in factories is technically demanding and time-consuming, especially for the green hands. In order to assist mechanicians to detect the fault parts, the fault diagnosis expert system is introduced to support decision-making and problem-solving processes. In this vision, how to enhance mechanicians&rsquo; willingness to use such a system becomes a key issue to the industry. The present study aims to find out the elements that affect the user experience of the fault diagnosis expert system. We carried out an experiment to investigate how system performance and empathetic design promotes user experience, and we also explored how those factors apply to different users with high and low expertise. Fourteen participants who majored in automatic control with a basic understanding of industrial automation devices took part in the study. During the experiment, the participants were instructed to repair a UV control cabinet with the help of the fault diagnosis expert system. The system has four levels of system performance (high, medium, low, and all-errors) * two levels of empathetic feature (standard design vs. empathetic design). After each task, the participants filled out a questionnaire to evaluate their experience. The results showed a beneficial effect of both system performance and empathetic design. Also, the interactive effect indicates that for the system with qualified performance, the empathetic design enhanced user experience; while for the system with all-error performance, the empathetic design no longer helped. In addition, the empathetic design played a better role among inexperienced users, while experienced users tended to be more sensitive to changes in system performance. &nbsp;</p

The Cueing Effect in Retrieval of Expertise: Designing for Future Intelligent Knowledge Management System.

Along with the rapid technological developments in the past few decades, human work is becoming more knowledge-based, and professional expertise is becoming even more important. In this way, effective methods to retrieve and transfer such expertise are greatly needed. Prior research has found that pictures can be used as visual cues for supporting general memory retrieval, but whether this effect can be used to support professional expertise retrieval is not fully understood. The aim of the present study is to explore whether the picture cues can support the retrieval of professional expertise in a typical mechanical fault diagnosis task. Sixteen postgraduates who majored in mechanics with vehicle repair experience took part in the study. On the first day, they were trained for 1.5&nbsp;h on a simulated vehicle maintenance and repair task. After that, they were asked to accomplish three fault diagnosis tasks. On the next day, they participated in a 30-min expertise retrieval test. In the test, they were presented with or without picture cues (i.e., key-picture-cue, random-picture-cue, and without cues) and then answered questions to measure their memory over yesterday&rsquo;s operations. The results showed that participants retrieved more accurately with picture-cues compared to the scenario without the cues, and the accuracy in the key-picture-cues scenario was higher than the random-picture-cues scenario. These results show a robust cueing effect in the retrieval of expertise in fault diagnosis operations and indicated a potential application of expertise retrieval and transfer when designing an intelligent knowledge management system in the future.</p

Carbon nanotubes/carbon paper composite electrode for sensitive detection of catechol in the presence of hydroquinone

The fabrication and application of carbon nanotubes/carbon paper (CNTs/CP) composite electrochemical sensors are reported. This sensing platform allows the sensitive determination of catechol in the range of 1 μM to 100 μM with a detection limit of 0.29 μM. The catechol detection in tea samples demonstrates the applicability of this method. The present study explores an interesting and significant application of CNTs/CP composite in electroanalysis. Keywords: Carbon nanotubes/carbon paper, Electrochemical sensor, Catechol, Tea sample